Job title: Professor, Deputy director of the Department of Health and Environmental Hygiene
Academic Areas: Toxicity of Exogenous Compounds and Its Molecular Mechanism
1982.09―1987.07 Bachelor, Department of Health, Hunan Medical University
1989.09―1992.07 Master, Department of Environmental Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
1997.08―1999.10 Medical Doctor, Germany Ulm University
1. Shun Zhang#, Qiang Niu, Hui Gao, Rulin Ma, Rongrong Lei, Cheng Zhang, Tao Xia, Pei Li, Chunyan Xu, Chao Wang, Jingwen Chen, Lixing Dong, Qian Zhao, Aiguo Wang*. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016, 212:97-104.
2. Shun Zhang#, Yihu Chen, Xue Wu, Hui Gao, Rulin Ma, Chunyang Jiang, Gang kuang, Guodong Zhao, Tao Xia, Xiaofei Zhang, Rongrong Lei, Cheng Zhang, Pei Li, Chunyan Xu, Aiguo Wang*. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis. Mol Neurobiol. 2015 (Epub ahead of print).
3. Shun Zhang#, Xiaofei Zhang#, Hongliang Liu, Weidong , Zhizhong Guan, Qiang Zeng, Chunyang Jiang, Hui Gao, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Yushan Cui, Linyu Yu, and Aiguo Wang*. Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China. Toxicol Sci. 2015, 144(2):238-45.
4. Chunyang Jiang#, Shun Zhang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Aiguo Wang*. Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain. Neuromol Med. 2014, 16(1): 94-105.
5. Zhixia Xu#, Bayi Xu, Tao Xia, Weihong He, Ping Gao, Lijuan Guo, Zhenglun Wang, Qiang Niu, Aiguo Wang*. Relationship between intracellular Ca2+ and ROS during fluoride-induced injury in SH-SY5Y cells. Environ Toxicol. 2013, 28(6):307-312.
6. Shun Zhang#, Chunyang Jiang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Hui Gao, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Zhenglun Wang, Aiguo Wang*. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. Toxicol Appl Pharmacol. 2013, 271(2):206-215.
7. Shun Zhang#, Gang Kuang#, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang,, Rulin Ma,, Bei Li,, Lu Yang, Aiguo Wang*. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food Chem Toxicol. 2013.62:699-706.
8. Chunyang Jiang#, Shun Zhang#, HongLiang Liu, Qiang Zeng, Tao Xia, Yihu Chen, Gang Kuang, Guodong Zhao, Xue Wu, Xiaofei Zhang, Aiguo Wang*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro. Toxicol Lett. 2012, 211(3):325-33.
9. Qiang Niu#, HongLiang Liu, ZhiZhong Guan, Qiang Zeng, ShuXia Guo, Ping He, LiJuan Guo, Ping Gao, BaYi Xu, ZhiXia Xu, Tao Xia, Aiguo Wang*. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells. Biol Trace Elem Res. 2012, 149(1):102-9.
10. Bayi Xu#, Zhixia Xu, Tao Xia, Ping He, Ping Gao, Weihong He, Ming Zhang, Lijuan Guo, Qiang Niu, Aiguo Wang*. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells. Environ Toxicol. 2011, 26(1):86-92.
11. Ping He#, Aiguo Wang*, Qiang Niu, Lijuan Guo, Tao Xia, Xuemin Chen. Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats. Toxicol Ind Health. 2011, 27(3):279-88.
Studies on the toxic effects of typical persistent organic pollutants and their underlying mechanisms
The project of Studies on the toxic effects of target persistent organic pollutants and their underlying mechanisms obtained the Second Class Prize for Natural Science of Colleges and Universities of Ministry of Education of China in 2011 and the First Class Prize for Natural Science of Hubei Province of China in 2013.
Summary: The health threats of long residue and cumulative effects of persistent organic pollutants (POPs) on plants, animals and human have drawn great attention. The team, funded by the national project, has mainly focused on the health hazards of target POPs, including polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs), and the associated mechanisms at the whole, molecular and cellular levels.
1． Studies on health hazards, sensitive biological markers and early-warning in population exposed to POPs
(1) The findings of epidemiological study on coke-oven workers are as follows: 1) coke oven emissions exposure increased the internal and external exposure levels of PAHs in coke-oven workers and the levels of PAHs serve as good indicators reflecting the degree of COEs exposure; 2) the argyrophil nucleolar organizer regions (AgNORs) in T lymphocytes of peripheral blood and glutathione S-transferase in serum were first proposed to be good effective biomarkers for monitoring PAHs exposure; 3) multiple indexes, including the frequency of micronuclei in peripheral lymphocytes, heat shock protein 70, BPDE-albumin adduct and the comet tail moment (a product of fraction of DNA in tail and tail length), could be used to measure and alarm the levels of oxidative stress and genetic toxicity resulting from the interactions among PAHs exposure, behavior and genes.
(2) The findings of epidemiological study on Chinese workers from an e-waste recycling site are as follows: 1) the health damages of these workers were associated with the exposure levels of PBDEs, emerging POPs in the living environment. Especially, the elevated levels of serum thyroid-stimulating hormone and frequencies of micronucleated binucleated cells were first reported to be related with high levels of serum PBDEs; 2) exposure to the e-waste recycling environment interfered with the reproductive, endocrine and thyroid hormone systems in mothers and their children.
2. Studies on the single and combined effects of POPs
Given that various POPs coexist in environment and human body, we especially focused on the combined effects of POPs and the underlying mechanisms. The findings are as follows: 1) the synergies were mainly observed in the combined effects of co-exposure to 2, 2′, 4, 4′, 5, 5′-hexachlorobiphenyl (PCB153) or 3, 3′, 4, 4′, 5-pentachlorobiphenyl (PCB126) and benzo (a) pyrene (BaP) or 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47), and PCBs were shown to significantly increase the genetic toxicities of BaP and PBDE-47; 2) the mechanisms by which PCBs enhance the genetic toxicity of BaP were correlated with the alterations in activities of metabolic enzymes and DNA repairing function; 3) in vivo and in vitro studies suggested that PBDE-47 has neurotoxic, developmental neurotoxic and mutagenic effects in Sprague-Dawley rats and human neuroblastoma SH-SY5Y cells, and that oxidative stress and calcium signaling pathways contributed to the mechanisms of PBDE-47-induced neurotoxicity.
The research results of the project were mainly published in high impact journals, including Environmental Health Perspectives, Toxicological Sciences, Environmental Science Technology and Neurotoxicology, which has been positively cited by many journals such as Hepatology、Frontiers in Neuroendocrinology、Environmental Health Perspectives、Mutation Research、Environment International、Environmental Science Technology and Toxicological Sciences. The team has been active in the field of POPs research, and obtained definite international influence and reputation. All the work was conducted and completed by School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.
1. The role of mitochondrial dynamics in the fluorotoxicity and the effect of resveratrol intervention (No. 81430076), the National Natural Science Foundation of key projects, 3.2 million yuan, the project leader.
2. Effects of autophagy and apoptosis on PBDE-47 neurotoxicity (No. 81273021), 2013.1-2016.12, National Natural Science Foundation of China, 70 million yuan, project leader
3. Role of endoplasmic reticulum stress and UPR signaling pathway in PBDE-47 neurotoxicity (No. 81072266), 2011.1-2013.12, National Natural Science Foundation of China, 340,000 yuan, project leader
4. Application of digital PET in the study of neurotoxicity caused by environmental pollutants (No. 0118513100), Huazhong University of Science and Technology 2015 innovation cross key team independent innovation fund, 50 million, project leader