Job title: Professor

Phone: 86(27)17720510069

Email: chenxq@mails.tjmu.edu.cn

Academic Areas: Pathoiphysiology of neurological diseases and cancers

Research Interests: Cellular and molecular mechanisms of stroke, autism and glioma

Academic Degrees

PhD in Biology, 2002, The Hong Kong University of Science and Technology, Hong Kong, China

MS in Medicine, 1997, Peking Union Medical College, Beijing, China

BS in Medicine, 1988, Fudan University, Shanghai, China

Professional Experience

Professor (2007-present), Huazhong University of Science and Technology, School of Basic Medicine, Department of Pathophysiology;

Associate Professor (2002-2007), Huazhong University of Science and Technology, Department of Basic Medicine School of Basic Medicine, Department of Pathophysiology;

Engineer (1997-1999), Chinese Academy of Sciences, Institute of Microbiology, Laboratory of Molecular Virology, Beijing, China;

Surgeon (1988-1994), Chinese Academy of Traditional Chinese Medicine, Xi-Yuan Hospital, Beijing, China

Selected Publications

  1. Xie XQ, Zhang P, Tian B*, Chen XQ* (corresponding author). Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke. Mol Neurobiol 2016 Oct 29. DOI:10.1007/s12035-016-0173-z. [Epub ahead of print] PMID:27796760
  2. Chen Y,Liu JM, Xiong XX, Qiu XY, Pan F, Liu D, Lan SJ, Jin S, Yu SB, Chen XQ*. Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP. Oncotarget. 2015 Mar 20; 6(8):6406-21. PMID:25788268
  3. Xiong XX, Liu JM, Qiu XY, Pan F, Yu SB, Chen XQ*. Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways. Acta Pharmacol Sin. 2015 Mar; 36(3):362-74
  4. Liu QR, Liu JM, Chen Y, Xie XQ, Xiong XX, Qiu XY, Pan F, Liu D, Yu SB, Chen XQ*. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxid Med Cell Longev. 2014;2014:653732. doi: 10.1155/2014/653732
  5. Qiu XY and Chen XQ*. Neuroglobin: Recent Developments. Biomol Concepts 5(3): 195–208, 2014
  6. XJ Lai, SQ Ye, L Zheng, L Li, QR Liu, SB Yu, Y Pang, S Jin, Q Li, ACH Yu, Chen XQ. Selective 14-­3-­3γ induction quenches p-β-­catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia. Cell Death Dis. 2014 Apr 17;5:e1184. doi: 10.1038/cddis.2014.152
  7. Li L, Liu QR, Xiong XX, Liu JM, Lai XJ, Cheng C, Pan F, Yu SB, Yu AC, Chen XQ*. Neuroglobin Promotes Neurite Outgrowth via Differential Binding to PTEN and Akt. Mol Neurobiol 49(1):149-62, 2014.
  8. Liu JM, Pan F, Li L, Liu QR, Chen Y, Xiong XX, Cheng K, Yu SB, Shi Z, Yu AC, Chen XQ*. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun 437(1): 87-93, 2013
  9. Zhang J, Lan SJ, Liu QR, Liu JM, Chen XQ*. Neuroglobin, a Novel Intracellular Hexa-coordinated Globin, Functions as a Tumor Suppressor in Hepatocellular Carcinoma Via Raf/MAPK/Erk. Mol Pharmacol 83(3): 1-11, 2013
  10. Ye SQ, Zhou XY, Lai XJ, Zheng L, Chen XQ*. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin 30(7):913-8, 2009
  11. Li D, Chen XQ*, Li WJ, Yang YH, Wang JZ, Yu AC. Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress. Neurochem Res 32(8):1375-80. 2007. 
  12. Xie XQ, Zhang P, Tian B*, Chen XQ* (corresponding author). Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke. Mol Neurobiol 2016 Oct 29. DOI:10.1007/s12035-016-0173-z. [Epub ahead of print] PMID:27796760
  13. Chen Y,Liu JM, Xiong XX, Qiu XY, Pan F, Liu D, Lan SJ, Jin S, Yu SB, Chen XQ*. Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP. Oncotarget. 2015 Mar 20; 6(8):6406-21. PMID:25788268
  14. Xiong XX, Liu JM, Qiu XY, Pan F, Yu SB, Chen XQ*. Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways. Acta Pharmacol Sin. 2015 Mar; 36(3):362-74
  15. Liu QR, Liu JM, Chen Y, Xie XQ, Xiong XX, Qiu XY, Pan F, Liu D, Yu SB, Chen XQ*. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxid Med Cell Longev. 2014;2014:653732. doi: 10.1155/2014/653732
  16. Qiu XY and Chen XQ*. Neuroglobin: Recent Developments. Biomol Concepts 5(3): 195–208, 2014
  17. XJ Lai, SQ Ye, L Zheng, L Li, QR Liu, SB Yu, Y Pang, S Jin, Q Li, ACH Yu, Chen XQ. Selective 14-­3-­3γ induction quenches p-β-­catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia. Cell Death Dis. 2014 Apr 17;5:e1184. doi: 10.1038/cddis.2014.152
  18. Li L, Liu QR, Xiong XX, Liu JM, Lai XJ, Cheng C, Pan F, Yu SB, Yu AC, Chen XQ*. Neuroglobin Promotes Neurite Outgrowth via Differential Binding to PTEN and Akt. Mol Neurobiol 49(1):149-62, 2014.
  19. Liu JM, Pan F, Li L, Liu QR, Chen Y, Xiong XX, Cheng K, Yu SB, Shi Z, Yu AC, Chen XQ*. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun 437(1): 87-93, 2013
  20. Zhang J, Lan SJ, Liu QR, Liu JM, Chen XQ*. Neuroglobin, a Novel Intracellular Hexa-coordinated Globin, Functions as a Tumor Suppressor in Hepatocellular Carcinoma Via Raf/MAPK/Erk. Mol Pharmacol 83(3): 1-11, 2013
  21. Ye SQ, Zhou XY, Lai XJ, Zheng L, Chen XQ*. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin 30(7):913-8, 2009
  22. Li D, Chen XQ*, Li WJ, Yang YH, Wang JZ, Yu AC. Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress. Neurochem Res 32(8):1375-80. 2007. 

Courses Taught

1001001 Pathophysiology (undergraduate)

1004231 Disease Basis and Treatment (undergraduate)

510.807 Advanced Pathophysiology (graduate)

510.536 Advanced Methods and Technologies in Neuroscience (graduate)

510.8526 Clinical Pathophysiology (graduate)

Project

 

  1. Role and mechanism of autism-related CHD8 de novo mutation in neurite outgrowth and development,National Natural Science Foundation of China (81471386), 2015-2018
  2. Role of neuroglobin in immune cell infiltration by coupling energy metabolism and EGFR/PTEN/AKT/PD-L1, National Natural Science Foundation of China (81672504), 2017-2020;

 

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