Academic Degrees
PhD in Department of Pharmacology, 2009, Huazhong University of Science and Technology, Wuhan
MS Department of Pharmacology, 2004, Huazhong University of Science and Technology, Wuhan
BS in Clinic Medicine, 2001, Xianning Medical College
Professional Experience
Associate Professor (2012-present), Huazhong University of Science and Technology, Department of Pharmacology
Lecturer (2009-2012), Huazhong University of Science and Technology, Department of Pharmacology
Visiting Researcher (2007-2009), Virginia Commonwealth University, Department of Physiology
Assistant (2004-2009), Huazhong University of Science and Technology, Department of Pharmacology
Selected Publications
(1) Li C, Lu Q, Huang P, Fu T, Li C, Guo L, Xu X*.Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron. Neuropharmacology. 2015 Aug;95:154-67.
（2）Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q, Guo L, Xu X*. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.Behav Brain Res. 2015 Jul 15;288:1-10.
（3） Li C, Huang P, Lu Q, Zhou M, Guo L, Xu X*. KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.Neuroscience. 2014 Nov 7;280:19-30
（4）Li Y#, Xu XL#, Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q*, Wang J.TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther. 2015 Nov;21(11):905-13.
（5）Xu X, Jiang M, Wang Y, Smith T, Baumgarten CM, Wood MA, Tseng GN*. Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model. PLoS One. 2010 Apr 13;5(4):e10140
（6）Xu X, Jiang M, Hsu KL, Zhang M, Tseng GN*.KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains.J Gen Physiol. 2008 Jun;131(6):589-603.
（7）Xu X, Recanatini M, Roberti M, Tseng GN.Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).Mol Pharmacol. 2008 Jun;73(6):1709-21.
(8) Jiang M, Xu X, Wang Y, Toyoda F, Liu XS, Zhang M, Robinson RB, Tseng GN.. Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem. 2009 ;284(24):16452-62.
Awards and Honors
1. The regulation of Kv7 channels on hippocampal remyelination in the mice model of chronic stress-induced depression. The fundamental Research funds for the central universities,HUST, 2016-2018.
2. The effects and the mechnisms of Kv7/M channels in the chronic stress-induced impairments of learning and memory .Natural Science Foundation of Hubei Province, 2014-2015.
3. The modulation of phosphorylated KCNQ2 on the activity-dependent trafficking of Kv7 channles in hippocampal neurons. National Natural Science Foundation of China , 2011-2013.
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