MA Jingwei

Author: Source: Date:October 4, 2017 Cilk Times:[]

                           

Job title:  Lecturer

Phone: 86(27)15927328119                                

Email: majingwei@hust.edu.cn                                

Academic Areas: Tumor immunology and Tumor biotherapy

Research Interests:  Immunology

Academic Degrees

PhD in Immunology, 2012, Tongji Medical College of Huazhong University of Science &Technology, Wuhan, P.R. China.

MS in Immunology, 2009, Tongji Medical College of Huazhong University of Science &Technology, Wuhan, P.R. China.

BS in Clinical Medicine, 2006, Medical College of Jining

Professional Experience

Lecturer (2016-present), Dept. of Immunology, Huazhong University of Science and Technology.

Postdoctoral Associate (2012-2015), Dept. of Immunology, Institute of Basic Medical Sciences Academy of Chinese Sciences and School of Basic Medicine, Beijing, P.R. China.

Selected Publications

1. Ma J, Zhang Y, Tang K, Yin X, Zhang H, Li Y, Zhang S, Hu Z, Wang N, Yang X and Huang B. Delivery of chemotherapeutic drug by tumour cell-derived microparticles reverses drug resistance of tumour-repopulating cells. Cell Research. 2016, 26(6):713-27

2. Jin X, Ma J (Co-first author), Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2016, 113:93-104

3. Ma J, Cai W, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Shen G, Huang B. Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin αMβ₂ to tumor cells. J Immunol. 2013, 191:3453-61

4. Ma J, Huang C, Yao X, Shi C, Sun L, Yuan L, Lei P, Zhu H, Liu H, Wu X, Ning Q, Zhou C, Shen G. Inhibition of hepatitis B virus and induction of hepatoma cell apoptosis by ASGPR-directed delivery of shRNA. Plos One. 2012, 7(10):e46096

5. Ma J, Sun T, Park S, Shen G and Liu J. The role of hepatitis B virus X protein is related to its differential intracellular localization.  Acta Biochim Biophys Sin. 2011, 43: 583-588

6. Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang B. Human mesenchymal stem cells facilitate floating tumorigenic cell growth via ammonium-glutamine cycle. Stem cell. 2015, 33:2877-84

7. Zhou Y, Wang S, Ma J, Lei Z, Zhu H, Lei P, Yang Z, Huang B, Shen G. HBx-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem. 2010, 285(16): 12159-68

8. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, C Xue, Wan Y, Huang B. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015, 3:196-205

9. Ma R, Ji T, Chen D, Dong W, Zhang H, Yin X, Ma J, Liang X, Zhang Y, Shen G, Qin X, Huang B. Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression. Oncoimmunology. 2016, 5(4):e1118599

10. Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015

11. Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012, 3:1282

12. Zhang B, Jia H, Liu J, Tang K, Huang C, Ma J, Shen GX, Ye D, Huang B. Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J Immunol. 2010, 185(12): 7199-206

13. Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Biophys Res Commun. 2010, 400(3): 432-6

14. Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X, Huang B. Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials. 2016, 89:56-66

Courses Taught

1001111 Medical Immunology (undergraduate)
1001113 Medical Immunology (undergraduate)
1003631 Medical Immunology (undergraduate)
1003632 Medical Immunology (undergraduate)
510.512 Basic Immunology (graduate)
510.534 Molecular Immunology (graduate)
510.523 Experimental Immunology (graduate)

Project

Tumor cells derived microparticles vaccine stimulate dendritic cells via targeting the lysosomes, Natural Science Foundation of China, 2017-2019

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