PEI Lei

Author: Source: Date:October 4, 2017 Cilk Times:[]

                           

Job title: Lecturer

Phone: 86(27)13477061210                                

Email: peilei@hust.edu.cn                                

Academic Areas: Neurobiology

Research Interests: Cellular and molecular mechanisms of Pain, Cell death mechanisms after Cerebral ischemic stroke, Neural Circuits and Central Post Stroke Pain

Academic Degrees

PhD in Neurobiology, 2011, Huazhong University of Science & Technology, Wuhan

MS in Neurobiology, 2007, Huazhong University of Science & Technology, Wuhan

BS in Clinical Medicine, 1998, Xianning University

Professional Experience

Lecturer (2015-present), Huazhong University of Science and Technology, Department of Neurobiology;

Postdoctoral Research Fellow (2004-2006), Huazhong University of Science and Technology

Visiting Scientist (2009-2010), Netherlands Institute for Neuroscience

Selected Publications

1. L. Chen, L. Pei. Effects of drug-contained sera of Naoluo Xintong versus Zuogui pill on the proliferation and differentiation of in vitro cultured neural stem cells.Chinese Journal of Tissue Engineering Research, 2016, 20(32): 4845-4851. (corresponding author).

2. Y. Zhang, S. Ma, Y. Yi and L. Pei.Abnormal Neural Circuits Model in Central Post-stroke Pain. Acta Psychopathol. 2016, 2:3. (corresponding author).

3. L. Pei, S. Wang, H. Jin, L. Bi, N. Wei, H. Yan, X. Yang, C. Yao, M. Xu, S. Shu, Y. Guo, H. Yan, J. Wu, H. Li, P. Pang, T. Tian, Q. Tian, L.Q. Zhu, Y. Shang, Y. Lu. A Novel Mechanism of Spine Damages in stroke via DAPK1 and Tau. Cereb Cortex. 2015 Nov;25(11):4559-71.

4. H. Jin*, L. Pei*, X. Shu*, X. Yang, T. Yan, Y. Wu, N. Wei, H. Yan, S. Wang, C. Yao, D. Liu, Q. Tian, L. Wang, Y. Lu. Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging. Molecular Neurobiology, 2016 Mar;53(2):851-66.(Co-first author)

5. X. Wang*, L. Pei*, H. Yan*, Z. Wang, N. Wei, S. Wang, X. Yang, Q. Tian, and Y. Lu. Intervention of DAPK1-p53 Interaction Exerts the Therapeutic Effects against Stroke. Stroke, 2014 Oct;45(10):3089-91 (Co-first author)

6. L. Pei, Y. Shang, H. Jin, S. Wang, N. Wei, H. Yan, Y. Wu, C. Yao, X. Wang, L.Q. Zhu, and Y. Lu. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. The Journal of Neuroscience, 2014, 34(19):6546–6556.

7. J Liu, D. Feng, Y. Zhang, Y. Shang, Y. Wu, X. Li, L. Pei*.Chloral Hydrate Preconditioning Protects Against Ischemic Stroke via Upregulating Annexin A1. CNS Neurosci Ther. 2015, 21(9):718-26. (corresponding author).

8. L. Wang, D. Feng, H. Yan, Z. Wang, L. Pei*. The Comparative Analysis of P2X1, P2X2, P2X3 AND P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons.PLoS ONE 9(05): e96699, doi:10.1371/journal.pone.0096699 (corresponding author).

9. L. Chen, F. Lv, L. Pei*. Annexin 1: a glucocorticoid-inducible protein that modulates inflammatory pain.European Journal of Pain, 18 (2014) 338–347 (corresponding author).

10.L. Chen, M. Jiang, L. Pei*. Comparison of Three Method s of Drug Delivery in the

Rat Lumbar Spinal Subarachnoid Space. THE ANATOMICAL RECORD 2012, 295:1212–1220 (corresponding author).

11. L. Pei, J. Zhang, F. Zhao, T. Su, H. Wei, J. Tian, M. Li, J. Shi. Annexin 1 exerts anti-nociceptive effects through formyl-peptide-receptor-like 1 in rat dorsal root ganglion after peripheral inflammatory pain. British Journal of Anaesthesia 2011, 107(6): 948-958.

12. L. Pei, C. Lin, J. Dai, G. Yin*. Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion. Neurosci Bull. 2007;23(2):92-100.

13. K. Zhao, R. Wen, X. Wang, L. Pei, Y. Yang, Y. Shang, N. Bazan, L. Zhu, Q. Tian, and Y. Lu. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability.The Journal of Neuroscience, 2013, 33(20): 8861-8865.

14. Y. Yang, X. Shu, D. Liu, Y. Shang, Y. Wu, L. Pei, X. Xu, Q. Tian, K. Qian, Y. Wang, R. S. Petralia, W. Tu, L. Zhu, J. Wang, Y. Lu. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron 2012, 73(4):774-778.

15. E. Bruinstroop, L. Pei, M. T. Ackermans, E. Foppen, A. J. Borgers, J. Kwakkel, A. Alkemade, E. Fliers, A. Kalsbeek. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system, Diabetes 2012, 61(5):1043-1050.

16. A. Alkemade, C. Yi, L. Pei, M. Harakalova, D. F. Swaab, S. E. la Fleur, E. Fliers, A. Kalsbeek. AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in MSH are related to type 2 diabetes, The Journal of Clinical Endocrinology & Metabolism 2012, 97(6):E925-33.

Courses Taught

510.508 Basis of Neurobiology (graduate)

510.510The advanced features of the nervous system (graduate)

510.525Lectures of neuroscience forefront (graduate)

100433Central nervous system and sensory organs (undergraduate)

Project

1. Cortex-thalamic circuit injury mediates central post stroke pain by Death Associated Protein Kinase 1 signaling, Natural Science Foundation of China, 2015-2019

2.The mechanisms study of Annexin1’s anti-nociceptive effects through regulating the sensitivity of transient receptor potential vallinoid receptor 1. Natural Science Foundation of China, 2012-2015

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