Professional Experience

Associate Professor (2010-present), Huazhong University of Science and Technology, Department of Pharmacology;

Lecture (2003-2010),           Huazhong University of Science and Technology, Department of Pharmacology

Teaching Assistant (1998-2003),   Huazhong University of Science and Technology, Department of Pharmacology

Selected Publications

1. 
   

2. Wang QT^*, Liu YM^*, Fu Q^*, Xu B, Zhang Y, Kim SJ, Tan R, Barbagallo F, West T, Anderson E, Wei W,  Abel ED, and Xiang YK. Inhibiting insulin-mediated β₂AR activation prevents diabetes-associated cardiac dysfunction. Circulation. 2016 Nov 4. pii: CIRCULATIONAHA.116.022281. (*co-first author)

3. 
   

4. Fu Q ^*, Hu YT, Wang QT, Liu YM, Li N, Kim SJ, Chiamvimonvat N, Xiang YK^*. High  fat diet induces PKA and GRK phosphorylation ofβ₂-adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. Journal of Physiology. (Accepted, *co-corresponding author)

5. 
   

6. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts. Diabetes. 2014 Aug;63(8):2676-89.

7. 
   

8. Fu Q*^#, Kim S^#, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK*. A long -lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes. J Biol Chem. 2014 May 23;289(21):14771-14781 (*co-corresponding author, ^#co-first author)

9. 
   

10. Fu Q*, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. Cell Signal. 2015 Mar;27(3):707-15. (* corresponding author)

    6.  Fu Q, Xiang YK. Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor. Prog Mol Biol Transl Sci. 2015;132:151-88.

    7. Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct;23(7):250-6

   8.  Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M, Fu Q*. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. Br J Pharmacol. 2010 160(6):1561-72. (*corresponding author)

   9. Liu P, Xiang JZ, Zhao L, Yang L, Hu BR, Fu Q*. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide. Acta Pharmacol Sin. 2008 29(6):661-9. (*corresponding author)

  10 Li JJ, Tang Q, Li Y, Hu BR, Ming ZY, Fu Q*, Qian JQ, Xiang JZ*. Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 27(8):1078-84. (*corresponding author)

 11. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30;119 (8):931-43

 12. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XH, Chang J. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of proteinkinase A signaling. Circ Res. 2015 Jan 2;116(1):e1-e10.

 13. Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res. 2013 Feb 1;112 (3):498-509.

 14. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S,Xiang YK. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12;288(15):10298-307.

 15. Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. Palmitoylation Regulates Intracellular Trafficking of β(2) Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes. PLos One. 2012; 7(8): e42658

 16. Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. PNAS. 2012 Apr 24;109(17):6578-83

 17. Feng M, Xiang JZ, Ming ZY, Fu Q, Ma R, Zhang QF, Dun YY, Yang L, Liu H. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats. Cardiovasc Res. 2012 Jan 1;93(1):60-8.

Courses Taught

1001051  Pharmacology (undergraduate)

1411892  Rational drug use  (undergraduate)

1412061  Cosmeceutical for skin protection  (undergraduate)

1411342  Proper lifestyle against modern disease & subhealth (undergraduate)

510.533   Cardiovascular pharmacology (graduate)

1001051  Pharmacology (undergraduate)

1411892  Rational drug use  (undergraduate)

1412061  Cosmeceutical for skin protection  (undergraduate)

1411342  Proper lifestyle against modern disease & subhealth (undergraduate)

510.533   Cardiovascular pharmacology (graduate)

Project

1. The effect of PDE4 inhibitor in diabetes cardiac fibrosis. Natural Science Foundation of Hubei Province,  2016.1-2017.12

2. The role of PDE4 induced by insulin in beta2 adrenergic receptor manner in diabetes cardiac dysfunction.  Natural Science Foundation of China,  2015.1-2018.12

3.  Neurohormones compromise the effect of beta adrenergic receptor blockers in heart failure. Joint Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao, Natural Science Foundation of China,  2015.1-2018.12