Academic Degrees

1. 2002.9-2006.7, Ph.D. of Immunology, Dept. of Immunology, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China,

2. 1993.9-1996.7, Master of Microbiology, Dept. of Microbiology, Tongji Medical College

3. 1986.9-1991.7, M. D., Dept. of Enviromental medicine in Preventive Medicine and Public Health, Tongji Medical College

Professional Experience

1. 2012.4~2013.2 , visiting scholar, in Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 S.10th St. Philadelphia, Pennsylvania 19107，projects involved with: The mechanism underlying the function of DACH1 and EYA1 in the development of prostate cancer invasion and metastasis

2. 2006.7~so far, Associate Professor, Master Tutor, doctoral supervisor

In Dept. of Immunology, Tongji Medical College, Huazhong University of Science and Technology (HUST), projects involved with: Regulation and its molecular mechanisms of cellular response to LPS by p55PIK; the novel cellular signal transduction pathway of tumor cell apoptosis induced by transmembrane TNF-; the biologic function of lipid raft involved in the signaling of cytotoxicity of transmembrane TNF-.

3. 2002.9~2006.7, as a Ph.D. candidate in Dept. of Immunology, Tongji Medical College, Huazhong University of Science and Technology (HUST), projects involved with: Roles of Positive and Reverse Signaling of mTNF-α in Activation Induced cell death (AICD) of Jurkat Cells.

4. 1999.1~2001.9, postdoctoral fellow, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, United States of American, projects involved with: the Vibrio Pathogenicity Island of Epidemic Vibrio cholerae, NIH grant AI45637 to D. K. R. Karaolis.

5. 1993.9~1996.7, as a Master candidate, dual cultured in National Key Lab. of Genetic Engineering in Virology Institute, Chinese Academy of Preventive medicine, projects involved with the anti-tumor study of Interferon.

Selected Publications

1. 
   

2. Zhu X, Sun L, Lan J, Xu L, Zhang M, Luo X, Gong J, Wang G, Yuan X, Hu     J, Wang J*. BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer. Oncotarget. 2016 Jun 14; 7(24):36501-36509. doi:10.18632/oncotarget.9038.

3. 
   

4. Lai S^#, Wang G^#, Cao X, Luo X, Wang G, Xia X, Hu J*, Wang J*，KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors，Oncotarget，2015，7(2)：1367-1379

    3.  Wang G^#, Yang X^#, Jin Y, Deng Y, Luo X, Hu J*, Wang J*，TGF-β Regulates the Proliferation of Lung Adenocarcinoma Cells by Inhibiting PIK3R3 Expression，Molecular Carcinogenesis，2014，54(S1)：E162-E171

    4. Zhang S, Liu T, Liang H, Zhang H, Yan D, Wang N, Jiang X, Feng W, Wang J（co- corresponding author）Li P, Li Z. Lipid Rafts Uncouple Surface Expression of Transmembrane TNF- from Its Cytotoxicity Associated with ICAM-1 Clustering in Raji Cells. Mol Immunol. 2009 Apr; 46(7):1551-60.

  5. Wang J, Hu B, Xu M, Yan Q, Liu S, Zhu X, Sun Z, Reed E, Ding L, Gong J, Li QQ, Hu J. Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa. Int J Mol Med. 2006 Feb; 17(2):309-17.

  6. Wang J, Hu B, Xu M, Yan Q, Liu S, Zhu X, Sun Z, Tao D, Ding L, Reed E, Gong J, Li QQ, Hu J. Therapeutic effectiveness of bacteriophages in the rescue of mice with extended spectrum beta-lactamase-producing Escherichia coli bacteremia. Int J Mol Med. 2006 Feb; 17(2):347-55.

   7. Xin L, Wang J(co-first author), Zhang H, Shi W, Yu M, Li Q, Jiang X, Gong F, Gardner K, Li QQ, Li Z. Dual regulation of solubletumor necrosis factor- induced activation of humanmonocytic cells via modulating transmembrane TNF-a-mediated “reverse signaling”. Int J Mol Med 2006 Nov; 18:885–92.

 8.  Hu J, Liu S, Wang J(co-first author), Luo X, Gao X, Xia X, Feng Y, Tao D, Wang G, Li X, Zhao J, Ding H, Reed E, Li QQ, Gong J. Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. Int J Oncol. 2005 May; 26(5):1321-7.

Courses Taught

Medical Immunology and Clinical Immunology for undergraduate student,

Molecular Immunology for postgraduate student(master candidates),

Advanced Immunology for postgraduate student (Ph.D. candidates),

Medical Immunology for foreign undergraduate student (Complete English Course).

Project

1. TGF-b promote Treg differentiation through p55PIK in an Akt-independent way，National Natural Science Foundation of China (NSFC)，N0.31670891，,2007.1-2020.12

2． Regulation and its molecular mechanisms of cellular response to LPS by p55PIK.

 National Natural Science Foundation of China (NSFC), No.  81072431, 2011.01-2013.12

3. The novel cellular signal transduction pathway of tumor cell apoptosis induced by transmembrane TNF-a，National Natural Science Foundation of China (NSFC), No. 30872294 , 2009.1-2011.12

4.. The biologic function of lipid raft involved in the signaling of cytotoxicity of transmembrane TNF-a，National Natural Science Foundation of China (NSFC), No. 30671908, 2007.1-2009.12