Academic Degrees

1974-1977: study in department of clinical medicine, Wuhan Medical College

1978-1980: study in department of clinical medicine, Wuhan Medical College

1985-1988: study in the school for postgraduates, Tongji Medical College

Professional Experience

1990-1993: study in department of pharmacology and toxicology, University of Innsbruck, Austria

2002.04-2002.10: study in Ludwig Maximilians Universität München, Germany

2006.08-2006.11: study in Johannes Gutenberg-Universität Mainz, Germany

2009.2 -2009.2 ：Heiderberg University,Germany

2011.12.1-2011.12.10 Johannes Gutenberg-Universität Mainz, Germany

Selected Publications

1. Yun Lu, Chang-jun Li, Cheng Chen, Pan Luo, Mei Zhou, Cai Li, Xu-lin Xu ,Qing Lu, Zhi He, Lian-jun Guo.Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels.Neuropharmacology 110 (2016) 308e321. (IF:5.127)
2. Pan Luo , Cheng Chen , Yun Lu, TianLi Fu, Qing Lu, Xulin Xu , Changjun Li ,Zhi He, Lianjun Guo.Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats. Behavioural Brain Research.2016,308:6.13 (IF:3.0)

3. Pan Luo , Xiaoxue Zhang, Yun Lu, Cheng Chen, Changjun Li , Mei Zhou, Qing Lua, Xulin Xu,Guanxin Shen, Lianjun Guo. Fluoxetine ameliorates cognitive impairments induced by chronic cerebral hypoperfusion via down-regulation of HCN2 surface expression in the hippocampal CA1 area in rats. Pharmacology, Biochemistry and Behavior 132 (2015) 96–102 (IF:2.781)

4. Li Liu, Chang-jun Li, Yun Lu, Xian-gang Zong, Chao Luo, Jun Sun& Lian-jun Guo.Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Scientific Reports | 5:14474 | DOI: 10.1038/srep14474 (IF:5.02)

5. Pan Luo，Yun Lu，Changjun Li，Mei Zhou，Cheng Chen，Qing Lu，Xulin Xu，Zhi He，Lianjun Guo.Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1region.J.Neurobiology of Learning and Memory.2015,123:72-83 ( IF:3.652)

6.Yun Lu, Changjun Li , Mei Zhou, Pan Luo, Pengcheng Huang, Jiahong Tan, Qing Lu, Xulin Xu,Zhi He , Lianjun Guo.Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats. Pharmacology, Biochemistry and Behavior 132 (2015) 96–102 ( IF:2.781)

7.Mei Zhou, Pan Luo, Yun Lu , Chang-jun Li, Dian-shiWang , Qing Lu, Xu-lin Xu,Zhi He, Lian-jun Guo Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Progress in Neuro-Psychopharmacology & Biological Psychiatry 56 (2015) 207–214 ( IF:4.025)

8.Pan Luo and Lianjun.HCN Channels: From the Role in Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments to a New Therapeutic Target for Vascular Dementia. Neurology & Neurophysiology 2015.6（4）：1-6

9.. Chang-jun Li • Yun Lu • Mei Zhou ,Lian-jun Guo.Electrophysiological properties of hippocampal–cortical neural networks, role in the processes of learning and memory in rats. J Neural Transm.DOI 10.1007/s00702-014-1164-8

10.Chang-jun Li • Mei Zhou • Hui-ge Li ,Qing Lv • Xu-lin Xu • Lian-jun Guo.Clonidine Suppresses the Induction of Long-Term Potentiation by Inhibiting HCN Channels at the Schaffer Collateral–CA1 Synapse in Anesthetized Adult Rats. Cell Mol Neurobiol (2013) 33:1075–1086

11. Jie Ding • Gang Fu • Yan Zhao • Zhenyong Cheng，Yang Chen • Bo Zhao • Wei He • Lian-Jun Guo. EGCG Ameliorates the Suppression of Long-Term Potentiation Induced by Ischemia at the Schaffer Collateral-CA1 Synapse in the Rat. Cell Mol Neurobiol (2012) 32:267–277

12. Zhao, B.; Chen, Y.; Sun, X.; Zhou, M.; Ding, J.; Zhan, J.-J.; Guo, L.-J. Phenolic Alkaloids from Menispermum dauricum Rhizome Protect against Brain Ischemia Injury via Regulation of GLT-1, EAAC1 and ROS Generation. Molecules 2012, 17, 2725-2737.

13. Yang Chen, Bo Zhao, Xiaolan Huang, Jinjin Zhan, Yan Zhao, Mei Zhou, Lianjun Guo.

Purification and neuroprotective effects of polysaccharides from Opuntia Milpa Alta

incultured cortical neurons International Journal of Biological Macromolecules 2011（49）

681-687

14. Zhenyong Cheng, Wei He, Xiaoxia Zhou, Qing Lv , Xulin Xu , Shanshan Yang ,

Chenming Zhao , Lianjun Guo. Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro European Journal of Pharmacology 2011(664) 20-28

15.Qin Li , Yuhua Chen, Li Sun, Gang Fu , Lianjun Guo. Vasodilatation produced by Fasudil

Mesylate in vivo and in vitro. Vascular Pharmacology2011(55) 121-126

16. Qin Li. Dong Liu. Xianju Huang,Lianjun Guo.Fasudil Mesylate Protects PC12 Cells from Oxidative Stress Injury via the Bax-Mediated Pathway. Cell Mol Neurobiol (2011) 31:243–250

17. Li S., He Z., Guo L*., Huang L., Wang J., He W. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal CA1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience (2010) 165: 654-661

18. He Wei, Cheng Zhenyong, Fu gang, Xu Xulin, Lu Qing, Guo Lianjun*. ZD7288-induced suppression of long-term potentiation was attenuated by exogenous NMDA at the Schaffer collateral-CA1 synapse in the rat in vivo. European Journal of Pharmacology, DOI information: 10.1016/j.ejphar.2009.12.038

19. Huang Xianju, Li Qin, Li Huige, Guo Lianjun*. Neuroprotective and Antioxidative Effect of Cactus Polysaccharides In Vivo and In Vitro. Cell Mol Neurobiol (2009) 29:1211–1221

20.Li Qin, Huang Xian-Ju, He Wei, Ding Jie, Jia Jun-Ting, Fu Gang, Lian-Jun Guo*. Neuroprotective Potential of Fasudil Mesylate in Brain Ischemia-Reperfusion Injury of Rats. Cell Mol Neurobiol (2009) 29:169–180

21.Lu Qing, Xu Xu-Lin, He Zhi, Huang Xian-Ju, Guo Lian-Jun*, Wang Hong-Xing. Guattegaumerine Protects Primary Cultured Cortical Neurons Against Oxidative Stress Injury Induced by Hydrogen Peroxide Concomitant with Serum Deprivation. Cell Mol Neurobiol (2009) 29:355–364

22.Huang Lin, Li Qin, Li Huige, He Zhi, Cheng Zhenyong, Chen Jianguo, Guo Lianjun*. Inhibition of intracellular Ca²⁺ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons. European Journal of Pharmacology 602 (2009) 238–244

23.He Zhi, Lu Qing, Xu Xulin, Huang Lin, Chen Jianguo, Guo Lianjun*. DDPH ameliorated oxygen and glucose deprivation-induced injury in rat hippocampal neurons via interrupting Ca²⁺ overload and glutamate release. European Journal of Pharmacology 603 (2009) 50–55

24.Huang Lin, He Zhi, Guo Lianjun*, Wang Hongxing. Improvement of Cognitive Deficit and Neuronal Damage in Rats with Chronic Cerebral Ischemia via Relative Long-term Inhibition of Rho-kinase. Cell Mol Neurobiol (2008) 28:757–768

25.He Zhi, Liao Yun, Zheng Min, Zeng Fan-Dian, Guo Lian-Jun*. Piracetam Improves Cognitive Deficits Caused by Chronic Cerebral Hypoperfusion in Rats. Cell Mol Neurobiol (2008) 28:613–627

26.He Zhi, Huang Lin, Wu Yan, Wang Jianzhi, Wang Hongxing, Guo Lianjun*. DDPH: Improving cognitive deficits beyond its α₁-adrenoceptor antagonism in chronic cerebral hypoperfused rat. European Journal of Pharmacology 588 (2008) 178–188

27.Huang X.J., Li.Q, Guo L.J.* et al. Protection of cactus polysaccharide against H₂O₂–induced damage in the rat cerebral cortex and hippocampus differences in time of administrational (J). Neural Regenration Research, 2008, 3(1):14-18

28.Ouyang Changhan, Guo Lianjun*, Lu Qing, Xu Xulin, Wang Hongxing. Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum Neuroscience Letters 420 (2007) 174–178

Awards and Honors

1. The characters of amino acids neurotransmitter release in hypothalamus. Science and technology progress third prize of National Ministry of Health 1999, No.1, certificate number: 99-III-47-1, awards department: China National Ministry of Health, awards time: 1999, ranking of the winners: Lianjun Guo, Jizhou Xiang, Ling Qu, Bei Cheng.
2. The release characters of neuropeptide Y (NPY) and the drug modulation of neuropeptide Y (NPY) on ischemic myocardium. Science and technology progress third prize of Hubei Province Scientific Agency 2000, No.2
3. The release characters of neuropeptide Y (NPY) and the drug modulation of neuropeptide Y (NPY) on ischemic myocardium. Science and technology progress achievements third prize of Wuhan. 2000, No.2
4. The research on practical ability training model of medical students. National teaching innovation achievements second prize 2005, No.4
5. The experiment of efferent nerve drugs. Chinese Medical Association national teaching technical excellence in teaching third prize 2005, No.1

Project

1．Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN2 in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion National Natural Science Foundation of China 2012.1-2015.12, Batch number: (No.81173038), person in charge

2.Modulation of hippocampal Ih channels on the NMDA receptor subtypes functional recombination in the condition of brain ischemia. National Natural Science Foundation of China 2008-2010, Batch number: (No. 30772559), person in charge

3.The effects of hippocampal HCN1 channels changes on glutamate release in brain ischemic condition (finished). National Natural Science Foundation of China 2004-2006, Batch number: （No. 30371639） person in charge

1. Research on the cross talk of between excitatory amino acids and inhibitory amino acids in the condition of brain ischemia (finished). National Natural Science Foundation of China 2002-2004, Batch number: 30171082, person in charge
2. Research on the stunning phenomenon and the mechanism underlying of neurocytes in reperfusion after short term ischemia. National Natural Science Foundation of China 2001-2003, Batch number: 30070825/C030313, the second person in charge
3. Modulation of GABA receptor subtypes on cerebral vessels in brain ischemic condition. National Natural Science Foundation of China 1995-1997（No. 39470811）, person in charge.
4. The release characters of neuropeptide Y (NPY) and the drug modulation of neuropeptide Y (NPY) on ischemic myocardium. National Natural Science Foundation of China 1991-1993, second person in charge.
5. Modulation of GABA receptors on the function of periphery cardiovascular system. China National Board of Education 1993-1995, person in charge.
6. The modulation of GABA receptor subtypes on angiosthenia. China National Ministry of Health 1993-1995, person in charge.
7. The modulation of GABA receptor subtypes on the function of cardiovascular system. Natural Science Foundation of Hubei Province 1994-1996, person in charge.
8. Research of pharmacological function of Wekexing on peptic ulcer. Scientific and techonological research topics of Hubei Province 2003-2005, person in charge.
9. The research of protective mechanism of epistom’s anti-ischemic function on brain ischemia. Shanghai Institute of Pharmaceutical Industry 2004-, person incharge.
10. The research of Fasudil Mesylate’s expansion function on cerebral vessels. Wuhan Pharmaceutical Co., Ltd 2004-2005, person in charge.
11. The research on pharmacology and toxicology of Freeze-dried powder of toad venom. Hainan Pharmaceutical Co., Ltd 2005-2006, person in charge.
12. The scientific research cultural model of seven years medical students. Teaching innovation topics of Hubei Province 2002-2004, person in charge.
13. Pharmacological experiment CI courseware of efferent nerve drugs. National Ministry of Health 2001-2002, person in charge.