WANG JIAN-ZHI

Contacting Information:

Jian-Zhi Wang

Department of Pathology and Pathophysiology

Tongji Medical College

Huazhong University of Science and Technology

13 Hang Kong Road

Wuhan, 430030

P.R. China

Email: wangjz@mail.hust.edu.cn or wangjz@mails.tjmu.edu.cn

Phone: 086-27-83693883   Fax: 086-27-83693883

Position Title:

Professor and Director of Pathophysiology, Key Laboratory of Ministry of Education of China

Academic Areas:

Neurology, pathophysiology and bio-neuropathology

Research Interests:

Alzheimer disease including pathogenesis, early diagnosis and prevention; also interested in emotion and learning memory, neurodevelopment and neural circuitry.

Employment:

1978-1992 Biochemistry Department, Tongji Medical University, Wuhan, China, teaching assistant, lecturer, associate professor

1992-1993  Postdoctoral Research in Biochemistry, Siena University, Siena, Italy

1993-1996 Postdoctoral Research in Alzheimer disease, NYS Institute for Basic Research, SI, NY, USA

1996-    Pathophysiology Department, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China, full professor and mentor of Ph.D students

Education and Training:

1993-1996 Postdoctoral Research in Alzheimer disease, NYS Institute for Basic Research, SI, NY, USA

1992-1993  Postdoctoral Research in Biochemistry, Siena University, Siena, Italy

1989-1990  Visiting scientist, Biochemistry Institute of Shanghai, Chinese Academy of Science

1985-1988  Post Graduate Training in Biochemistry, Tongji Medical University, Wuhan, China, M.S.

1975-1978  Undergraduate Study in General Medicine, Wuhan Medical College (i.e., Tongji Medical College), Wuhan, China, M.D. (equivalence)

Honors:

2014  Selected by the National Ten Thousand Talents Plan

2007  Creative Team Leader for Neurological Disorders, Ministry of Education of China

2007 National Model Teacher for Education

2006  National Prestigious Teacher Award for Teaching

1. Changjiang Distinguished Professor of Ministry of Education of China

   1999  Outstanding-Young Scientist Award, NSFC

    

   Scientific Awards:

   2010   Second-grand Award of Natural Science Research in Alzheimer Disease, the State Council of China

   2009  First-grade Award of Natural Science Research in Alzheimer disease, Ministry of Education of China

   2008  First-grade Award of Natural Science Research in Alzheimer disease, Government of Hubei Province

   2008  Second-grand Award Natural Science Research in Alzheimer disease, Chinese Medical Association

   2004 First-grade Award of Natural Science Research in Alzheimer disease, Ministry of Education of China

   2002  First-grade Award of Chinese Medicine, Chinese Medical Association

   2000 Second-grade Award of in Alzheimer Disease Research, Government of Hubei Province

    

   Professional Memberships:

   2004-2014  Vice Chairperson, Pathophysiology Association of China

   2014-present   Vice Chairperson, International Association of Pathophysiology

   2014-present  Executive Member of Pathophysiology Association of China

   2015-present  Member of Neuroscience Association of China

   2010-present  Chairperson, Pathophysiology Association of Hubei Province

    

   Other Serves:

   1996-present   Ad Hoc reviewer for Natural Science Foundation of China (NSFC), Ministry of Science and Technology of China (MOST), and Ministry of Education of China, etc

   Associate Editor   Neuroscience Bulletin, Frontier of Medicine, Journal of Alzheimer Disease, Journal of Neurochemistry (handling editor), etc.

   Chief Editor   <Pathophysiology>, both in Chinese (6^th, 7^th and 8^th editions), and in English (1^st and 2^nd editions)  

   Courses Taught:

1001001 Pathophysiology (for undergraduates)

1004231 Pathophysiology (for eight-year Program of Clinical Medicine)

1004232 Pathophysiology (For Chinese-German Medicine class)

510807 Advanced Pathophysiology (for postgraduate)

510526 Pathophysiology (for postgraduate)

Ongoing Research Projects:

1. Impairment of medial septum-hippocampus cholinergic circuit in Alzheimer’s spatial memory deficit and the molecular mechanisms. From Natural Science Foundation of China (NSFC), 2017.01-2019. 12.

2. AEP cleaved tau toxicities. From Natural Science Foundation of China (NSFC), 2016.01-2017. 12.

3. Mechanisms and risk factors of Alzheimer’s disease. From Ministry of Science and Technology of China (MOST) 2016.09-2021.08

4. Mechanisms underlying GSK-3beta-mediated Aβ and tau toxicities. From Natural Science Foundation of China (NSFC), 2013.1-2016. 12.

5. Searching for new biomarkers for Alzheimer’s disease. From Ministry of Science and Technology of China (MOST) 2013.09-2016.12

Peer reviewed publications (selected from over 160):

1. Yang Y, Wang ZH, Jin S, Gao D, Liu N, Chen SH, Zhang S, Liu Q, Liu E, Wang X, Liang L, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L, Wang JZ. Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness– and helplessness–modulated spatial learning and memory. Nat Commun. 2016;7:11935. doi:10.1038/ncomms11935.

2. Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3773-81.

3. Li XG, Wang ZH, Tan L, Wang YL, Lu C, Chen R, Zhang SJ, Gao Y, Liu YC, Yin YL, Liu XH, Liu EJ, Yang Y, Hu Y, Xu ZP, Xu FQ, Wang J, Liu GP, Wang JZ. Correcting miR92a-vGAT-mediated GABAergic dysfunctions rescues human tau-induced anxiety in mice. Mol Ther. 2016 In press

4. Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S, Wang XL, Cao FY, Wang XC, Wang JZ, Liu R. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell Death Dis. 2016 Nov 3;7(11):e2449. doi: 10.1038/cddis.2016.329.

5. Hu Y, Li XC, Wang ZH, Luo Y, Zhang X, Liu XP, Feng Q, Wang Q, Yue Z, Chen Z, Ye K, Wang JZ, Liu GP. Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial parkin. Oncotarget. 2016 Mar 2. doi:10.18632/oncotarget.7861.

6. Du LL, Wang L, Yang XF, Wang P, Li XH, Chai DM, Liu BJ, Cao Y, Xu WQ, Liu R, Tian Q, Wang JZ, Zhou XW. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis. Mol Neurobiol. 2016 Feb 24.

7. Li XC, Hu Y, Wang ZH, Luo Y, Zhang Y, Liu XP, Feng Q, Wang Q, Ye K, Liu GP, Wang JZ. Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins. Sci Rep. 2016 Apr 21;6:24756. doi: 10.1038/srep24756.

8. Jin L, Gao LF, Sun DS, Wu H, Wang Q, Ke D, Lei H, Wang JZ, Liu GP. Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3XTg AD Mice. Mol Neurobiol. 2016 Jun 21.

9. Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Sci Rep. 2016 Jun 9;6:27283. doi: 10.1038/srep27283.

10. Zheng C, Zhou XW, Wang JZ. The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ. Transl Neurodegener. 2016 Apr 5;5:7. doi: 10.1186/s40035-016-0054-4. eCollection 2016. Review.

11. Xu ZP ，Yang SL，Zhao S，Zheng CH，Li HH，Zhang Y，Huang RX，Li MZ，Gao Y，Zhang SJ，Zhan PY，Zhang LF，Deng L，Wei S，Liu YC，Ye JW，Ren HJ，Li N，Kong CX，Wang X，Fang L，Zhou QZ，Jiang HW，Li JR，Wang Q，Ke D，Liu GP，Wang JZ. Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case-Control Study. EBioMedicine. 2016,5:105-113.

12. Qu N, Zhou XY, Han L, Wang L, Xu JX, Zhang T, Chu J, Chen Q, Wang JZ, Zhang Q, Tian Q. Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats. Mol Neurobiol. 2016 Mar;53(2):894-904.

13. Li K, Liu FF, He CX, Huang HZ, Xie AJ, Hu F, Liu D, Wang JZ, Zhu LQ. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol. 2016 Jan;53(1):391-401.

14. Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ. 2015 Apr;22(4):583-96.

15. Xiong YS, Liu FF, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ, Zhu LQ. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. Aging Cell. 2015 Oct;14(5):867-77.

16. Jiang X, Chai GS, Wang ZH, Hu Y, Li XG, Ma ZW, Wang Q, Wang JZ, Liu GP. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Neurobiol Aging. 2015 Feb;36(2):867-76.

17. Wu Y, Luo X, Liu X, Liu D, Wang X, Guo Z, Zhu L, Tian Q, Yang X, Wang JZ. Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models. Sci Rep. 2015 Oct 14;5:15032. doi: 10.1038/srep15032.

18. Jiang J, Wang ZH, Qu M, Gao D, Liu XP, Zhu LQ, Wang JZ. Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β. Sci Rep. 2015 Jun 29;5:11765.

19. Li L, Xu ZP, Liu GP, Xu C, Wang ZH, Li XG, Liu EJ, Zeng J, Chai DM, Yao WL, Wang JZ. Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells. PLoS One. 2015 Mar 30;10(3):e0119865.

20. Liu ZC, Chu J, Lin L, Song J, Ning LN, Luo HB, Yang SS, Shi Y, Wang Q, Qu N, Zhang Q, Wang JZ, Tian Q. SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress. Mol Neurobiol. 2016 Mar;53(2):983-94.

21. Xie AJ, Liu EJ, Huang HZ, Hu Y, Li K, Lu Y, Wang JZ, Zhu LQ. Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes. Mol Neurobiol. 2016 Sep;53(7):4992-9.\

22. Du LL, Chai DM, Zhao LN, Li XH, Zhang FC, Zhang HB, Liu LB, Wu K, Liu R, Wang JZ, Zhou XW. AMPK activation ameliorates Alzheimer's disease-like pathology andspatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats. J Alzheimers Dis. 2015;43(3):775-84.

23. Shang XL, Wang QB, Liu XP, Yao XQ, Cao FY, Wang Q, Zhang JY, Wang JZ, Liu GP. Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. Neurosci Lett. 2015 Jan 1;584:230-5.

24. Wang XL, Zeng J, Yang Y, Xiong Y, Zhang ZH, Qiu M, Yan X, Sun XY, Tuo QZ, Liu R, Wang JZ. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. J Alzheimers Dis. 2015;43(1):153-65.

25. Hu J, Huang HZ, Wang X, Xie AJ, Wang X, Liu D, Zhu LQ, Wang JZ. Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments. Mol Neurobiol. 2015 Dec;52(3):1601-17.

26. Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC, Wang JZ. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16586-16591.

27. Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K*. Cleavage of tau by asparagineendopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nat Med. 2014 Nov;20(11):1254-62.

28. Chai GS, Duan DX, Ma RH, Shen JY, Li HL, Ma ZW, Luo Y, Wang L, Qi XH, Wang Q, Wang JZ, Wei Z, Mousseau DD, Wang L, Liu G. Humanin attenuates Alzheimer-likecognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull. 2014 Dec;30(6):923-35.

29. Wang JZ, Gao X, Wang ZH. The physiology and pathology of microtubule-associated protein tau. Essays Biochem. 2014;56:111-23.

30. Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, Liu X, Wang Q, Wang P, Wang XC, Wang JZ. Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. J Alzheimers Dis.2014;42(3):1029-39.

31. Zhang Y, Ma RH, Li XC, Zhang JY, Shi HR, Wei W, Luo DJ, Wang Q, Wang JZ, Liu GP. Silencing I2 Rescues Tau Pathologies and Memory Deficitsthrough Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Front Aging Neurosci. 2014 Jun 17;6:123.

32. Lin L, Yang SS, Chu J, Wang L, Ning LN, Zhang T, Jiang Q, Tian Q, Wang JZ. Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41(4):1149-63.

33. Wang JZ, Wang ZH, Tian Q. Tau hyperphosphorylation induces apoptotic escapeand triggers neurodegeneration in Alzheimer's disease. Neurosci Bull. 2014 Apr;30(2):359-66.

34. Liu X, Wang Z, Xia Y, Yu G, Zeng K, Luo H, Hu J, Gong CX, Wang JZ, Zhou XW,Wang XC. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40(2):419-27.

35. Jiang Q, Wang L, Guan Y, Xu H, Niu Y, Han L, Wei YP, Lin L, Chu J, Wang Q,Yang Y, Pei L, Wang JZ, Tian Q. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiol Aging. 2014 Jun;35(6):1352-63.

36. Wang L, Jiang Q, Chu J, Lin L, Li XG, Chai GS, Wang Q, Wang JZ, Tian Q.Expression of Tau40 induces activation of cultured rat microglial cells. PLoS One. 2013 Oct 11;8(10):e76057.

37. Du LL, Xie JZ, Cheng XS, Li XH, Kong FL, Jiang X, Ma ZW, Wang JZ, Chen C, Zhou XW. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr). 2014 Apr;36(2):613-23.

38. Liu GP, Wei W, Zhou X, Shi HR, Liu XH, Chai GS, Yao XQ, Zhang JY, Peng CX, Hu J, Li XC, Wang Q, Wang JZ. Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice. Mol Ther. 2013 Dec;21(12):2247-57.

39. Luo Y, Nie YJ, Shi HR, Ni ZF, Wang Q, Wang JZ, Liu GP. PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta. 2013 May;1833(5):1235-43.

40. Feng Y, Xia Y, Yu G, Shu X, Ge H, Zeng K, Wang J, Wang X. Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2.J Neurochem. 2013 Jul;126(2):234-42.

41. Duan DX, Chai GS, Ni ZF, Hu Y, Luo Y, Cheng XS, Chen NN, Wang JZ, Liu GP. Phosphorylation of Tau by Death-Associated Protein Kinase 1. J Alzheimers Dis. 2013 Jul 23.

42. Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ, Zhu LQ Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3β and Preservation of Postsynaptic Components. J Alzheimers Dis. 2013 Jul 12.

43. Lin L, Huang QX, Yang SS, Chu J, Wang JZ, Tian Q.Melatonin in Alzheimer's disease.Int J Mol Sci. 2013 Jul 12;14(7):14575-93. doi: 10.3390/ijms140714575.

44. Li XH, Du LL, Cheng XS, Jiang X, Zhang Y, Lv BL, Liu R, Wang JZ, Zhou XW. Glycation exacerbates the neuronal toxicity of β-amyloid. Cell Death Dis. 2013 Jun 13;4:e673. doi: 10.1038/cddis.2013.180.

45. Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ, Zhou XW. Nmnat2 attenuates Tau phosphorylation through activation of PP2A. J Alzheimers Dis. 2013 Jan 1;36(1):185-95. doi: 10.3233/JAD-122173.

46. Xiong YS, Wang DL, Tan L, Wang X, Chen LM, Gong CX, Wang JZ, Zhu LQ. Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by pin1 down-regulation. CNS Neurol Disord Drug Targets. 2013 May 1;12(3):436-43.

47. Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, Wang JZ, Wang X . Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging. 2013 Jul;34(7):1748-58. doi: 10.1016/j.neurobiol aging.2012.12.025. Epub 2013 Jan 29.

48. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268translation. Neuron. 2012 Feb 23;73(4):774-88.

49. Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, LiuR, Wang JZ. Synaptic released zinc promotes tauhyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem. 2012 Mar 30;287(14):11174-82. Epub 2012 Feb 10.

50. Li XH, Zhou XW, Wang JZ. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. 2012 Jul;33(7):1400-10

51. Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci. 2011 Jun 8;31(23):8491-501.

52. Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q and Wang JZ. Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2. J Neurosci. 2010, 30:3839-3848.

53. Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, and Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010, 30:3824-3833.

54. Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Yao XQ, Zhang Y, Cao FY, Wang Q, Wang JZ. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. 2010, 20(12):1339-49.

55. Liu YH, Wei W, Yin J, Liu GP, Wang Q, Cao FY, Wang JZ. Proteasome inhibition increases tau accumulation independent of phosphorylation. Neurobiol Aging. 2009 Dec;30(12):1949-61.

56. Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ. Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol. 2009,74(4):1481-1491.

57. Wang JZ, Liu F. Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol. 2008, 85(2):148-175. An invited review.

58. Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging. 2008 Nov;29(11):1654-65.

59. Liu GP, Zhang Y, Yao XQ, Zhang CE, Fang J, Wang Q, Wang JZ. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. 2008 Sep;29(9):1348-58.

60. Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A. 2007, 104(9):3591-3596.

61. Zhu LQ, Wang SH, Yin YY, Liu D, Zheng HY, Shi HR, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007, 27:12211–12220.

62. Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z. Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A. 2006, 103(36):13520-13525.

63. Zhang YJ, Xu YF, Liu YH, Yin J, Li HL, Wang Q and Wang JZ. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB J. 2006, 20(9):1431-1442.

64. Liu SJ, Zhang JY, Li HJ, Fang ZY, Wang Q, Deng HM, Gong C, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem. 2004, 279(48):50078-50088.

65. Hu YY, He SS, Wang XC, Duan QH, Grundke-Iqbal I, Iqbal K, Wang JZ. Level of nonphosphorylated tau in CSF of Alzhemer disease: An Ultrasensitive bienzyme-substrate-recycle ELISA. Am J Pathol. 2002, 160(4): 1269-1278.

66. Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer disease. Nat Med. 1996,2(8): 870-876.

67. Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem. 1995, 270(9):4854-4860.