Job title: Dean of Family Planning Research Institute of HUST

Phone: +86-27-83693513

Email: aihua_liao@sina.com

Academic Areas: Reproductive Immunology

Research Interests: Immunological and metabolic-immunological pathogenesis of pregnancy-related diseases (e.g. pre-eclampsia, recurrent miscarriage, repeated implantation failure); Immune-privilege mechanism of testis

In 2006, I set up one of the earliest reproductive immunology unit in China. A major focus of my scientific interest is on reproductive immunology, with particular regard to the establishment and maintenance of normal maternal-fetal immune tolerance, and the immunological or metabolic-immunological pathogenesis and therapeutic strategies on the pregnancy related diseases (including pre-eclampsia, recurrent miscarriage and repeated implantation failure after IVF-ET). Especially, our team pay more attention to clarifying the underlying mechanism of the above-mentioned pregnancy complications with regards to (i) the Treg/Th17 balance, (ii) macrophage polarization, (iii) PD-1/PD-L1 and Tim-3/Gal-9 signaling pathway, and (iv) the regulation of vitamin D, and to determining the roles of PD-1/PD-L1 signaling pathway in the privileged sites as testis. Also, we focus on exploring the therapeuticstrategies targeting the PD-1/Tim-3 signaling pathway on pregnancy-related diseases.

Academic Degrees

M.D., Ph.D

Professional Experience

Professor (2009-present); Family Planning Research Institute, HUST, Wuhan, China

Visiting scholar (08.2012-11.2012); Reproductive Medicine, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA (Mentor: Prof. Dr. Joanne Kwak-Kim)

Associate professor (2004-2009); Family Planning Research Institute, HUST, Wuhan, China

Visiting scholar (05.2003-02.2005); Immunology Institute, University Hospital of Duisberg-Essen, Essen, Germany (Mentor: Prof. Dr. Hans Grosse-Wilde)

Lecturer (1996-2003); Family Planning Research Institute, HUST, Wuhan, China

Selected Publications

Zhang YH, He M, Wang Y, Liao AH* (2017). Modulators of the Balance between M1 and M2 Macrophages during Pregnancy. Front Immunol, 8:120.

Wang LL, Li ZH, Hu XH, Muyayalo KP, Zhang YH, Liao AH* (2017). The roles of the PD-1/PD-L1 pathway at immunologically privileged sites. Am J Reprod Immunol, e12710.

Ji JL, Muyayalo KP, Zhang YH, Hu XH, Liao AH* (2017). Immunological function of vitamin D during human pregnancy. Am J Reprod Immunol, e12716.

Liu ZZ, Sun GQ, Hu XH, Kwak-Kim J, Liao AH* (2017). The transdifferentiation of regulatory T and Th17 cells in autoimmune/inflammatory diseases and its potential implications in pregnancy complications. Am J Reprod Immunol, e12657.

Hu XH, Tang MX, Mor G, Liao AH* (2016). Tim-3: Expression on immune cells and roles at the maternal-fetal interface. J Reprod Immunol, 118:92-99.

Tian M, Zhang Y, Liu Z, Sun G, Mor G, Liao A* (2016). The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Sci Rep, 6:27683.

Mao-Xing Tang, Xiao-Hui Hu, Zhao-Zhao Liu, Joanne Kwak-Kim, Ai-Hua Liao* (2015). What are the roles of macrophages and monocytes in human pregnancy? J Reprod Immuno, 112:73-80.

Zhang XH, Liu ZZ, Tang MX, Zhang YH, Hu Lian, Liao AH* (2015). Morphological Changes and Cytokine Expression after Local Endometrial Injury in a Mouse Model. Reprod SCI, 22(11):1377-86.

Tang MX, Zhang YH, Hu Lian, Kwak-Kim J, Liao AH* (2015). CD14++CD16+HLA-DR+ Monocytes in Peripheral Blood are Quantitatively Correlated with the Severity of Pre-eclampsia. Am J Reprod Immunol, 74(2):116-22.

Zhang YH, Tian M, Tang MX, Liu ZZ, Liao AH* (2015). Recent Insight into the Role of the PD-1/PD-L1 Pathway in Feto–Maternal Tolerance and Pregnancy. Am J Reprod Immunol, 74(3):201-8.

Zhang Y, Kwak-Kim J, Huang D, Hu L, Liao A* (2014). Cyclic Changes and Relationship between Peripheral and Endometrial NK Cells from Women with Repeated Failure after Artificial Insemination by Donor Sperm.

Am J Reprod Immunol, 71(1):44-54.

Zeng B, Kwak-Kim J, Liu Y, Liao AH* (2013). Treg Cells Are Negatively Correlated with Increased Memory B Cells in Pre-eclampsia While Maintaining Suppressive Function on Autologous B-Cell Proliferation. Am J Reprod Immunol, 70(6):454-463.

Kwak-Kim J, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, Beaman K, Kim JW, Gilman-Sachs A (2013). Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. Am J Reprod Immunol, 69(6):596-607.

Lu Y, Zhang F, Zhang Y, Zeng B, Hu L, Liao A* (2013). Quantitative reduction of peripheral CD4+CD25+FOXP3+ regulatory T cells in reproductive failure after artificial insemination by donor sperm.

Am J Reprod Immunol, 69(2):188-193.

Hu L, Liao AH*, Song S, Xiao N, Xiang WP, Xiong CL (2012). Evaluation of donor semen quality provided by six sperm banks: a retrospective study of 1877 artificial insemination cycles. Andrologia, 44 Suppl 1:499-504.

Lu Y, Zeng B, Zhang Y, Xiang W, Hu L, Liao A*(2011). Quantitative and functional changes in peripheral natural killer cells in women with reproductive failure after artificial insemination with donor sperm. J Reprod Immunol, 91(1-2): 83-89.

Li-Ping Liu, Wei Huang, Yue-chao Lu, Ai-Hua Liao* (2010). Enhanced maternal anti-fetal immunity contributes to the severity of hypertensive disorder complicating pregnancy.Am J Reprod Immunol, 63(5): 379-386.

Liao AH*, Liu LP, Ding WP, Zhang L (2009). Functional changes of human peripheral B-lymphocytes in pre-eclampsia. Am J Reprod Immunol, 61(5):313-21.

Li HG, Huang SY, Zhou H, Liao AH*, Xiong CL (2009). Quick recovery and characterization of cell-free DNA in seminal plasma of normozoospermia and azoospermia: implications for non-invasive genetic utilities. Asian J Androl, 11(6):703-9.

Zhang L, Wang Y, Liao AH* (2008). Quantitative abnormalities of fetal trophoblast cells in maternal circulation in preeclampsia. Prenat Diagn, 28(12): 1160-1166.

Conference reports:

Kinetics of Tim3+CD4+Foxp3+ regulatory T cells during pregnancy in mice. In: 36th Annual Meeting of the American Society for Reproductive Immunology, Novmember 12-16, 2016; Baltimore, USA.

Relationship between the PD- 1/PD- L1 pathway and Treg/Th17 imbalance in preeclampsia and the protective effects of PD- L1Fc on pre- eclamptic rats.In: 36th Annual Meeting of the American Society for Reproductive Immunology, Novmember 12-16, 2016; Baltimore, USA.

PD-1 pathway regulates Treg/Th17 imbalance by interfering cell proliferation in pre-eclampsia. In: 13th Congress of the International Society for Immunology of Reproduction (ISIR) and the European Society for Reproductive Immunology (ESRI), June 22-25, 2016; Erfurt, Germany.

Apoptosis of CD4+CD25+ Treg cells is increased in pre-eclampsia. In: 35th Annual Meeting of the American Society for Reproductive Immunology, June 2-5, 2015; Kingston, Canada.

Expression of PD-1 and PD-L1 on peripheral Treg and Th17 cells in women with pre-eclampsia. In: 35th Annual Meeting of the American Society for Reproductive Immunology, June 2-5, 2015; Kinetic, Canada.

Clinical and basic research on lymphocyte immunotherapy for reproductive failures in China. In: 21th Conference of Korean Study Group for Reproductive Immunology (KSGRI), March 22-23, 2014, Incheon, Korea.

Working Papers

Books

<<Reproductive Diseases>>, Fujian Scientific Technology Publishing, 2007,co-chief editor

<<Female Infertility>>, People's Medical Publishing House, 2012,chief editor

Awards and Honors

Member of International Society for Immunology of Reproduction, 2011 to present.

Member of American Society for Immunology of Reproduction, 2013 to present.

Member of National Society for Immunology in China, 2010 to present.

Associate secretary of Sexual Society in Hubei Province, 2010 to present.

Member of Reproductive Medical Association in Hubei Province, 2009 to present.

Courses Taught

contraception and sterility, human assisted reproductive technology, clinical reproductive medicine, and sex and human reproduction.

Project

Mechanism of PD-1/Tim-3 signal moleculars regulating the polarization of decidual macrophages on the pathogenesis of pre-eclmpsia, supported by National Natural Science Foundation (No. 81671490), Principal investigator

Mechanism of PD-1/PDL-1 signal pathway regulating Treg/Th17 cell balance on the pathogenesis of pre-eclmpsia, supported by National Natural Science Foundation (No. 81471475), Principal investigator

Clinical implication and mechanism of Vitamin D supplementation on repeated implantation failure, supported by Merck Serono China Research Fund
for Fertility (NO.0231519043), Principal investigator

PD-1/PDL-1 signal pathway on the pathogenesis of pre-eclmpsia in rat model and the treatment efficacy of PD-L1:Fc, supported by Fundamental Research Funds for the Central Universities (No. 2014ZHYX017), Principal investigator

Cyclic changes of peripheral and endometrial NK cells by endometrial scratching for repeated reproductive failure after artificial insemination by donor sperm, supported by Fundamental Research Funds for the Central Universities (No. 2012TS025), Principal investigator

Regulation of Treg cells on B cells in the pathogenesis of pr-eclampsia, supported by National Natural Science Foundation (No. 81070507), Principal investigator

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Address:No.13,Wuhan,Hankou City.Hubei Province,zip code:430030 e ICO 030193