Academic Degrees

PhD in Pathophysiology, 1991, Tongji Medical University, Wuhan

MS in Pathophysiology, 1987, Tongji Medical University, Wuhan

BS in Clinical Medicine, 1984, Tongji Medical University, Wuhan

Professional Experience

Professor (2000-present), Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology;

Associate Professor (1992-2000), Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology;

Lecturer (1991-1992), Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology

Selected Publications

1. Xiufang Weng, Zhihui Liang, Xiaoling Lu, Maohua Zhong, Shengjun Lu, Caie Zhang, Jing Deng, Xiongwen Wu*, Feili Gong. Peptide-specific, allogeneic T cell response in vitro induced by a self-peptide binding to HLA-A2. Sci China Ser C-Life Sci. 2007, 50:203-211
2. Xiufang Weng, Maohua Zhong, Zhihui Liang, Shengjun Lu, Xueling Chen, Janan Li, Juan Hao, Feili Gong, Xiongwen Wu*. Peptide-dependent inhibition of alloreactive T-cell response by soluble divalent HLA-A2/IgG molecule in vitro. Transplantation. 2007, 84(10):1298-306.
3. Maohua Zhong, Xiufang Weng, Zhihui Liang, Shengjun Lu, Jianan Li, Xueling Chen, Qing Li, Wei Sun, Yinhong Song, Guanxin Shen, Xiongwen Wu*, Dimerization of Soluble HLA-G by IgG-Fc Fragment Augments ILT2-mediated inhibition of T cell alloresponse. Transplantation. 2009 Jan 15;87(1):8-15.
4. Xiufang Weng, Shengjun Lu, Maohua Zhong, Zhihui Liang, Guanxin Shen, Jianguo Chen, Xiongwen Wu*, Allo-restricted CTLs generated by co-culture of PBLs and autologous monocytes loaded with allogeneic peptide/HLA/IgG1-Fc fusion protein. J Leukoc Biol. 2009 Mar;85(3):574-81.
5. Xueling Chen, Yongxiang Yan, Shengjun Lu, Xiufang Weng, Zhihui Liang, Jianan Li, Maohua Zhong, Jie Tang, Wei Xiao, Wei Sun, Guanxin Shen, Xiongwen Wu*, Raising allo-restricted CTLs by co-culture of murine splenocytes with autologous macrophage bearing the peptide/allo-MHC complex. Hum Immunol. 2009 Feb;70(2):79-84.
6. Li J, Weng X, Liang Z, Zhong M, Chen X, Lu S, Sun W, Song Y, Wu X, Shen G.. Viral specific cytotoxic T cells inhibit the growth of TfR-expressing tumor cells with antibody targeted viral peptide/HLA-A2 complex. Cell Immunol. 2010;263(2):154-60.
7. Wang G, Hu P, Yang J, Shen G, Wu X. The effects of PDL-Ig on collagen-induced arthritis. Rheumatol Int. 2011 Apr;31(4):513-9.
8. Song Y, Sun W, Weng X, Liang Z, Yu Q, Wang Z, Ouyang L, Chen J, Wu X, Shen G, Wu X*. Tumor rejection effects of allo-restricted tumor peptide-specific CD4+ T cells on human cervical cancer cell xenograft in nude mice. Cell Transplantation. 21(7):1503–1514, 2012.
9. Gong Y, Wang Z, Liang Z, Duan H, Ouyang L, Yu Q, Xu Z, Shen G, Weng X*, Wu X*. Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells. PLoS One. 7(10):e47435, 2012.
10. Yu Q, Zhang L, Ouyang L, Gong Y, Liang Z, Shen G, Weng X*, Wu X*. A similarity in peptide cross-reactivity between alloantigen- and nominal antigen-induced CD8(+) T cell responses in vitro. Immunogenetics. 65(3):173-84, 2013.
11. Ouyang L, Li X, Liang Z, Yang D, Gong F, Shen G, Weng X, Wu X. CD8low T-cell subpopulation is increased in patients with chronic hepatitis B virus infection. Mol Immunol. 2013 Dec;56(4):698-704.
12. Wang Z, Ouyang L, Liang Z, Chen J, Yu Q, Jeza VT, Gong Y, Shen G, Weng X, Wu X. CD8lowCD28- T Cells: A Human CD8 T-Suppressor Subpopulation With Alloantigen Specificity Induced by Soluble HLA-A2 Dimer In Vitro. Cell Transplant. 2015;24(10):2129-42.
13. 1Luo Y, Zhou Y, Xiao W, Liang Z, Dai J, Weng X, Wu X Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response. Brain Res. 2015 Feb 9;1597:86-94.

Courses Taught

1001112 Immune biology (undergraduate)

1001111 Medical Immunology (undergraduate)

1001113 Medical Immunology (undergraduate)

1003631 Medical Immunology (undergraduate)

1003632 Medical Immunology (undergraduate)

1409271 Tropical Medicine (undergraduate)

510.512 Basic Immunology(graduate)

510.534 Molecular Immunology(graduate)

510.523 Experimental Immunology (graduate)

510.814 Proceedings of Immunology (graduate)

Project

1. Enhancing the regulatory capacity of iNKT cells through manipulating cellular metabolism by targeting mTOR/AMPK pathway. National Natural Science Foundation of China (31570913), 2016-2019

2. Clone and characterize the single-epitope specific T-cell receptor from human T-cell repertoire. China Postdoctoral Science Foundation (200902431), 2010-2013

3. Soluble divalent pMHC complexes protect mice from EAE by inducing autoreactive T-cell anergy. National Natural Science Foundation of China (30801017), 2009-2012