Job title: Professor of Dept. of Nutrition & Food Hygiene

Phone: 86-27-83650523

Email: yingcj@hust.edu.cn

Academic Areas: Nutrition and cardiovascular disease

Research Interests:

Academic Degrees

1982/09-1987/07  Bachelor's Degree of Medicine, The Faculty of Preventive Medicine, Tongji Medical University 

1987/09-1990/07  Master's Degree of Medicine, Dept. of Environmental Health, Tongji Medical University

2004/09-2007/07  Doctoral Degree of Medicine, Dept. of Nutrition & Food Hygiene, Huazhong University of Science & Technology

Professional Experience

1990/07-2002/03  Assistant professor, Lecturer, Associate professor, Dept. of Environmental Health, School of Public Health, Tongji Medical University 

2002/03-2003/04  Sasagawa Clinical Fellowship (Ministry of Health, PRC), Wukogawa Women’s University (Hyogo,JAPAN), 2003/04-2005/03  Associate professor, Dept. of Nutrition & Food Hygiene, Huazhong University of Science & Technology 

2005/03-2006/04  Advanced Sasagawa Clinical Fellowship (Ministry of Health, PRC), Shujitsu University (Okayama,JAPAN )

2006/04-2007/03  Researcher, International Center for Research on Primary Prevention of Cardiovascular Diseases(Kyoto, JAPAN)

2007/03-2008/11  Associate professor, Dept. of Nutrition & Food Hygiene, Huazhong University of Science & Technology

2008/11-present  Professor, Dept. of Nutrition & Food Hygiene, Huazhong University of Science & Technology

Selected Publications

1. He D, Ye X, Xiao Y, Zhao N, Long J, Zhang P, Fan Y, Ding S, Jin X, Tian C, Xu S, Ying C*. Dietary exposure to endocrine disrupting chemicals in metropolitan population from China: A risk assessment based on probabilistic approach.Chemosphere. 2015 May 26;139:2-8. doi: 10.1016/j.chemosphere.2015.05.036.

2. Xuezhi Zuo, Xiaolei Ye, Fangyun Sun, Kun Qian, Siyun Xiang, Wangqun Liang, Gang Xu, Ying Yao, Chenjiang Ying*.Glucose absorption in nephropathy patients receiving continuous ambulatory peritoneal dialysis. ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION . 2015;24(3): 394-402.

3. Yang H, Zuo XZ, Tian C, He DL, Yi WJ, Chen Z, Zhang PW, Ding SB, Ying CJ*. Green Tea Polyphenols Attenuate High-Fat Diet-Induced Renal Oxidative Stress through SIRT3-Dependent Deacetylation. Biomed Environ Sci. 2015 Jun;28(6):455-9. doi: 10.3967/bes2015.064.

4. Liu J, Jin X, Zhao N, Ye X, Ying C*. Bisphenol A promotes X-linked inhibitor of apoptosis protein-dependent angiogenesis via G protein-coupled estrogen receptor pathway. J Appl Toxicol. 2015 Feb 7. 35(11): 1309–1317. doi: 10.1002/jat.3112. [Epub ahead of print]

5. Peng XL, Qu W, Wang LZ, Huang BQ, Ying CJ, Sun XF, Hao LP. Resveratrol Ameliorates High Glucose and High-Fat/Sucrose Diet-Induced Vascular Hyperpermeability Involving Cav-1/eNOS Regulation. PLoS One. 2014 Nov 24;9(11):e113716. doi: 10.1371/journal.pone.0113716.

6. Wang J, Xia W, Xiao Y, Ying C, Long J, Zhang H, Chen X, Mao C, Li X, Wang L,Xu S. Assessment of estrogen disrupting potency in animal foodstuffs of China by combined biological and chemical analyses. J Environ Sci (China). 2014 Oct1;26(10):2131-7. doi: 10.1016/j.jes. 2014.08.013.

7. Ding S, Fan Y, Zhao N, Yang H, Ye X, He D, Jin X, Liu J, Tian C, Li H, Xu S,Ying C*. High-fat diet aggravates glucose homeostasis disorder caused by chronic exposure to bisphenol A. J Endocrinol. 2014 Feb 5.221(1):167-179. [Epub ahead of print] PubMed PMID: 24501380. (Corresponding Author)

8. Zuo X, Tian C, Zhao N, Ren W, Meng Y, Jin X, Zhang Y, Ding S, Ying C, Ye X. Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway. BMC Res Notes. 2014; 7(1):120.

9. Tian C, Jin X, Ye X, Wu H, Ren W, Zhang R, Long J, Ying C*. Long term intake of 0.1% ethanol decreases serum adiponectin by suppressing PPARγ expression via p38 MAPK pathway. Food Chem Toxicol. 2014; 65C:329-334. (Corresponding Author)

10. Fan Y, Ding S, Ye X, Manyande A, He D, Zhao N, Yang H, Jin X, Liu J, Tian C,Xu S, Ying C*. Does Preconception Paternal Exposure to a Physiologically Relevant Level of Bisphenol A Alter Spatial Memory in an Adult Rat? Horm Behav. 2013;64(4):598-604. (Corresponding Author)

11. Tian C, Ye X, Zhang R, Long J, Ren W, Ding S, Liao D, Jin X, Wu H, Xu S, Ying C*.Green Tea Polyphenols Improves Obesity by Up-regulating Adiponectin in High Fat Fed Rats: the Involvement of PPARγ and Erk1/2. PLOS ONE 2013;8(1):e53796. (Corresponding Author)

12. Tian C, Zhang R, Ye X, Zhang C, Jin X, Yamori Y, Hao L, Sun X, Ying C*. Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway. Genes Nutr. 2013;8(2):231-239. (Corresponding Author)

13. Tang, Y., Xu, J., Qu, W., Peng, X., Yang, X., Ying, C., Sun, X., Hao, L. 2011. Resveratrol reduces vascular cell senescense through attenuation of oxidative stress by SIRT1/NAPDH oxidase-dependent mechanisms. J Nutr Biochem. 2012 Nov;23 (11):1410-6.

14. Wei J, Lin Y, Li Y, Ying C, Chen J, Song L, Zhou Z, Lv Z, Xia W, Chen X, Xu S. Perinatal Exposure to Bisphenol A at Reference Dose Predisposes Offspring to Metabolic Syndrome in Adult Rats on a High-Fat Diet. Endocrinology. 2011;152(8):3049-61.

15. Qu W, Zhao L, Peng X, Yang X, Ying C, Hao L, Sun X. Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells: role of the Akt pathway and GLUT4. Diabetes Metab Res Rev. 2011 Jan;27(1):47-53.

16. Yi W, Fu P, Fan Z, Aso H, Tian C, Meng Y, Liu J, Yamori Y, Nara Y, Ying C*. Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats. Nutrition. 2010 Nov-Dec;26(11-12):1176-80. (Corresponding Author)

17. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, Zhang X, Nussler A, Liu L. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol. 2010 Mar 24;128(2):549-53.

18. Zhao LN, Xu J, Peng XL, Tian LY, Hao LP, Yang XF, Ying CJ, Sun XF. Dose and time-dependent hypercholesterolemic effects of iodine excess via TRbeta1-mediated down regulation of hepatic LDLr gene expression. Eur J Nutr. 2010 Aug;49(5):257-65.

19. Wu H, Xu J, Zhuo L, Han L, Bao W, Rong S, Yao P, Ying C, Liu L. Comparison of Risk Factors Associated With Hypertension Subtypes by Classification Tree Method in Tongshan County of Jiangsu Province, China. Am J Hypertens. 2009;22(12):1287-94.

20. Li N, Sun S, Wang D, Yao P, Yang X, Yan H, Du Y, Ying C, Liu L. Suppression of retinoic acid receptors may contribute to embryonic skeleton hypoplasia in maternal rats with chronic vitamin A deficiency. J Nutr Biochem. 2010;21(8):710-6.

21. Liu J, Ying C*, Meng Y, Yi W, Fan Z, Zuo, X, Tian C, Sun X. Green tea polyphenols inhibit plasminogen activator inhibitor-1 expression and secretion in endothelial cells. Blood Coagulation & Fibrinolysis. 2009;20 (7):552-557.(Corresponding Author)

22. Li Y, Ying C*, Zuo X, Yi H, Yi W, Meng Y, Ikeda K, Ye X, Yamori Y, Sun X.. Green tea polyphenols down-regulate Caveolin-1 expression via  ERK1/2 and p38MAPK in endothelial cells. J Nutr. Biochem 2009;20(12):1021-7. (Corresponding Author)

23. Lin J, Zhang M, Song F, Qin J, Wang R, Yao P, Ying C, Hu FB, Liu L. Association between C-reactive protein and pre-diabetic status in a Chinese Han clinical population. Diabetes Metab Res Rev. 2009 Mar;25(3):219-23.

24. Zhao LN, Hao LP, Yang XF, Ying CJ, Yu D, Sun XF. The diabetogenic effects of excessive ethanol: reducing beta-cell mass,decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats. Br J Nutr. 2009;101(10):1467-73.

25. Ying CJ, Noguchi T, Aso H, Ikeda K, Yamori Y, Nara Y. The Role of Cytochrome P- 450 for Salt Sensitive Stroke in Stroke- Prone Spontaneously Hypertensive Rats. Hypertens Res. 2008;31(9):1821-1827.

26. Yang N, Ying C*, Xu M, Zuo X, Ye X, Liu L, Nara Y, Sun X. High-fat diet-fed up-regulates caveolin-1 expression in diet-induced obese but not in diet-resistant rat aorta. Cardiovas Res.2007;76(1):167-174. (Corresponding Author)

27. Ye X, Yan W, Xie H, Zhao M, Ying C*. Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and low-level short-term exposed waiters. Mutat Res. 2005 Dec 7;588(1):22-7. (Corresponding Author)

28. Ying CJ*, Sun XF, Zhang SL, Zhang XP, Mao LM, Zuo XZ, Yao P. ROS-related enzyme expressions in endothelial cells regulated by tea polyphenols. Biomed Environ Sci. 2004;17(1):33-9. (Corresponding Author)

29. Ying CJ, Xu JW, Ikeda K, Takahashi K, Nara Y, Yamori Y. Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II-induced hyperpermeability in endothelial cells. Hypertens Res. 2003;26(10):823-8.

30. Ying CJ*, Ye XL, Xie H, Yan WS, Zhao MY, Xia T, Yin SY. Lymphocyte subsets and sister-chromatid exchanges in the students exposed to formaldehyde vapor.. Biomed Environ Sci. 1999;12(2):88-94. (Corresponding Author)

31. Ying CJ*, Yan WS, Zhao MY, Ye XL, Xie H, Yin SY, Zhu XS. Micronuclei in nasal mucosa, oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class. Biomed Environ Sci. 1997;10(4):451-5. (Corresponding Author)

32. Zhao MY, Ying CJ*, Shao N, Yang Y, Yang CF, Shi L, Liu WQ. The study of health effects of vinyl chloride air pollution on population. Biomed Environ Sci.1994; 7:136-143. (Corresponding Author)

Project

Studies and Previous Research Funding  

1.National Natural Scientific Foundation of CHINA(81172674/H2604), The differential effect mechanism between environmental endocrine disruptors and phytoestrogen on metabolic syndrome, 600,000 Yuan 01/01/2012 - 12/30/2015

2.Specialized Research Fund for the Doctoral Program of Higher Education of China  (20110142110022), The differential effect mechanism between bisphenol A and genistein on cardiovascular diseases, 120,000 Yuan, 01/01/2012 - 12/30/2014

3.National basic research program of China (973 program) (2012CB722401), The effects and mechanism of environmental endocrine disruptors on glucose and lipid metabolism, 300,000 Yuan /2060,000 Yuan 01/01/2012 – 30/12/2014

4.National Natural Scientific Foundation of CHINA(81030051/H2604), Screening of estrogen-like compounds in food and risk assessment of metabolic syndrome, 200,000 Yuan/2100,000 Yuan, 01/01/2011 - 12/30/2014

5.National Natural Scientific Foundation of CHINA (30471461), The effects of caveolin-1 expression and phosphorylation regulations by tea polyphenols on prevention of cardiovascular diseases. 210,000 Yuan, 01/01/2005 - 12/31/2007

6.National Natural Scientific Foundation of CHINA(30972473), Mechanism of Tea Polyphenols on Caveolin-1/Caveolae-mediated Endothelial Permeability, 320,000 Yuan, 01/01/2010 - 12/30/2012

7.Huazhong University of Science & Technology(2011TS116), An novel method for high- throughput metal and protein interaction analysis basced on SPR technology, 100,000 Yuan, 06/01/2011 - 12/30/2012

8.Ministry of Science & Technology of P.R. CHINA, Molecular Control of Vascular Function of Oxidant Stress, 150,000 Yuan/3500,000 Yuan, 12/01/2008 - 12/30/2010

9.Huazhong University of Science & Technology, An novel method for high- throughput cell signaling pathway analysis basced on SPR technology, 40,000 Yuan, 12/01/2008 - 12/30/2010

    
Present Active Research Programs  
 
1.National Natural Scientific Foundation of CHINA(81373007), The study of inducingand dampening mechanism of macrolipophagy in vascular endothelial cells, 700,000 Yuan, 01/01/2014 - 12/30/2017

2.National Natural Scientific Foundation of CHINA(81573160), The roles of Cav-1/SIRT1mediated protein acetylation in the epigenetics via paternal bisphenol A exposure, 598,000 Yuan, 01/01/2016-12/30/2019

3.Huazhong University of Science & Technology(2015ZHYX017), The effects of gut microflora on protein-bound uremic toxins based on a peritoneal dialysis cohort, 70,000 Yuan, 05/01/2015 - 12/30/2016

 

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