Job title: Professor

Phone: 15527327819

Email: haoyi@hust.edu.cn

Academic Areas: Pathogenic Biology

Research Interests:

Academic Degrees

 

2002 – 2006

PhD in Immunology, B2M – UniversitéParis 7 - Denis Diderot, Paris, France

2001 – 2002

Master II (Diplômed’EtudesApprofondies, DEA) of “Immunology: Genetic and Molecular Bases of Normal and Pathologic Immune System”, UniversitéParis 5 – René Descartes, Paris, France

1995 – 2000

 

Medical Doctor, Tongji Medical College of Huazhong University of Science and Technology (formerly Tongji Medical University), Wuhan, Hubei, China

 

Professional Experience

 

10/2015 - present

Professor–Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

01/2012 – 09/2015

Research Scientist – Inserm U1151 Team 12 (Weill and Reynaud lab), Institut Necker EnfantsMalades, Paris, France

  • Project: the antigen-experienced B cell compartment.

2007 - 2011

 

Post-doctoral researcher – Michael Cancro lab, University of Pennsylvania, Philadelphia, PA, USA

  • Project: age-related B cell homeostatic changes.

2007

 

Post-doctoral researcher - Inserm U542 (supervisor: Yuchun LONE), Paris, France

  • Project: participation in the creation of humanized mouse model to develop the vaccination.

2002 - 2006

 

PhD student - Lymphocyte Population Biology Unit (Dir.: Antonio FREITAS), Pasteur Institute, Paris, France

  • Project: mechanisms of lymphocyte (CD8+ T cells and B cells) selection and survival in the periphery.

2001 - 2002

 

Master II (DEA) student - INSERM U25 (Dir. Jean-François BACH, supervisor: Claude CARNAUD), Hôpital NeckerEnfantsMalades, Paris, France

  • Project: functional study of PrPc(prion protein) on T lymphocytes: defining a co-stimulation role.

1999 - 2000

 

MD student - Tongji Hospital, Wuhan, China

  • Rotating clinical internship in medicine.

 

Selected Publications

 

  1. Zhou L, Tuo Y, Hao Y, Guo X, Tang W, Xue Y, Zeng J, Zhou Y, Xiang M, Zuo J, Yao G, Zhang Y.Cinnamomols A and B, ImmunostimulativeDiterpenoids with a New Carbon Skeleton from the Leaves of Cinnamomum cassia.Org Lett. 2017 Jun 2;19(11):3029-3032.
  2. Russell Knode LM, Naradikian MS, Myles A, Scholz JL, Hao Y, Liu D, Ford ML, Tobias JW, Cancro MP, Gearhart PJ. Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation. J Immunol. 2017 Mar 1; 198 (5) 1921-1927
  3. Naradikian MS, Hao Y, Cancro MP. Age-associated B cells: key mediators of both protective and autoreactive humoral responses. Immunol Rev. 2016 Jan;269(1):118-29
  4. Weill JC, Le Gallou S, Hao Y, Reynaud CA. Multiple players in mouse B cell memory. CurrOpinImmunol. 2013 Jun;25(3):334-8.
  5. Pan X, Papasani M, Hao Y,Calamito M, Wei F, Quinn III WJ, Basu A, Wang J, Hodawadekar S, Zaprazna K, Liu H, Shi Y, Allman D, Cancro M, Atchison ML.YY1 controls Igκ repertoire and B-cell development, and localizes with condensing on the Igκ locus. EMBO J. 2013 Apr 17; 32(8):1168-82.
  6. Montaudouin C, Anson M, Hao Y, Duncker SV, Fernandez T, Gaudin E, Ehrenstein M, Kerr WG, Colle JH, Pierre Bruhns P, Daëron M, Freitas AA.Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J Immunol,2013 Jan 1;190(1):106-14.
  7. HaoY, Oropallo MA, ScholzJL, CancroMP.New cells in old mice: the ABCs of  humoralimmunosenescence. Open Longevity Science, 2012, 6, 112-120.
  8. HaoY, O’NeillPJ, Naradikian MS, ScholzJL, CancroMP.A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood, 2011 Aug 4;118(5):1294-304.
  9. Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND, Freitas AA, Cumano A, Vieira P.CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol. 2010 May 15;184(10):5678-85.
  10. Cancro MP, Hao Y, Scholz JL, Riley RL, Frasca D, Dunn-Walters DK, Blomberg BB.B cells and aging: molecules and mechanisms. Trends Immunol. 2009 Jul;30(7):313-8.
  11. Treml JF, Hao Y,Stadanlick JE, Cancro MP.The BLyS family: toward a molecular understanding of B cell homeostasis. Cell BiochemBiophys. 2009;53(1):1-16.
  12. Crowley JE, Scholz JL, Quinn WJ 3rd, Stadanlick JE, Treml JF, Treml LS, Hao Y, Goenka R, O'Neill PJ, Matthews AH, Parsons RF, Cancro MP.Homeostatic control of B lymphocyte subsets.  Immunological Res. 2008;42(1-3):75-83.
  13. Lampropoulou V, Hoehlig K, Roch T, Neves P, Calderón Gómez E, Sweenie CH, Hao Y, Freitas AA, Steinhoff U, Anderton SM, Fillatreau S.TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol. 2008 Apr 1;180(7):4763-73.
  14. Hao Y, Legrand N, Freitas AA.The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J Exp Med. 2006 Jul 10;203(7):1643-9.
  15. Gaudin E, Hao Y, Rosado MM, Chaby R, Girard R, Freitas AA.Positive Selection of B Cells Expressing Low Densities of Self-reactive BCRs. J Exp Med. 2004 Mar 15;199(6):843-53.

 

Awards and Honors

FELLOWSHIP

2012 &2013

Grant for confirmed postdoc fellow – LigueNationaleContre le Cancer, France

2006

Pasteur-Weizmann fellowship, France

2005 & 2006

Grant for young researchers – FondationRechercheMedicale (FRM), France

2003 & 2004

Grant for youngresearchers – L’Association pour la Recherche sur le Cancer (ARC).

 
COMMUNITY INVOLVEMENTS

2014- present

Membership of AAI (the American Association of Immunologists)

2014- present

Membership of SFI (the French Society for Immunology)

2004 – 2005

Vice-president of StaPa (the Pasteur Institute young researcher association).

2003 – 2004

General Secretary of AMBCF (association of Chinese doctors&biologists in France).

 

Project

 

  1. Zhou L, Tuo Y, Hao Y, Guo X, Tang W, Xue Y, Zeng J, Zhou Y, Xiang M, Zuo J, Yao G, Zhang Y.Cinnamomols A and B, ImmunostimulativeDiterpenoids with a New Carbon Skeleton from the Leaves of Cinnamomum cassia.Org Lett. 2017 Jun 2;19(11):3029-3032.
  2. Russell Knode LM, Naradikian MS, Myles A, Scholz JL, Hao Y, Liu D, Ford ML, Tobias JW, Cancro MP, Gearhart PJ. Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation. J Immunol. 2017 Mar 1; 198 (5) 1921-1927
  3. Naradikian MS, Hao Y, Cancro MP. Age-associated B cells: key mediators of both protective and autoreactive humoral responses. Immunol Rev. 2016 Jan;269(1):118-29
  4. Weill JC, Le Gallou S, Hao Y, Reynaud CA. Multiple players in mouse B cell memory. CurrOpinImmunol. 2013 Jun;25(3):334-8.
  5. Pan X, Papasani M, Hao Y,Calamito M, Wei F, Quinn III WJ, Basu A, Wang J, Hodawadekar S, Zaprazna K, Liu H, Shi Y, Allman D, Cancro M, Atchison ML.YY1 controls Igκ repertoire and B-cell development, and localizes with condensing on the Igκ locus. EMBO J. 2013 Apr 17; 32(8):1168-82.
  6. Montaudouin C, Anson M, Hao Y, Duncker SV, Fernandez T, Gaudin E, Ehrenstein M, Kerr WG, Colle JH, Pierre Bruhns P, Daëron M, Freitas AA.Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J Immunol,2013 Jan 1;190(1):106-14.
  7. HaoY, Oropallo MA, ScholzJL, CancroMP.New cells in old mice: the ABCs of  humoralimmunosenescence. Open Longevity Science, 2012, 6, 112-120.
  8. HaoY, O’NeillPJ, Naradikian MS, ScholzJL, CancroMP.A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood, 2011 Aug 4;118(5):1294-304.
  9. Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND, Freitas AA, Cumano A, Vieira P.CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol. 2010 May 15;184(10):5678-85.
  10. Cancro MP, Hao Y, Scholz JL, Riley RL, Frasca D, Dunn-Walters DK, Blomberg BB.B cells and aging: molecules and mechanisms. Trends Immunol. 2009 Jul;30(7):313-8.
  11. Treml JF, Hao Y,Stadanlick JE, Cancro MP.The BLyS family: toward a molecular understanding of B cell homeostasis. Cell BiochemBiophys. 2009;53(1):1-16.
  12. Crowley JE, Scholz JL, Quinn WJ 3rd, Stadanlick JE, Treml JF, Treml LS, Hao Y, Goenka R, O'Neill PJ, Matthews AH, Parsons RF, Cancro MP.Homeostatic control of B lymphocyte subsets.  Immunological Res. 2008;42(1-3):75-83.
  13. Lampropoulou V, Hoehlig K, Roch T, Neves P, Calderón Gómez E, Sweenie CH, Hao Y, Freitas AA, Steinhoff U, Anderton SM, Fillatreau S.TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol. 2008 Apr 1;180(7):4763-73.
  14. Hao Y, Legrand N, Freitas AA.The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J Exp Med. 2006 Jul 10;203(7):1643-9.
  15. Gaudin E, Hao Y, Rosado MM, Chaby R, Girard R, Freitas AA.Positive Selection of B Cells Expressing Low Densities of Self-reactive BCRs. J Exp Med. 2004 Mar 15;199(6):843-53.

 

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