Academic Degrees

PhD in Department of Pathphysiology, 2008, Tongji Medical College, Huazhong University of Science and Technology

MD in Clinical Medicine, 2002, Yunyang Medical College, P.R.China

Professional Experience

Associate Professor (2012.11-present), Tongji Medical College, Huazhong University of Science and Technology

Lecturer (2008.08-2012.10), Tongji Medical College, Huazhong University of Science and Technology

Selected Publications

1. 
   

2. Zhu L, Zhang J, Zhou J, Lu Y, Huang S, Xiao R, Yu X, Zeng X, Liu B, Liu F, Sun M, Dai M, Hao Q, Li J, Wang T, Li T, Hu Q. Mitochondrial Transplantation Attenuates Hypoxic Pulmonary Hypertension. Oncotarget. 2016 Jul 13. doi: 10.18632/oncotarget.10596. (IF= 6.368)

3. 
   

4. Su Y, Zhu L (co-author), Yu X, Cai L, Lu Y, Zhang J, Li T, Li J, Xia J, Xu F, Hu Q. Mitochondrial transplantation attenuates airway hyperresponsiveness by inhibition of cholinergic hyperactivity. Theranostics. 2016, 6(8): 1244-1260.  (IF= 8.854)

5. 
   

6. Chen F, Zhu L (co-author), Cai L, Zhang J, Zeng X, Li J, Su Y, Hu Q. A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca²⁺ signaling. Biochim Biophys Acta-Mol Cell Res. 2016, 1863(4): 617-629. (IF= 5.128)

7. 
   

8. Zhu L, Song S, Pi Y, Yu Y, She W, Ye H, Su Y, Hu Q. Cumulated Ca²⁺ spike duration underlines Ca²⁺ oscillation frequency-regulated NF-kB transcriptional activity. J Cell Sci. 2011, 124: 2591-2601. (IF= 6.111)

9. 
   

10. Chen T, Zhu L (co-author), Wang T, Ye H, Huang K, and Hu Q. Mitochondria depletion abolishes agonist-induced Ca²⁺ plateau in airway smooth muscle cells: potential role of H₂O₂. Am J Physiol Lung Cell Mol Physiol. 2010, 298: L178-188. (IF=4.043)

11. 
    

12. Zhu L, Luo Y, Chen T, Chen F, Wang T, Hu Q. Ca²⁺ oscillation frequency regulates agonist-stimulated gene expression in vascular endothelial cells. J Cell Sci. 2008, 121: 2511-2518. (IF= 6.111)

13. 
    

14. Zhou J, Zhang J, Lu Y, Huang S, Xiao R, Zeng X, Zhang X, Li J, Wang T, Li T, Zhu L, Hu Q. Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction. Oncotarget. 2016 Apr 21. doi: 10.18632/oncotarget.8893. (IF= 6.368)

15. 
    

16. Li J, Peng X, Zeng X, Liu B, Hao Q, Yu X, Zhu L, Hu Q. Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application. Sci Rep. 2015, 5:15286. (IF=5.578)

17. 
    

18. Peng X, Li J, Yu X, Tan R, Zhu L, Wang J, Wang R, Gu G, Liu Q, Ren L, Wang C, Hu Q. Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model. Thromb Res. 2015, 135(5): 990-999. (IF=2.447)

19. 
    

20. Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K, Hu Q. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. Cardiovasc Res. 2013, 100(1): 19-27. (IF=5.940)

21. 
    

22. Zhang J, Zhou J, Cai L, Lu Y, Wang T, Zhu L, Hu Q. Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. Antioxid Redox Signal. 2012, 17(3): 471-484. (IF= 8.456)

23. 
    

24. Song S, Li J, Zhu L, Cai L, Xu Q, Ling C, Su Y, Hu Q. Irregular Ca²⁺ wscillations regulate transcription via cumulated spike duration and spike amplitude. J Biol Chem. 2012, 287(48): 40246-40255. (IF= 4.773)

25. 
    

26. Jin S, Lu D, Ye S, Ye H, Zhu L, Feng Z, Liu S, Wang D, Hu Q. A simplified probe preparation for ELISA-based NF-κB activity assay. J Biochem Biophys Methods. 2005, 65(1): 20-29. (IF= 1.994)

27. 
    

28. Zhu L, Zhang J, Zhou J, Lu Y, Huang S, Xiao R, Yu X, Zeng X, Liu B, Liu F, Sun M, Dai M, Hao Q, Li J, Wang T, Li T, Hu Q. Mitochondrial Transplantation Attenuates Hypoxic Pulmonary Hypertension. Oncotarget. 2016 Jul 13. doi: 10.18632/oncotarget.10596. (IF= 6.368)

29. 
    

30. Su Y, Zhu L (co-author), Yu X, Cai L, Lu Y, Zhang J, Li T, Li J, Xia J, Xu F, Hu Q. Mitochondrial transplantation attenuates airway hyperresponsiveness by inhibition of cholinergic hyperactivity. Theranostics. 2016, 6(8): 1244-1260.  (IF= 8.854)

31. 
    

32. Chen F, Zhu L (co-author), Cai L, Zhang J, Zeng X, Li J, Su Y, Hu Q. A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca²⁺ signaling. Biochim Biophys Acta-Mol Cell Res. 2016, 1863(4): 617-629. (IF= 5.128)

33. 
    

34. Zhu L, Song S, Pi Y, Yu Y, She W, Ye H, Su Y, Hu Q. Cumulated Ca²⁺ spike duration underlines Ca²⁺ oscillation frequency-regulated NF-kB transcriptional activity. J Cell Sci. 2011, 124: 2591-2601. (IF= 6.111)

35. 
    

36. Chen T, Zhu L (co-author), Wang T, Ye H, Huang K, and Hu Q. Mitochondria depletion abolishes agonist-induced Ca²⁺ plateau in airway smooth muscle cells: potential role of H₂O₂. Am J Physiol Lung Cell Mol Physiol. 2010, 298: L178-188. (IF=4.043)

37. 
    

38. Zhu L, Luo Y, Chen T, Chen F, Wang T, Hu Q. Ca²⁺ oscillation frequency regulates agonist-stimulated gene expression in vascular endothelial cells. J Cell Sci. 2008, 121: 2511-2518. (IF= 6.111)

39. 
    

40. Zhou J, Zhang J, Lu Y, Huang S, Xiao R, Zeng X, Zhang X, Li J, Wang T, Li T, Zhu L, Hu Q. Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction. Oncotarget. 2016 Apr 21. doi: 10.18632/oncotarget.8893. (IF= 6.368)

41. 
    

42. Li J, Peng X, Zeng X, Liu B, Hao Q, Yu X, Zhu L, Hu Q. Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application. Sci Rep. 2015, 5:15286. (IF=5.578)

43. 
    

44. Peng X, Li J, Yu X, Tan R, Zhu L, Wang J, Wang R, Gu G, Liu Q, Ren L, Wang C, Hu Q. Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model. Thromb Res. 2015, 135(5): 990-999. (IF=2.447)

45. 
    

46. Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K, Hu Q. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. Cardiovasc Res. 2013, 100(1): 19-27. (IF=5.940)

47. 
    

48. Zhang J, Zhou J, Cai L, Lu Y, Wang T, Zhu L, Hu Q. Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. Antioxid Redox Signal. 2012, 17(3): 471-484. (IF= 8.456)

49. 
    

50. Song S, Li J, Zhu L, Cai L, Xu Q, Ling C, Su Y, Hu Q. Irregular Ca²⁺ wscillations regulate transcription via cumulated spike duration and spike amplitude. J Biol Chem. 2012, 287(48): 40246-40255. (IF= 4.773)

51. 
    

52. Jin S, Lu D, Ye S, Ye H, Zhu L, Feng Z, Liu S, Wang D, Hu Q. A simplified probe preparation for ELISA-based NF-κB activity assay. J Biochem Biophys Methods. 2005, 65(1): 20-29. (IF= 1.994)

Courses Taught

1001001 Pathophysiology (undergraduate)

1004231 Pathophysiology (eight-year program of Clinical Medicine)

1004232 Pathophysiology (Chinese-German Medicine class)

510.526 Clinical Pathophysiology (postgraduate)

Project

1. 
   

2. The underlying mechanism of VEGF-induced calcium oscillation in vascular calcification, National Natural Science Foundation of China (general project), 2013-2016 (preside)

3. 
   

4. The mechanism of irregular calcium oscillation in oxide stress-induced vascular injury, Natural Science Foundation of China (youth project), 2010-2012 (preside)

5. 
   

6. Diagnosis and therapy of complication of chronic obstructive pulmonary disease, National key research and development program, 2016-2020  (participate)

7. 
   

8. Extracellular calcium-sensing receptor and pulmonary hypertension, Natural Science Foundation of China (major project), 2014-2018 (participate)

9. 
   

10. Mutated-STIM1 and nuclear calcium signaling, Natural Science Foundation of China (general project), 2014-2017 (participate)