Job title: Professor

Phone: 86(27)15972138902

Email: qinghuaa@mails.tjmu.edu.cn

Academic Areas: respiratory diseases

Research Interests: pulmonary hypertension, chronic obstructivepulmonary disease,calcium signaling and gene expression

Academic Degrees

PhD in Department of Pathphysiology, 1994, Tongji Medical University, P.R.China

MD in Clinical Medicine, 1989, Tongji Medical University, P.R.China

Professional Experience

Professor (2007.01-present), Tongji Medical College, Huazhong University of Science and Technology

Vice Director (2004.05-present), Key Laboratory of Pulmonary Diseases of Ministry of Health of China 

Chair Professor (part-time) (2004.05-2006.12), Tongji Medical College, Huazhong University of Science and Technology

Assistant Professor (tenure-track) (2002.07-2006.12), Johns Hopkins University School of Medicine, Baltimore, Maryland

Instructor (2000.01-2002.06), Johns Hopkins University School of Medicine, Baltimore, Maryland

Guest Researcher (1997.07-2003.10), National Institute on Aging/NIH, Baltimore, Maryland

Postdoctoral Fellow (1996.08-1999.12), Johns Hopkins University School of Medicine, Baltimore, Maryland

Associate Professor (1995.11-1996.07), Tongji Medical University

Lecturer(1994.08-1995.10), Tongji Medical University

Selected Publications

  1. Zhu L, Zhang J, Zhou J, Lu Y, Huang S, Xiao R, Yu X, Zeng X, Liu B, Liu F, Sun M, Dai M, Hao Q, Li J, Wang T, Li T, Hu Q*. Mitochondrial Transplantation Attenuates Hypoxic Pulmonary Hypertension. Oncotarget. 2016 Jul 13. doi: 10.18632/oncotarget.10596. (IF= 6.368) 
  2. Zhou J, Zhang J, Lu Y, Huang S, Xiao R, Zeng X, Zhang X, Li J, Wang T, Li T, Zhu L, Hu Q*. Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction. Oncotarget. 2016 Apr 21. doi: 10.18632/oncotarget.8893. (IF= 6.368)
  3. Su Y, Zhu L, Yu X, Cai L, Lu Y, Zhang J, Li T, Li J, Xia J, Xu F, Hu Q*. Mitochondrial transplantation attenuates airway hyperresponsiveness by inhibition of cholinergic hyperactivity. Theranostics. 2016, 6(8): 1244-1260.  (IF= 8.854)
  4. Chen F, Zhu L, Cai L, Zhang J, Zeng X, Li J, Su Y, Hu Q*. A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca2+ signaling. BiochimBiophysActa-Mol Cell Res. 2016, 1863(4): 617-629. (IF= 5.128)
  5. Li J, Peng X, Zeng X, Liu B, Hao Q, Yu X, Zhu L, Hu Q*. Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application. Sci Rep. 2015, 5:15286. (IF=5.578)
  6. Peng X, Li J, Yu X, Tan R, Zhu L, Wang J, Wang R, Gu G, Liu Q, Ren L, Wang C, Hu Q*. Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model. Thromb Res. 2015, 135(5): 990-999. (IF=2.447)
  7. Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K, Hu Q*. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. Cardiovasc Res. 2013, 100(1): 19-27. (IF=5.940) 
  8. Zhang J, Zhou J, Cai L, Lu Y, Wang T, Zhu L, Hu Q*. Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. Antioxid Redox Signal. 2012, 17(3): 471-484. (IF= 8.456)
  9. Song S, Li J, Zhu L, Cai L, Xu Q, Ling C, Su Y, Hu Q*. Irregular Ca2+ wscillations regulate transcription via cumulated spike duration and spike amplitude. J Biol Chem. 2012, 287(48): 40246-40255. (IF= 4.773)
  10. Zhu L, Song S, Pi Y, Yu Y, She W, Ye H, Su Y, Hu Q*. Cumulated Ca2+ spike duration underlines Ca2+ oscillation frequency-regulated NF-kB transcriptional activity. J Cell Sci. 2011, 124: 2591-2601. (IF= 6.111)
  11. Chen T, Zhu L, Wang T, Ye H, Huang K, and Hu Q*. Mitochondria depletion abolishes agonist-induced Ca2+ plateau in airway smooth muscle cells: potential role of H2O2. Am J Physiol Lung Cell Mol Physiol. 2010, 298: L178-188. (IF=4.043)
  12. Zhu L, Luo Y, Chen T, Chen F, Wang T, Hu Q*. Ca2+ oscillation frequency regulates agonist-stimulated gene expression in vascular endothelial cells. J Cell Sci. 2008, 121: 2511-2518. (IF= 6.111)
  13. Ziegelstein RC, Xiong Y, He C, Hu Q*. Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cells. BiochemBiophy Res Commun. 2006, 342(1): 153-163. (IF= 2.484)
  14. Zhang S, Wang S, Li Q, Yao S, Zeng B, Ziegelstein RC, Hu Q*. Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled study. Lancet. 2005, 366(9485): 556-562. (IF= 38.278)
  15. Jin S, Lu D, Ye S, Ye H, Zhu L, Feng Z, Liu S, Wang D, Hu Q*. A simplified probe preparation for ELISA-based NF-κB activity assay. J BiochemBiophys Methods. 2005, 65(1): 20-29. (IF= 1.994)
  16. Ziegelstein RC, He C and Hu Q*. Hypoxia/reoxygenation stimulates Ca2+-dependent ICAM-1 mRNA expression in human aortic endothelial cells. BiochemBiophys Res Commun. 2004, 322(1): 68-73. (IF= 2.484)
  17. Hu Q*, Yu Z, Ferrans VJ, Takeda K, Irani K, Ziegelstein RC. Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in Human aortic endothelial cells stimulated by histamine. J Biol Chem. 2002, 277(36): 32546-32551. (IF= 4.773)
  18. Hu Q, Ziegelstein RC. Hypoxia/Reoxygenation induces intracellular calcium oscillations in human aortic endothelial cells. Circulation. 2000, 102: 2541-2547. (IF=14.739)
  19. Hu Q, GeminZheng, Zwiever JL, Deshpande S, Irani K, Ziegelstein RC. NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to InsP3 in human endothelial cells. J Biol Chem. 2000, 275: 15749-15757. (IF= 4.773)
  20. Hu Q, Deshpande S, Irani K, Ziegelstein RC. [Ca2+]i oscillation frequency regulates agonist-stimulated NF-κB transcriptional activity. J Biol Chem. 1999, 274(48): 33995-33998. (IF= 4.773)
  21. Hu Q, Xia Y, Corda S, Zwiever JL, Ziegelstein RC. Hydrogen peroxide decreases intracellular pH in human aortic endothelial cells by inhibiting Na+/H+ exchange. Circ Res. 1998, 83: 644-651. (IF= 9.489)
  22. Hu Q, Corda S, Zwiever JL, Capogrossi MC, Ziegelstein RC. Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells. Circulation. 1998, 97:268-275. (IF=14.739)

Courses Taught

Pathophysiology (undergraduate)

Research Progress of Pathophysiology (undergraduate)

Clinical Pathophysiology (postgraduate)

Advanced Pathophysiology (doctoral candidate)

Project

  1. Diagnosis and therapy of complication of chronic obstructive pulmonary disease, National key research and development program, 2016-2020.
  2. Molecular classification of chronic pulmonary obstructive disease, National key research and development program, 2016-2019.
  3. Extracellular calcium-sensing receptor and pulmonary hypertension, NationalNatural Science Foundation of China (major project), 2014-2018.
  4. Mutated-STIM1 and nuclear calcium signaling, NationalNatural Science Foundation of China (general project), 2014-2017.
  5. Mitochondrial heterogeneity and hypoxic pulmonary hypertension,NationalNatural Science Foundation of China (general project), 2012-2015.
  6. Gender of bone marrow-derived mesenchymal stem cells and pulmonary hypertension, NationalNatural Science Foundation of China (general project), 2010-2012.
  7. Extracellular calcium-sensing receptor and hypoxic pulmonary vasoconstriction, NationalNatural Science Foundation of China (general project), 2007-2009.
  8. Mitochondria in membrane receptor-mediated nuclear gene expression, National Natural Science Foundation of China (general project), 2005-2007.
  9. Oxygen-sensitive potassium channels of pulmonary arterial smooth muscle cells, NationalNatural Science Foundation of China (general project), 1998-2000.
  10. Antisense oligonucleotide inhibits thromboxane synthase gene expression and TXA2 production, NationalNatural Science Foundation of China (youth project), 1995-1997.

 

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