Zhang Huafeng

Job title: Associate Professor

Phone: (86)15171508083

Email: huafeng.z@hotmail.com

Academic Areas: Tumor immunology

Research Interests: Tumor immunology and immunotherapy, cell metabolism

Academic Degrees

PhD in Immunology, 2016, Peking Union Medical College, Beijing, P.R. China.

MS in Biochemistry and molecular Biology, 2013, Tongji Medical College of Huazhong University of Science &Technology, Wuhan, P.R. China.

BS in Pharmacology, 2010, Tongji Medical College of Huazhong University of Science &Technology, Wuhan, P.R. China.

Professional Experience

Associate Professor (2020-present), Dept. of Pathology, Huazhong University of Science and Technology.

Postdoctoral Associate (2016-2020), Dept. of Biochemistry and molecular Biology, Tongji Medical College of Huazhong University of Science &Technology, Wuhan, P.R. China.

Selected Publications

1. Zhang H, Ma J, Tang K, Huang B. Beyond energy storage: roles of glycogen metabolism in health and disease. FEBS J. 2020 Nov 29.

2. Zhang H, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

3. Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56.

4. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

5. Dong W, Zhang H, Yin X, Liu Y, Chen D, Liang X, Jin X, Lv J, Ma J, Tang K, Hu Z, Qin X, Huang B. Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity. OncoImmunology. 2017 Jan 19;6(3):e1282589.

6. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang B. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205.

Project

1. Glycogen catabolism regulates the recall response of CD8+ memory T cells. Natural Science Foundation of China, 2021-2024

2. PCK1-1 directed glycogen metabolic program regulates memory CD8+ T cell formation and maintenance, Natural Science Foundation of China, 2018-2020