Academic Degrees

Ph.D in Pharmacology, 2007, Tongji Medical College of Huazhong University of Science & Technology.

M.Sc. in Pharmacology, 2002, Tongji Medical College of Huazhong University of Science & Technology.

B.Sc. in Pharmacy, 1999, Tongji Medical University.

Professional Experience

Associate Professor and Professor (2014-present), Huazhong University of Science and Technology, Department of Pharmacology;

Visiting Associate Professor (2012-2013), Yale Medical School, Programme of Comparative Medicine;

Lecturer and Associate Professor (2005-2011), Huazhong University of Science and Technology, Department of Pharmacology.

Assistant Professor (2002-2004) , Huazhong University of Science and Technology, Department of Pharmacology.

Selected Publications

1. Long L, Toda C, Jeong JK, Horvath TL, Diano S. PPAR_γ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding. J Clin Invest. 2014 Sep;124(9):4017-27.
2. Yang S, Long LH, Li D, Zhang JK, Jin S, Wang F, Chen JG. β-Guanadinopropionic Acid Extends the Lifespan of Drosophila Melanogaster via an AMPK-dependent Increase in Autophagy. Aging cell. 2015 Dec;14(6):1024-33.
3. Yu DF, Shen ZC, Wu PF, Guan XL, Chen T, Jin Y, Hu ZL, Ni L, Wang F, Chen JG, Long LH*. HFS-Triggered AMPK Activation Phosphorylates GSK 3β and Induces E-LTP in Rat Hippocampus In Vivo. CNS Neurosci Ther. 2016 Jun;22(6):525-31.
4. Chen T, Yang YJ, Li YK, Liu J, Wu PF, Wang F, Chen JG, Long LH*. Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo. J Ethnopharmacol. 2016 Jun 5:74-82
5. Zhang JQ, Wu PF, Long LH, Chen Y, Hu ZL, Ni L, Wang F, Chen JG. Resveratrol promotes cellular glucose utilization in primary cultured cortical neurons via calcium-dependent signaling pathway. J Nutr Biochem. 2013 , 24(4):629-37.
6. Long LH, Wu PF, Guan XL, Zhang JQ, Jin Y, Zhang Z, Wang Y, Li YY, Chen JG, Wang F. Determination of Protein-bound Methionine Oxidation in the Hippocampus of Adult and Old Rats by LC-ESI-ITMS Method after Microwave-assisted Proteolysis. Anal Bioanal Chem. 2011 Feb;399(6):2267-74.
7. Yang YJ, Wu PF, Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F, Chen JG. Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. Aging Cell. 2010 Oct;9(5):709-21.
8. Ma J, Long LH, Hu ZL, Zhang H, Han J, Ni L, Wang F, Chen JG, Wu PF. Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain Res. 2015 Jul 30;1615:71-9.
9. Chen Y, Zhou J, Xie N, Huang C, Zhang JQ, Hu ZL, Ni L, Jin Y, Wang F, Chen JG, Long LH*. Lowering glucose level elevates [Ca²⁺]_i in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca²⁺ channel activation and GSK3β inhibition. Acta Pharmacol Sin. 2012，33(5):594-605.
10. Long LH, Wu PF, Chen XL, Zhang Z, Chen Y, Li YY, Jin Y, Chen JG, Wang F. HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats. Acta Pharmacol Sin. 2010 Nov;31(11):1508-14.
11. Long L, Liu J, Liu R, Wang F, Hu Z, Xie N, Fu H, Chen J.Differential Effects of Methionine and Cysteine Oxidation on [Ca²⁺]_i in Cultured Hippocampal Neurons. Cellular Molecular Neurobiology. 2009，29(1):7-15
12. Long LH, Liu RL, Wang F, Liu J, Hu ZL, Xie N, Jin Y, Fu H, Chen JG. Age-related synaptic changes in the CA1 stratum radiatum and spatial learning impairment in rats. Clin Exp Pharmacol Physiol. 2009 Jul;36(7):675-81.

Awards and Honors

1. The antidepressive effect of prolyl carboxypeptidase, which is the hydrolase of of melanocyte-stimulating hormone. National Natural Science Foundation of China, 2017-2019

2. Dopamine receptor in hypothalamic neurons works as target for therapy of metabolic imbalance. Independent Innovation Foundation of Huazhong University of Science and Technology, 2014-2015

3. The novel target of maitaining energy homeostasis-the effect of AMPK signaling pathway on ion channels in hypothalamic neurons. National Natural Science Foundation of China, 2009-2011

4. The role of Protein Interacting with C Kinase – 1 in the regulation of AMPA receptor traficking by amyloid beta, Natural Science Foundation of Hubei Province, 2008-2010

Courses Taught

1001051 Pharmacology (undergraduate)

1412061 Cosmeceuticals for skin protection(undergraduate)

1411342 Proper lifestyle against modern disease & subhealth (undergraduate)

1411892 Rational drug use (undergraduate)

510.507 Preclinical and clinical evaluation for new drugs (graduate)

510.544 Advanced pharmacology (graduate)