Associate Professor

Phone: 86(27)13667175185

Email: zlhu916@hust.edu.cn

Academic Areas: neuropharmacology, neuroscience

Research Interests: ion channel; glial cells; mental disorder

Academic Degrees

Ph.D in Pharmacology, 2008, Tongji Medical College of Huazhong University of Science & Technology.

M.Sc. in Pharmacology, 2004, Tongji Medical College of Huazhong University of Science & Technology.

B.Sc. in Clinical Medicine, 1999, Tongji Medical University.

Professional Experience

Associate Professor (2010-present), Huazhong University of Science and Technology, Department. of Pharmacology;

Lecturer (2005-2010), Huazhong University of Science and Technology, Department. of Pharmacology;

Assistant Professor (1999-2005) , Huazhong University of Science and Technology, Department. of Pharmacology.

Selected Publications

1. Hui Fu, Peng Fang, Hai-Yun Zhou, Jun Zhou, Xiao-Wei Yu, Ming Ni, Jie-Yan Zheng, You Jin, Jian-Guo Chen, Fang Wang and Zhuang-Li Hu*. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain. Clin Exp Pharmacol Physiol. 2016 Feb; 43(2):193-202.

2. Yun Ling#, Zhuangli Hu#, Qingli Meng, Peng Fang, Haixia Liu. Bimatoprost Increases Mechanosensitivity of Trigeminal Ganglion Neurons Innervating the Inner Walls of Rat Anterior Chambers via Activation of TRPA1. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):567-76.

3. Xiao-Wei Yu#, Zhuang-Li Hu#, Ming Ni, Peng Fang, Pei-Wei Zhang, Qing Shu, Hua Fan, Hai-Yun Zhou, Lan Ni, Ling-Qiang Zhu, Jian-Guo Chen, and Fang Wang. Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia. Glia. 2015 Mar; 63(3):483-96.

4. Qing Shu#, Zhuang-Li Hu#, Chao Huang, Xiao-Wei Yu, Hua Fan, Jing-Wen Yang, Peng Fang, Lan Ni, Jian-Guo Chen, Fang Wang. Orexin-A Promotes Cell Migration in Cultured Rat Astrocytes via Ca2+-Dependent PKCα and ERK1/2 Signals. PLoS One. 2014 Apr 18; 9(4): e95259.

5. Rui-Li Liu, Qiu-Ju Xiong, Qing Shu, Wen-Ning Wu, Jin Cheng, Hui Fu, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu*. Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway. Brain Res. 2012 Aug 21; 1469:164-73.

6. Qiu-Ju Xiong#, Zhuang-Li Hu#, Peng-Fei Wu, Lan Ni, Zhi-Fang Deng, Wen-Ning Wu, Jian-Guo Chen, Fang Wang. Acid-sensing ion channels contribute to the increase in vesicular release from SH-SY5Y cells stimulated by extracellular protons. Am J Physiol Cell Physiol. 2012 Aug; 303(4):C376-84.

7. Zhuang-Li Hu, Chao Huang, Hui Fu, You Jin, Wen-Ning Wu, Qiu-Ju Xiong, Na Xie, Li-Hong Long, Jian-Guo Chen and Fang Wang. PICK1 disruption attenuates both functions of ASICs and regulations of PKC on ASICs. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1355-62.

8. Chao Huang#, Zhuang-Li Hu#, Wen-ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang and Jian-Guo Chen. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. 2010 Sep;58(12):1415-24.

9. Zhuangli Hu, Juan Chen, Qin Wei, and Yong Xia. Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric Oxide Synthase Phosphorylation and Function: co-commitment and interplay of Akt and AMPK. J. Biol. Chem. 2008 Sep 12; 283(37): 25256-25263.

Courses Taught

1001051 Pharmacology (undergraduate)

1412061 Cosmeceuticals for skin protection(undergraduate)

1411342 Proper lifestyle against modern disease & subhealth (undergraduate)

1411892 Rational drug use (undergraduate)

510.515 Ion channel and patch clamp technology (graduate)

510.544 Advanced pharmacology (graduate)

Project

1. Acid-sensing ion channels in heart: new target for cardiac ischemia. National Natural Science Foundation of China, 2010-2012

2. Acid-sensing ion channels: the key regulatory protein for microglia inflammatory response. National Natural Science Foundation of China, 2012-2015

3. The effect and mechanism of Hv1 channel in microglia on cocaine addiction via regulation of oxidative stress. National Natural Science Foundation of China, 2015-2018