Academic Degrees

PhD in Pathophysiology,2007, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

MD in Clinical Medicine, 2002, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Professional Experience

Professor (2012-present), Tongji Medical College, Huazhong University of Science and Technology, Department of Pathophysiology

Postdoc. (2009-2010), School of Medicine,Yale University

Associate Professor (2008-2012), Tongji Medical College, Huazhong University of Science and Technology, Department of Pathophysiology

Lecturer (2007-2008), Tongji Medical College, Huazhong University of Science and Technology, Department of Pathophysiology

Selected Publications

1. Shu S, Zhu H, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ*, Lu Y*.Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1.J Neurosci. 2016 Oct 19;36(42):10843-10852.

2. An TH^#, He QW^#, Xia YP^#, Chen SC, Baral S, Mao L, Jin HJ, Li YN, Wang MD, Chen JG, Zhu LQ*, Hu B*.MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1.Mol Neurobiol. 2016 Oct 8.

3. Yang X^#, Yao C^#, Tian T^#, Li X^#, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ*, Lu Y*.A novel mechanism of memory loss in Alzheimer's disease mice via the degeneration of entorhinal-CA1 synapses.Mol Psychiatry. 2016 Sep 27.

4. Xie AJ, Liu EJ, Huang HZ, Hu Y, Li K, Lu Y, Wang JZ*, Zhu LQ*. Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes. Mol Neurobiol. 2016 Sep;53(7):4992-9.

5. Liu YS^#, Dai X^#, Wu W^#, Yuan FF, Gu X, Chen JG, Zhu LQ*, Wu J*. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis.Mol Neurobiol. 2016 Mar 3.

6. Wang MD^#, Wang Y^#, Xia YP^#, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, Tu Y, He QW, Zhang GP, Wang L, Xu GZ, Xu HB, Zhu LQ*, Hu B*. High Serum MiR-130a Levels Are Associated with Severe Perihematomal Edema and Predict Adverse Outcome in Acute ICH.Mol Neurobiol. 2016 Mar;53(2):1310-21.

7. Li K, Liu FF, He CX, Huang HZ, Xie AJ, Hu F, Liu D, Wang JZ*, Zhu LQ*. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol. 2016 Jan;53(1):391-401.

8. Xiong YS^#, Liu FF^#, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ*, Zhu LQ*. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. Aging Cell. 2015 Oct;14(5):867-77.

9. Hu J, Huang HZ, Wang X, Xie AJ, Wang X, Liu D, Wang JZ*, Zhu LQ*. Glycogen synthase kinase-3 links the olfactory deficit to hippocampal impairments. Mol Neurobiol. 2015 Dec;52(3):1601-17.

10. Liu DY, Shen XM, Yuan FF, Guo OY, Zhong Y, Chen JG, Zhu LQ*, Wu J*. The physiology of BDNF and its relationship with ADHD. Mol Neurobiol. 2015 Dec;52(3):1467-76.

11. Liu D, Wei N, Man HY, Lu Y*, Zhu LQ*, Wang JZ*. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ. 2015 Apr;22(4):583-96.

12. Pei L, Shang Y, Jin H, Wang S, Wei N, Yan H, Wu Y, Yao C, Wang X, Zhu LQ*, Lu Y*. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. J Neurosci. 2014 May 7;34(19):6546-56.

13. Chen Y^#, Wang B^#, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci. 2014 Feb 12;34(7):2464-70.

14. Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D*, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014 Jan;76 Pt A:80-7.

15. Tang H^#, Shen N^#, Jin H^#, Liu D*, Miao X*, Zhu LQ*. GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis. Mol Neurobiol. 2013 Dec;48(3):404-11.

16. Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ*, Zhu LQ*. Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3β and Preservation of Postsynaptic Components. J Alzheimers Dis. 2013, 37(3):515-527.

17. Xiong YS, Wang DL, Tan L, Wang X, Chen LM, Gong CX, Wang JZ*, Zhu LQ*. Inhibiton of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 downregulation. CNS & Neurological Disorders - Drug Targets. 2013, 12(3):436-443.

18. Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ*, Zhu LQ*. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of b-amyloid. Neuropathology and Applied Neurobiology. 2013 Oct;39(6):612-22.

19. Peng CX^#, Hu J^#, Liu D, Hong XP, Wu YY, Zhu LQ*, Wang JZ*. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging. 2013 Jun;34(6):1555-63.

20. Zhao K, Wen R, Wang X, Pei L, Yang Y, Shang Y, Bazan N, Zhu LQ*, Tian Q*, Lu Y*. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability.J Neurosci. 2013 May 15;33(20):8861-5.

21. Zhong R, Yang B, Tang H, Zou L, Song R, Zhu LQ*, Miao XP*.Meta-analysis of the association between DCDC2 polymorphisms and risk of Dyslexia.Mol Neurobiol. 2013 Feb;47(1):435-42.

22. Wang X^#, Wang ZH^#, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway. Mol Neurobiol. 2013 Feb;47(1):373-81.

23. Wang SH^#, Liao XM^#, Liu D, Hu J, Yin YY, Wang JZ*, Zhu LQ*. NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012 Nov;63(6):1085-92.

24. Wu J, Xiao H, Sun H, Zou L, Zhu LQ. Role of dopamine receprots in ADHD: a systematic meta-analysis.Mol Neurobiol. 2012 Jun;45(3):605-20.

25. Yang Y^#, Shu X^#, Liu D^#, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron. 2012 Feb 23;73(4):774-88.

26. Liao K, Liu D, Zhu LQ. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex.Neurosci Lett. 2012 Jan 17;507(1):22-6.

27. Hu J, Wang X, Liu D, Wang Q, Zhu LQ. Olfactory deficits induce neurofilament hyperphosphorylation.Neurosci Lett. 2012 Jan 11;506(2):180-3.

28. Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ*, Zhu LQ*. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012 Jan;120(1):157-64.

29. Zhou P, Chen Z, Zhao N, Liu D, Hu J, Guo ZY, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-Carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities.Rejuvenation Res. 2011 Dec;14(6):669-79.

30. Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ. Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C.J Neurochem. 2011 Sep;118(5):864-78.

31. Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN. 2010 Sep;46(8):702-7.

32.Zhu LQ^#, Liu D^#, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010 Mar 10;30(10):3624-33.

33.Zhu LQ^#, Zheng HY^#, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010 Mar 10;30(10):3839-48.

34. Yin YY, Liu H, Liu Z, Cong XB, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimer’s Disease 2010;19(2):735-46.

35. Liu XA, Zhu LQ*, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ*. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem Res. 2008 Sep;33(9):1811-20.

36. Shi HR, Zhu LQ*, Wang SH, Liu XA, Tian Q, Zhang Q, Wang Q, Wang JZ*. 17 β-estradiol attnuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner.J Neural Transm (Vienna). 2008 Jun;115(6):879-88.

37. Zhu LQ^#, Wang SH^#, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007 Nov 7;27(45):12211-20.

38. Wang SH^#, Zhu LQ^#, Shi H, Zheng H, Tian Q, Wang Q, Liu R, Wang JZ.Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.Neurochem Res. 2007 Aug;32(8):1329-35.

39. Zhu LQ, Wang SH, Ling ZQ, Wang DL, Wang JZ.Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat.J Pineal Res. 2004 Sep;37(2):71-7.

Courses Taught

1001001Pathophysiology (undergraduate)

510.526Clinic Pathophysiology (graduate)

510.536The newest technologies and methods in neuroscience (graduate)

510.807Advanced Pathophysiology(Ph.D)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease(Ph.D)

Project

1.Role of long non-coding RNA mSYT-AS disorder in the dysfunction ofECIIPN-CA1PV neural circuit in Alzheimer's disease. Training Program of the Major Research plan of the National Natural Science Foundation of China (Grant No.91632114), 2017-2019

2. Academic Frontier Youth Team of Huazhong University of Science and Technology, 2016-2020

3. Top-Notch Young Talents Program of China in 2014, 2015-2017

4. Role of AK036689 (a long non-coding RNAs) in the dysfunction ofhippocampal neural circuits in the early stage of Alzheimer's disease. The National Natural Science Foundation of China (Grant No.31571039), 2016-2019

5. The role of the mental retardation protein KIAA2022 on neuronmorphogenesis and synapse formation. The Joint Research Fund of the National Natural Science Foundation of China (Grant No.81428009), 2015-2016

6. HDAC2 regulates the production of Abeta and tauopathy and the underlying mechanisms. The Science Found for Distinguished Young Scholars of Hubei Province (Grant No. 2014CFA017), 2014-2016

7. In vivo study of the EPAC/miR-124 signalling pathway in late-onset Alzheimer’s disease. The Joint Research Fund of NSFC of China and FRQS of Canada (Grant No. 81361120245), 2013-2015

8. Explore the possible role of GSK-3 in brain function and neurological disease by novel genetic approaches. The SpecialJoint Research Foundation of Ministry of Science and Technology of China and Canada (Grant No. 2011DFG33250), 2012-2015

9. Effect of olfactory dysfunction in entorhinal-hippocampus circuits and their roles in Alzheimer’s disease. Training Program of the Major Research plan of the National Natural Science Foundation of China (Grant No.91132725), 2012-2014

10. Role of EphB2 signal in tau pathology in Alzheimer's disease. Alzheimer’s Association New Investigator Initiate Grant (Grant No.NIRG-11-205737), 2011-2013

11. The dysfunction of PSA-NCAM in Alzheimer’s disease and the underlying mechanisms. The New-Century Supporting Program for Outstanding Talents from the Ministry of Education of China (Grant No.NCET-10-0421), 2011-2014

12. Role of ERbeta in Age associated memory impairment and the underlying mechanism. The National Natural Science Foundation of China (Grant No.30971478), 2010-2012

13. Role of GSK-3 in AD-like synaptic disorder and the underlying mechanism. The National Science Foundation for Young Scientists of China (Grant No.30800342), 2009-2011