Job title: Profssor of Neuroscience
Phone: 027 8369 2630
Academic Areas: Neuroscience
Research Interests: sensory processing, structure and function of neuronal circruit
Our lab is interestred in understanding the relationship between the structure and function of neuronal network. By combining the state-of-art brain mapping technique and in vivo electrophysiology and functional imaging, it enables us to correlate the functional and structural properties of individual neurons. Using mouse visual cortex as model, we are trying to study how the refined network structure meets the enormous computational capability demanded by sensory processing. We hope that our work will shed some light on the general rules of brain network organization.
PhD in Neuroceince, 2011, École Polytechnique Fédérale de Lausanne (EPFL, Lausanne, Switzerland)
MS in Neuroceince, 2006, Max-Plank International Research School / George-August-Universität Göttingen (Göttinggen, Germany）
BS in Biological Science, 2003, Tsinghua University (Beijing, China)
Professor (2015-present), Huazhong University of Science and Technology, School of Basic Medicine, Department of Neurobiology
Postdoc (2012-2015), University College London (London, UK) and University of Basel (Basel, Switzerland)
Yan, H., Pang, P., Chen, W., Zhu, H., Henok, K. A., Li, H., Wu, Z., Ke, X., Wu, J., Zhang, H., Pan, K., Pei, L., Han, Y.#, Lu, Y.# (2017). The Lesion Analysis of Cholinergic Neurons in 5XFAD Mouse Model in the Three-Dimensional Level of Whole Brain. Mol. Neurobiol. 1–11. Available at: http://dx.doi.org/10.1007/s12035-017-0621-4. (# co-corresponding author)
Pecka, M.*, Han, Y.*, Sader, E.*, & Mrsic-Flogel, T. D. (2014). Experience-dependent specialization of receptive field surround for selective coding of natural scenes. Neuron 84, 457–469. (*co-first author)
Han Y, Babai N, Kaeser P, Sudhof T, Schneggenburger R. (2015) . RIM1 and RIM2 redundantly determine Ca2+ channel density and readily-releasable pool size at a large hindbrain synapse. J Neurophysiol, 113, 255-63.
Han, Y., & Mrsic-Flogel, T. (2013). A finely tuned cortical amplifier. Nature Neuroscience 16, 1166–1168.
Han, Y, Kaeser, P.S, Südhof, TC & Schneggenburger, R. (2011). RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone, Neuron 69, 304-316.
Schneggenburger, R., Han, Y., & Kochubey, O. (2012). Ca2+ channels and transmitter release at the active zone. Cell Calcium, 3-4, 199-207.
Xiao, L., Han, Y., Runne, H., Murray, H., Kochubey, O., Luthi-Carter, R., & Schneggenburger, R. (2010). Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons. Molecular and Cellular Neurosciences 44, 374-385.
Kochubey, O., Han, Y., & Schneggenburger, R. (2009). Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held. Journal of Physiology 587, 3009-3023.
Han, Y.*, Kebschull, J. M.*, Campbell, R. A. A., Cowan, D., & Imhof, F., Zador, A. M.#, & Mrsic-Flogel, T. D#. (in preparation). A single-cell anatomical blueprint for intracortical information transfer from primary visual cortex. (*co-first author, # co-corresponding author)
2015, Junior Program of 1000 Talent Recruitment Project