Job title: Associate Professor

Phone: 86(27)18627992951

Email: leijiahui@hust.edu.cn

Academic Areas: Parasitology

Research Interests: Parasite immunology

Academic Degrees

PhD in Pathogen Biology, 2009, Huazhong University of Science and Technology Wuhan, China

BS in Clinic Medicine, 1999, Tongji Medical University

Professional Experience

Associate Professor (2010-present ), Huazhong University of Science and Technology, Department of Parasitology;

Lecturer (2004-2010), Huazhong University of Science and Technology, Department of Parasitology 

Selected Publications

 

  1. Yu Y, Deng W, Lei JH*.Interleukin-33 promotes Th2 immune responses in infected mice with Schistosoma japonicum.Parasitol Res. 2015;114(8):2911-8. (*corresponding author)
  2. Nie G, Wang T, Lu S, Liu W, Li Y,Lei JH*.Detection of Clonorchis sinensis circulating antigen in sera from Chinese patients by immunomagnetic bead ELISA based on IgY. PLoS One. 2014;(12):113208. (*corresponding author)
  3. Tang CL, Lei JH, Guan F, Li YL, Liu R, Grevelding CG, Jiang MS, Dong HF. Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine schistosomiasis japonica.Exp Parasitol. 2014;136:74-8.
  4. Chen QR, Guan F, Song SM, Jin JK, Lei DS, Chen CM, Lei JH, Chen ZW, Niu AO.Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum.Parasitol Res. 2014;113(7):2629-39.
  5. Zhao FJ, Huang XY, Hou X, Deng Y, Wu MY, Guan F, Liu WQ, Li YL, Lei JH*.Schistosoma japonicum: susceptibility of neonate mice born to infected and non-infected mothers following subsequent challenge.Parasite Immunol. 2013; 1: 157–163. (*corresponding author)
  6. Guan F, Hou X, Nie G, Xiao Y, Zhang Q, Liu WQ, Li YL, Lei JH*.Effect of Trichinella spiralis infection on the immune response to HBV vaccine in a mouse model.Foodborne Pathog Dis. 2013;10(10):882-7. (*corresponding author)
  7. Lei JH, Guan F, Xu H, Chen L, Su BT, Zhou Y, Wang T, Li YL, Liu WQ. Application of an immunomagnetic bead ELISA based on IgY for detection of circulating antigen in urine of mice infected with Schistosoma japonicum.Vet Parasitol. 2012;187(1-2):196-202.
  8. Chen L, Liu WQ, Lei JH, Guan F, Li MJ, Song WJ, Li YL, Wang T.Chronic Schistosoma japonicum infection reduces immune response to vaccine against hepatitis B in mice.PLoS One. 2012;7(12):e51512.
  9. Wang T, Fang ZM, Lei JH, Guan F, Liu WQ, Bartlett A, Whitfield P, Li YL. Delayed tail loss during the invasion of mouse skin by cercariae of Schistosoma japonicum. Parasitology. 2012;139(2):244-7.
  10. Lei JH, Su BT, Xu H, Shen LH, Guan XH, Feng ZQ, Li YL, Xu MX, Liu WQ.Evaluation of an IgY-based Immunomagnetic ELISA System for Detection of Circulating Schistosoma japonicum Antigen in Sera of Chinese Patients.Am J of Trop Med and Hyg. 2011; 85(6):1054-9.
  11. Tang CL, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL.Effect of CD4+ D25+ regulatory T cells on the immune evasion of Schistosoma japonicum. Parasitol Res. 2011; 108(2): 477-80.
  12. Li MJ, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol. 2011; 128(4):427-32.
  13. Cheng YL, Song WJ, Liu WQ, Lei JH, Kong Z, Li YL.The effects of interleukin (IL)-12 and IL-4 deficiency on worm development and granuloma formation in Schistosoma japonicum-infected mice.Parasitol Res. 2012;110(1):287-93.
  14. Lei JH, Liu WQ, Sun CS, Tang CL, Li MJ, Chen YL, Li YL. Detection of circulating antigen in serum of mice infected with Schistosoma japonicum by immunomagnetic bead ELISA based on IgY. Acta Trop. 2009; 111(1): 39-43.
  15. Yu Y, Deng W, Lei JH*.Interleukin-33 promotes Th2 immune responses in infected mice with Schistosoma japonicum.Parasitol Res. 2015;114(8):2911-8. (*corresponding author)
  16. Nie G, Wang T, Lu S, Liu W, Li Y,Lei JH*.Detection of Clonorchis sinensis circulating antigen in sera from Chinese patients by immunomagnetic bead ELISA based on IgY. PLoS One. 2014;(12):113208. (*corresponding author)
  17. Tang CL, Lei JH, Guan F, Li YL, Liu R, Grevelding CG, Jiang MS, Dong HF. Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine schistosomiasis japonica.Exp Parasitol. 2014;136:74-8.
  18. Chen QR, Guan F, Song SM, Jin JK, Lei DS, Chen CM, Lei JH, Chen ZW, Niu AO.Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum.Parasitol Res. 2014;113(7):2629-39.
  19. Zhao FJ, Huang XY, Hou X, Deng Y, Wu MY, Guan F, Liu WQ, Li YL, Lei JH*.Schistosoma japonicum: susceptibility of neonate mice born to infected and non-infected mothers following subsequent challenge.Parasite Immunol. 2013; 1: 157–163. (*corresponding author)
  20. Guan F, Hou X, Nie G, Xiao Y, Zhang Q, Liu WQ, Li YL, Lei JH*.Effect of Trichinella spiralis infection on the immune response to HBV vaccine in a mouse model.Foodborne Pathog Dis. 2013;10(10):882-7. (*corresponding author)
  21. Lei JH, Guan F, Xu H, Chen L, Su BT, Zhou Y, Wang T, Li YL, Liu WQ. Application of an immunomagnetic bead ELISA based on IgY for detection of circulating antigen in urine of mice infected with Schistosoma japonicum.Vet Parasitol. 2012;187(1-2):196-202.
  22. Chen L, Liu WQ, Lei JH, Guan F, Li MJ, Song WJ, Li YL, Wang T.Chronic Schistosoma japonicum infection reduces immune response to vaccine against hepatitis B in mice.PLoS One. 2012;7(12):e51512.
  23. Wang T, Fang ZM, Lei JH, Guan F, Liu WQ, Bartlett A, Whitfield P, Li YL. Delayed tail loss during the invasion of mouse skin by cercariae of Schistosoma japonicum. Parasitology. 2012;139(2):244-7.
  24. Lei JH, Su BT, Xu H, Shen LH, Guan XH, Feng ZQ, Li YL, Xu MX, Liu WQ.Evaluation of an IgY-based Immunomagnetic ELISA System for Detection of Circulating Schistosoma japonicum Antigen in Sera of Chinese Patients.Am J of Trop Med and Hyg. 2011; 85(6):1054-9.
  25. Tang CL, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL.Effect of CD4+ D25+ regulatory T cells on the immune evasion of Schistosoma japonicum. Parasitol Res. 2011; 108(2): 477-80.
  26. Li MJ, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol. 2011; 128(4):427-32.
  27. Cheng YL, Song WJ, Liu WQ, Lei JH, Kong Z, Li YL.The effects of interleukin (IL)-12 and IL-4 deficiency on worm development and granuloma formation in Schistosoma japonicum-infected mice.Parasitol Res. 2012;110(1):287-93.
  28. Lei JH, Liu WQ, Sun CS, Tang CL, Li MJ, Chen YL, Li YL. Detection of circulating antigen in serum of mice infected with Schistosoma japonicum by immunomagnetic bead ELISA based on IgY. Acta Trop. 2009; 111(1): 39-43.

 

Courses Taught

1001021 HumanParasitology (undergraduate)

510.802 Immunology of Pathogen Infections (graduate)

510.539 Immunology of Parasite Infections (graduate)

Project

 

  1. Preliminary study on role of serum exosome in the diagnosis of schistosomiasis. Program Foundation of health and family planning commission of Hubei Province, 2017-2019.
  2. Effect of IL-33/ST2 axis on Th2 immune response in schistosomiasis japonica. Creative Foundation of Huazhong University of Science and Technology, 2016-2017.
  3. Protection and its mechanism of cardiac allografts caused by SAG1 and Hsp70 of Toxoplasma g-ndii. National Natural Foundation of China. The National Natural Science Foundation of China, 2011-2013.
  4. Detection of Clonorchis sinensis circulating antigen in sera from Chinese patients by immunomagnetic bead ELISA based on IgY. National Basic Research “973” Program of China, 2010-2014.
  5. Detection of circulating antigen of Schistosoma japonicum by indirect agglutination test based on IgY. Foundation of health and family planning commission of Hubei Province, 2012-2014.

 

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