FANG Chao 

Job title: Full Professor

Phone: 86(27)83692629

Email: fangc@hust.edu.cn

Academic Areas: Cardiovascular Pharmacology

Research Interests: Molecular mechanisms of blood clotting diseases and cardiovascular pharmacology

Academic Degrees

PhD in Pathology, 2014, Case Western Reserve University, Cleveland, OH, USA

MS in Biochemistry and Molecular Biology, 2008, Shanghai Jiao Tong University, Shanghai, China

BS in Life Sciences, 2006, Shanghai Jiao Tong University, Shanghai, China

Professional Experience

Full Professor (2018-present), Department of Pharmacology, Huazhong University of Science and Technology, Wuhan, China

Research Fellow (2014-2018), Harvard Medical School, Boston, MA, USA

Selected Publications

1. Adams, G., Stavrou, E., Fang, C., Merkulova, A., Alaiti, A., Nakajima, K., Morooka, T., Merkulov, S., LaRusch, G.A., Simon, D.I., Jain, M.K. and Schmaier, A.H. Prolylcarboxypeptidase promotes angiogenesis and vascular repair. Blood (2013) Cover story with editorial commentary

2. Wang Y., Fang C., Gao H., Bilodeau M.L., Zhang Z., Croce K., Liu S., Morooka T., Sakuma M., Nakajima K., Shi C., Zidar D., Silverstein R.L., Hogg N., Schmaier A.H., Simon D.I. Platelet-Derived Myeloid Related Protein-14 (S100A9) Regulates Thrombus Formation. J Clin Invest. (2014)

3. Stavrou, E.*, Fang, C.*, Merkulova A., Alhalabi O., Grobe N., Antoniak S., Mackman N., Schmaier, A.H. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. Blood, (2015) Cover story with editorial commentary *equal contributing first authors

4. Lihu Gong*, Valerie Proulle*, Chao Fang*, Zebin Hong, Zhonghui Lin, Min Liu, Cai Yuan, Lin Lin, Barbara Furie, Robert Flaumenhaft, Peter Andreasen, Bruce Furie, Mingdong Huang A Specific Plasminogen Activators Inhibitor-1 Antagonist Derived From Inactivated Urokinase. J Cell Mol Med (2016) *equal contributing first authors

5. Bowley S.R.*, Fang C.*, Furie B.C., Furie B. Protein disulfide isomerase released during thrombus formation cleaves a disulfide bond in plasma vitronectin and enables it to bind to the αVβ3 integrin receptor. Nat Commun. (2017) *equal contributing first authors

6. Evi X. Stavrou, Chao Fang, Kara L. Bane, Andy T. Long, et al. Factor XII - uPAR Upregulate Neutrophil Functions to Influence Wound Healing. J Clin Invest (2018) Cover story

Courses Taught

Pharmacology (undergraduate)

Pharmacology Experiments (undergraduate)

Project

National Natural Science Foundation of China

Ministry of Science and Technology Sino-US Collaborative Grant

American Society of Hematology Global Research Award