Academic Degrees

PhD in Pharmacology, 1988, Heidelberg University, Germany

MS in Pharmacology, 1981, Wuhan medical college, China

BS in Clinical Medicine, 1978, Wuhan medical college, China

Professional Experience

Professor (1992-present), Huazhong University of Science and Technology, School of Basic Medicine, Department of Pharmacology

Lecturer (1988-1992), Tongji medical university, School of Basic Medicine, Department of Pharmacology

Selected Publications

1. KuihaoChen, XiaohuiXu, HaiyingSun, XinlingDu, Hui Liu, Lei Yang, GuoshengXiao, Yan Wang, ManwenJin*, GuirongLi*.Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes, Heart Rhythm, 2016, 13(3): 762-770
2. KuihaoChen, Hui Liu, Lei Yang, ManwenJin*, GuirongLi*.SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes, Pflugers Arch, 2015, 467(6): 1227-1236
3. KuihaoChen, XiaohuiXu, Yi Liu, Yan Hu, ManwenJin*, GuirongLi*. TRPM7 channels regulate proliferation and adipogenesis in 3T3-L1 preadipocytes, J Cell Physiol, 2014, 29(1): 60-67
4. Xin Xin, XianhuiLi, JianzhaoWu, KuihaoChen, Yi Liu, ChunjieNie, Yan Hu, ManwenJin*.Pentamethylquercetin ameliorates fibrosis in diabetic Goto-Kakizaki rat kidneys and mesangial cells with suppression of TGF-β/Smads signaling, Eur J Pharmacol, 2013, 713(1-3): 6-15
5. XiaohuiXu #, HaiyingSun #, YanhuiZhang, Wei Wu, KuhaoChen, Yi Liu, ChunyuDeng, XiyongYu, ManwenJin*, Li GR*.Allitridi inhibits multiple cardiac potassium channels expressed in HEK 293 cells, PLoS One, 2012, 7(12): e51550
6. XianhuiLi, Xin Xin, Yan Wang, JianzhaoWu, zhendongJin, Lina Ma, ChunjieNie, Xiao Xiao, Yan Hu, ManwenJin*,Pentamethylquercetin Protects Against Diabetes-Related Cognitive Deficits in Diabetic Goto-Kakizaki Rats.J Alzheimers Dis, 2013, 34(3): 755-767
7. Yi Liu, XiaohuiXu, Zheng Liu, XinlingDu, KuihaoChen, Xin Xin, ZhendongJin, JizhongShen, Yan Hu, GuirongLi, ManwenJin*, Effects of the natural flavone trimethylapigenin on cardiac potassium currents.BiochemPharmacol, 2012, 84(4): 498-506
8. JizhongShen, Lina Ma, Yi Han, JianxiongLiu, WeiqinYang, Lei Chen, Yi Liu, Yan Hu, ManwenJin*, Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.Diabetologia, 2012, 55(6): 1836-1846
9. Ting He, Lei Chen, Yong Chen, Yi Han, WeiqinYang, ManwenJin*, In Vivo and In Vitro Protective Effects of Pentamethylquercetin on Cardiac Hypertrophy.Cardiovasc Drugs Ther, 2012, 26(2): 109-120
10. XiaohuaZhang, YingyingZhang, HaiyingSun, ManwenJin*, GuirongLi*, Functional ion channels and cell proliferation in 3T3-L1 preadipocytes.J Cell Physiol, 2012, 227(5): 1972–1979
11. LeiChen, Ting He, Yi Han, JizhongSheng, Si Jin, ManwenJin*, Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6.Molecules, 2011, 16(7): 5754-5768
12. XiaohuaZhang, ManwenJin*, HaiyingSun, ShetuanZhang, GuirongLi*,The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells.Br J Pharmacol, 2010, 161(4): 872-884
13. Yi Han, JiadaoChen, ZumeiLiu, Yuan Zhou, JiahongXia, XinlingDu, ManwenJin*, Functional ion channels in mouse cardiac c-kit+ cells.Am J Physiol Cell Physiol, 2010, 298(5): 1109-1117
14. Li GR, Wang HB, Qin GW, Jin MW, Tang Q, Sun HY, Du XL, Deng XL, Zhang XH, Chen JB, Chen L, Xu XH, Cheng LC, Chiu SW, Tse HF, Vanhoutte PM, Lau CP.Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs.Circulation. 2008, 13;117(19):2449-57.

Awards and Honors

1. Variation of fat plasticity in animals with obesity and type 2diabetes and mechanisms of pentamethylquercetin for browning white adipocytes. National Natural Science Foundation of China, 2013- 2016
2. Effects and mechanisms of pentamethylquercetin for ameliorating metabolic syndrome. National Natural Science Foundation of China, 2008- 2010
3. Cardiac Membrane receptor of steroid hormone and its nongenomic effects. National Natural Science Foundation of China, 2003- 2005
4. Action of endothelin and its relationship with potassium channels. National Natural Science Foundation of China,1991-1993
5. Research on human endothelium-derived contracting factor. National Natural Science Foundation of China,1989-1992

Courses Taught

1001051Pharmacology (undergraduate)

510.507Preclinical and clinical evaluation for new drug (graduate)

510.533Cardiovascular pharmacology (graduate)