ZHANG BIN-Tongji Medical College

ZHANG BIN

Author： Source： Date：October 4, 2017 Cilk Times：[]

Job title: Professor

Phone: 86-27-83692622

Email: binzhang@hust.edu.cn

Academic Areas: Neurobiology, Neurophysiology

Research Interests: The molecular mechanisms of synapse formation using the neuromuscular junction as model

Our group focus on two major areas:

Understanding the molecular mechanisms of synapse formation. Combining the molecular, cellular and neuro-electrophysiological approaches, we will determine the key signaling pathways in the NMJ formation and development.
Understanding the pathogenesis mechanisms of the NMJ related neurologic diseases. We will explore the underlining mechanisms of these diseases, and further develop novel diagnostic methods and treatments.

Academic Degrees

Ph. D. in Biochemistry and Molecular Biology, 2002, Peking Union Medical College

M. S. in Virology and Molecular Biology, 1999, Wuhan University

B. S. in Virology and Molecular Biology, 1996, Wuhan University

Professional Experience

Professor (2013-present): Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology；

Assistant Research Scientist (2009-2013): Medical College of Georgia, Augusta University

Selected Publications

1. Lei Li*, Yu Cao*, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chengyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, Lin Mei. Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron. 92(5):1007-1019, 2016. *, equal contributing authors.

2. Chao Shi, Xuan Huang, Bin Zhang, Dan Zhu, Huqiao Luo, Quqin Lu, Wen-Cheng Xiong, Lin Mei, Shiwen Luo. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS One. 10(9):e0138936, 2015.

3. Robert P. Lisak, Bin Zhang, Chengyong Shen, Lin Mei. Neuromuscular junction as Achilles' heel: yet another autoantibody? Neurology. 84(2):214-5, 2015.

4. Arnab Barik, Bin Zhang, Gurkirpal S. Sohal, Wen-Cheng Xiong, Lin Mei. Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. Dev Neurobiol. 74(8):828-38, 2014

5. Bin Zhang*, Chengyong Shen*, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P. Lisak, Lin Mei. Autoantibodies to agrin in myasthenia gravis patients. PLoS One. 9(3):e91816, 2014. *, equal contributing authors.

6. Chengyong Shen^※, Yisheng Lu^※,Bin Zhang^※, Dwight Figueiredo, Jonathan Bean, Jiung Jung, Haitao Wu, Arnab Barik, Dong-Min Yin, Wen-Cheng Xiong and Lin Mei. Immunization with LRP4 induces myasthenia gravis in mice. J Clin Invest. 123(12):5190-202, 2013. ^※,equal contributing authors.

7. Bin Zhang, Chuan Liang, Ryan Bates, Yiming Yin, Wen-Cheng Xiong, Lin Mei. Wnt proteins regulate acetylcholine receptor clustering in muscle cells. Mol Brain. 5:7, 2012.

8. Yinong Zong, Bin Zhang, Shenyan Gu, Kwangkook Lee, Jie Zhou, Guorui Yao, Dwight Figueiredo, Kay Perry, Lin Mei, Rongsheng Jin. Structural basis of agrin-LRP4-MuSK signaling. Genes Dev. 26(3): 247-58, 2012

9. Bin Zhang, John S. Tzartos, Maria Belimezi, Samia Ragheb, Beverly Bealmear, Richard A. Lewis, Wen-Cheng Xiong, Robert P. Lisak, Socrates J. Tzartos, Lin Mei. Autoantibodies to Lipoprotein-Related Protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol. 69(4):445-51, 2012. Epub 2011 Dec 12.

10. Fei Xiong, Sergey Leonov, Amber Cyan Howard, Shan Xiong, Bin Zhang, Lin Mei, Paul McNeil, Sylvia Simon, Wen-Cheng Xiong. Receptor for Advanced Glycation End Products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-Catenin-dependent Manner. J. Biol. Chem. 286: 35061-70, 2011.

11. Shi-wen Luo, Chun Zhang, Bin Zhang, C-H. Kim, Y-Z. Qiu, Lin Mei, and Wen-Cheng Xiong. Regulation of heterochromatin remodeling and myogenin expression by FAK interaction with MBD2. EMBO J, 28(17): 2568-82, 2009.

12. Bin Zhang, Wen-Cheng Xiong, Lin Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev Cell. 16(3):325-7, 2009.

13. Bin Zhang, Shi-wen Luo, Qiang Wang, Tatsuo Suzuki, Wen-Cheng Xiong, Lin Mei. LRP4 serves as a coreceptor of agrin. Neuron. 60(2):285-97, 2008 .

14. Shi-wen Luo, Bin Zhang, Xian-ping Dong, Yanmei Tao, Annie Ting ,Zheng Zhou, James Meixiong, Junjie Luo, F.C. Alex Chiu, Wen C. Xiong, Lin Mei. HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron. 60(1):97-110, 2008

15. Xiao-Ming Li*, Xian-Ping Dong*, Shi-Wen Luo, Bin Zhang, Dae-Hoon Lee, Annie K L Ting, Hannah Neiswender, Chang-Hoon Kim, Ezekiel Carpenter-Hyland, Tian-MingGao, Wen-Cheng Xiong, Lin Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nat Neurosci. 11(3):262-8, 2008. *, equal contributing authors.

16. Qiang Wang*, Bin Zhang*, Ye Elaine Wang, Wen-Cheng Xiong, Lin Mei. The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering. Neurosignals. 16(2-3):246-53, 2008. *, equal contributing authors

17. Bin Zhang*, Shi-wen Luo*, Xian-Ping Dong*, Xian Zhang, Chunming Liu, Zhenge Luo, Wen-Cheng Xiong, Lin Mei. β-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-73, 2007. *, equal contributing authors

Courses Taught

510.502 Advances in Physiology (graduate)

510.817 Stem Cell Techniques and Applications (graduate)

1001131 Physiology (undergraduate)

1001043 Functional Experiment I (undergraduate)

1001064 Functional Experiment II (undergraduate)