Academic Degrees

PhD in Pathophysiology, 2012, Tongji Medical College, Huazhong University of Science and Technology, China

MS in Pathophysiology, 2006, Tongji Medical College, Huazhong University of Science and Technology, China

MD, 2001, Tongji Medical College, Huazhong University of Science and Technology, China

Professional Experience

Associate Professor (2013-present), Pathophysiology Department Tongji Medical College, Huazhong University of Science and Technology, China

Post Doctor (2012-2013),  Neuroscience, LSUHSC,LA,USA

Lecturer (2006-2013), Pathophysiology Department Tongji Medical College, Huazhong University of Science and Technology, China

Teaching Assistant (2001-2006), Pathophysiology Department Tongji Medical College, Huazhong University of Science and Technology, China

Selected Publications

1. 
   

2. Yang Y, Wang ZH, Jin S, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L, Wang JZ. Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness– and helplessness–modulated spatial learning and memory. Nat Commun.2016. doi: 10.1038/ncomms11935.

3. 
   

4. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron. 2012; 73:774-88.

5. 
   

6. Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D1, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Sci Rep. 2016; 6:27283.(Co-corresponding author)

7. 
   

8. Yang X, Yang Y, Liu J, Li G, Yang E. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochem Res. 2012; 37: 15-22. (Co-first author)

9. 
   

10. Yang X, Yang Y, Fu Z, Li Y, Feng J, Luo J, Zhang Q, Wang Q, Tian Q. Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by Calyculin A. J Psychopharmacol. 2011; 25: 1118-25. (Co-first author)

11. 
    

12. Yang Y, Yang XF, Wang YP, Tian Q, Wang XC, Li HL, Wang Q, Wang JZ. Inhibition of protein phosphatases induces transport deficits and axonopathy. J Neurochem. 2007; 102:878-86.

13. 
    

14. Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ.Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016;113:E3773-81.

15. 
    

16. Fu ZQ, Yang Y, Song J, Jiang Q, Lin ZC, Wang Q, Zhu LQ, Wang JZ, Tian Q. LiCl Attenuates Thapsigargin-Induced Tau Hyperphosphorylation by Inhibiting GSK-3 beta In Vivo and In Vitro. J Alzheimers Dis. 2010, 21:1107-17.

17. 
    

18. Yang X, Yang Y, Li G, Wang J, Yang ES. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci. 2008, 34:165-71.

19. 
    

20. Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A. 2007; 104: 3591-3596.

Awards and Honors

2010    Second-grade Award of Excellent Academic Papers in Natural Science Research, Government of Wuhan city, Hubei province.

Courses Taught

1001001 Pathophysiology (Undergraduate)

1004231 Pathophysiology (Eight-year Program of Clinical Medicine)

1004232 Pathophysiology (Chinese-German Medicine class)

510.536 Advanced Methods and Technologies in Neuroscience (graduate)

Project

1. 
   

2. The role of astrocyte impaired BLP-vCA1 inputs in AD-like depression and spatial working memory deficit and its prevention mechanism study. Training Program of the Major Research plan of the National Natural Science Foundation of China, 2017-2019.

3. 
   

4. The effect of repeated learning on spatial memory deficits during AD progressing and its mechanism study. Natural Science Foundation of China, 2008-2010.