MU YANGLING-Tongji Medical College

MU YANGLING

Author： Source： Date：October 4, 2017 Cilk Times：[]

Job title: Professor and Chair

Phone: +86 (27) 83692622

Email: ymu@hust.edu.cn

Academic Areas: Neurophysiology, Neurobiology

Research Interests: The essential goal of my lab is to understand how the brain selectively encodes acquired information into long-term memory, with current focus on the hippocampus, a structure critical for spatial and episodic memories.

Selected Publications

Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage FH, Mu Y. Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. Proc Natl Acad Sci U S A 113, E5501-10, 2016.
Mu Y, Zhao C, Toni N, Yao J, Gage FH. Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. Elife4, e07871, 2015.
Mu Y, Zhao C, Gage FH. Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci 31, 4113-23, 2011.
Mu Y, Poo M. Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system. Neuron 50, 115-25, 2006.
Lien CC, Mu Y, Vargas-Caballero M, Poo M. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 9, 372-80, 2006.
Shu S, Zhu H, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu L, Lu Y. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's disease via Activation of DAPK1. J Neurosci 36:10843-52, 2016.
Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. Cell Metab 21, 628-36, 2015.
Yang F, Liu Y, Tu J, Wan J, Zhang J, Wu B, Chen S, Zhou J, Mu Y, Wang L. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF. Nat Commun 5, 5627, 2014.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med 19, 473-80, 2013.
Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A 109, 12556-61, 2012.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482, 216-20, 2012.
Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Moran JV, Gage FH. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A108, 20382-7, 2011.
Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221-5, 2011.
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-39, 2010.
Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O´Shea KS, Moran JV, Gage FH. L1 Retrotransposition in Human Neural Progenitor Cells. Nature 460, 1127-31, 2009.
Marchetto MC, Muotri AR, Mu Y, Smith AM, Ceza GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-57, 2008.