Academic Degrees

1987/09-1990/07 MSc inPharmacology, China Pharmaceutical University, Nanjing, China

1996/01-1998/07 PhD in Neuroscience, University of Toronto, Toronto, Canada

1998/07-2000/07 Neuroscience, Columbia University, New York

Professional Experience

2000/07-2004/05 Assistant Professor, Neuroscience, University of Calgary

2008/05-2011/05 Bollinger Endowed Professor, Louisiana State University School of Medicine, Health Science Center, New Orleans

2011/05- National Endowed Professor, Huazhong University of Science and Technology

Selected Publications

Selected publications (10 of 98)

1. Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y(2017) Treatment of Alzheimer’s disease by activation of cholinergic synapses in the hippocampus. Nature Communications (in press)

2. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y (2016). A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal-CA1 synapses. Molecular Psychiatry 10.1038mp.

3. Yang Y., Shu X., Liu D., Shang Y., Wu Y., Pei L., Xu X., Tian Q., Zhang J., Qian K., Wang Y.X., Petralia R.S., Tu W., Zhu L.Q., Wang J.Z., Lu Y (2012) EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron 73, 77-788.

4. Tu, W., Xu, X., Peng, L., Zhong X., Zhang, W., Soundarapandian, M.M., Belal, C., Wang, M., Jia, N., Lew, F., Chan, S.L., Chen, Y., and Lu, Y. (2010). DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell 141, 28-46.

5. Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH (2008) Deregulation of HDAC1 by p25/cdk5 in neurotoxicity. Neuron 60: 803-817

6. Peng, P.L., Zhong, X.F., Tu, W.H., Soundarapandian, M.M., Molner, P., Zhu, D.Y., Liu, S.H., and Lu, Y. (2006). ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia. Neuron 49, 719-733.

7. Liu, S.H., Lau, L., Wei, J.S., Zhu, D.Y., Zou, S., Sun, H.S., Fu, Y.P., Liu, F., and Lu, Y. (2004). Expression of Ca²⁺-permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia. Neuron 43, 43-55.

8. Zhu DY, Lau L, Liu SH, Wei JS, Lu Y (2004) Activation of cAMP response element binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. USA 101: 9453-9457

9. Wang J, Liu S, Fu Y, Wang JH, Lu Y. (2003) Cdk5 activation induces CA1 pyramidal cell death by direct phosphorylating NMDA receptors. Nature Neuroscience 6: 1039-1047

10. Lu, Y., Roder, J., Davidow, J., and Salter, M.W. (1998). Src activation in the induction of long-term potentiation in CA1 hippocampal neurons. Science 279, 1363-1967.

Awards and Honors

1. 2000-2006 New Investigator Award by Canada Institute for Health Research
2. 2000-2005 Research Scholar by Alberta Heritage Foundation for Medical Research
3. 1999-2000 Senior Research Fellow by Canada Institute for Health Research
4. 1997-1999 Siminovitch-Salter Award by University of Toronto
5. 1997-1999 Joe A. Connolly Memorial Award for Cell Biology by University of Toronto
6. 1996-1999 Tenable Merit Scholarship by University of Toronto
7. 1996-1999. Doctoral Research Award by Medical Research Council (MRC) of Canada.

Courses Taught