Academic Degrees

PhD in Developmental Biology, 2011,Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

BS in Biology, 2004, Minzu University

Professional Experience

Professor (2016-present), Huazhong University of Science and Technology, Department of Medical Genetics;

Post doctor (2011-2016), Columbia University Medical Center, Benjamin Ohlstein lab.

Selected Publications

1. Guo, Z, Lucchetta E, Rafel N and Ohlstein B (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development 40:81-86

2. Guo, Z. and Ohlstein B. (2015). Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science 20 November 2015:350(6263)

3. Guo Z, Driver I, Ohlstein B. (2013). Injury induced BMP signaling negatively regulates Drosophila midgut homeostasis. Journal of Cell Biology 201 (6)945-961

4. Guo, Z. and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development 136, 3627-35

5. Li, C. Y., Guo, Z. and Wang, Z. (2007). TGFβ receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis. DevBiol 309, 70-7.

Courses Taught

1001101Cell Biology (undergraduate)

1001121 Medical Genetics (graduate)

510.543 Advances in Medical Genetics (graduate)

510.805 Advanced Medical Genetics (Ph.D)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (Ph.D)

Project

1. Determine the mechanism of the“differentiation toggle” in Drosophila ISCs.

2. Determine the mechanism of high-low Notch signaling establishment.

3. Determine if mammalian intestinal stem cells use the same bidirectional Notch signaling toregulate multipotency.