Time

May 12th. Wednesday, early UK morning, like 8:00 am

Speaker

Dr. Daniel Fulton, Dr. Pei Lei

Participating scholars (excluding students)

Dr. Zhu Houze, Dr. Zhang Tongmei, Dr. Li Xinyan, Dr. Zhang Pei

Host

Dr. Li Hao

School of Basic Medicine, Tongji Medical College, HUST

ZOOM （Zoom link）

We will use the common account of the International Exchange Office of Huazhong University of Science and Technology

Introduction of the lecture（100 words or less）

(1)Dr. Daniel Fulton

Title: 3-dimensional analysis of oligodendrocyte myelination, injury and plasticity in organotypic brain slice cultures

Introduction: In vivo imaging in mouse neocortex has revealed the dynamic behaviour of glial cells. Microglial processes constantly survey the local environment, while oligodendrocyte (OL) differentiate and myelinate axons in response to sensory stimuli. However, in vivo observations are limited to outer neocortical regions falling within the reach of 2-photon imaging, and information on glial behaviours in deep lying brain regions remain unknown. In this talk he will describe how his group uses organotypic slice cultures to image OL behaviours in deeper lying regions including cerebellar white matter and deep neocortical grey and white matter. he will present their recent findings on activity-dependent myelination, and describe a novel method they are using to live-image myelination in subcortical white matter.

(2) Dr. Pei Lei

Title: The role of PVT PKR2 neurons in ketamine general anesthesia

Introduction: Ketamine is the most unique anesthetic agent used today. With considerably diverse molecular targets and neurophysiological properties, ketamine’s effects on the central nervous system in general anesthesia remain incompletely understood. In this talk, Dr. Pei will introduce his recent study on the molecular and cellular mechanisms of ketamine general anesthesia. He used different approaches demonstrated that the PKR2 neurons in anterior part of paraventricular nucleus (aPVT) modulates wakefulness from ketamine general anesthesia. 

Introduction of the keynote speaker

Daniel Fulton is a Lecturer in Glial Biology based in the Neuroscience, Trauma and Ophthalmology group of the Institute of Inflammation and Ageing. Dr. Fulton leads the Oligodendrocyte & Myelin research group.

Dr. Pei Lei is the associated Professor in Department of Neurobiology, School of Basic Medicine in Tongji Medical College, Huazhong University of Science and Technology. Now He is working as a visiting Researcher in Department of Anesthesiology from Washington University in Saint Louis.