Job title: Professor of School of Public Health

Phone: 086-27- 83739569

Email: /

Academic Areas: metabolic function of genes in the hypothalamus

Research Interests:

  We are interested in understanding the role of central nervous system, particularly hypothalamus, in the regulation of systemic energy balance. Specifically, we are interested to characterize the metabolic function of genes in the hypothalamus by combinatorially using high-throughput DNA sequencing, genetically engineered mice, metabolic phenotyping and biochemical approaches; elucidate the role of genes or loci identified through large scale genome-wide association study (GWAS); identify and characterize novel genes controlling whole-body energy balance by proteomic approach. The results of our study will help to identify novel drug targets to treat obesity and/or obesity-related syndrome

Academic Degrees

2005  Ph.D. Cell Biology Peking Union Medical College/Chinese Academy of Medical Sciences
2000  B.Sc. Biochemistry Jilin University

Professional Experience

2014- Professor School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

2009-2013 Research Fellow Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York

2007-2009 Research Associate Department of Physiology, University of Wisconsin-Madison, Madison, Wisconsin

2006-2007 Postdoctoral Associate Department of Animal Science, University of Vermont, Burlington, Vermont

Selected Publications

1. Zhang G*, Li J*, Purkayastha S*, Tang Y*, Zhang H*, Yin Y, Li B, Liu G, Cai D.Nature, 2013; 497(7448): 211-6.Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH.

2. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D.Nature Immunology. 2015; 16(5): 525-33.Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.

3. Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D.Neuron. 2011; 69(3): 523-35.Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.

4. Purkayastha S*, Zhang G*, Cai D.Nature Medicine. 2011; 17(7): 883-7.Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB.

5. Zhang G, Cai D.American Journal of Physiology - Endocrinology and Metabolism. 2011; 301(5): E1004-12.Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment.

6. Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D.PLoS Biology. 2011; 9(7): e1001112.Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.

7. Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D.Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(7):
2939-44.Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress.

8. Zhang G*, Zhu H*, Wang Y, Yang S, Liu M, Zhang W, Quan L, Bai J, Liu Z, Xu N.Biological Chemistry. 2009; 390(5-6) :463-9. Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines.

9. Zhang X*, Zhang G*, Zhang H*, Karin M, Bai H, Cai D. Cell. 2008; 135(1): 61-73. Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity.

10. Zhang G*, Zhou X*, Xue L, Quan L, Wang Y, Zhou C, Lu N, Wang Q, Zhu H, Xu N. Pathology International. 2005; 55(6): 310-7. Accumulation of cytoplasmic β-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: immunohistochemical study.* Equal contribution.

Awards and Honors

2014- 1000 Young Talents Program


2016- National Natural Science Foundation of China - General Program
2016- National Natural Science Foundation of China - Major Plan (Preliminary Program)

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