Academic Degrees

PhD in Pathophysiology, 2011, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

BS in Pharmacy,2006, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Professional Experience

Lecturer (2012-present), Tongji Medical College, Huazhong University of Science and Technology, Department of Medical Genetics

Postdoc. (2012-2013), Neuroscience Center, Health Science Center, Louisiana State University

Selected Publications

1. Wei N, Zhu LQ, Liu D. ATF4: a Novel Potential Therapeutic Target for Alzheimer's Disease. MolNeurobiol. 2015 Dec;52(3):1765-70.

2. Xiong YS^#, Liu FF^#, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ*, Zhu LQ*. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.Aging Cell. 2015 Oct;14(5):867-77.

3. Liu D, Wei N, Man HY, Lu Y*, Zhu LQ*, Wang JZ*. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ. 2015 Apr;22(4):583-96.

4. Chen Y^#, Wang B^#, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci. 2014 Feb 12;34(7):2464-70.

5. Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D*, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014 Jan;76Pt A:80-7.

6. Tang H^#, Shen N^#, Jin H^#, Liu D*, Miao X*, Zhu LQ*. GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis. MolNeurobiol. 2013 Dec;48(3):404-11.

7. Tan L, Wang X, Ni ZF, Zhu X, Wu W, Zhu LQ, Liu D. A Systematic Analysis of Genomic Changes in Tg2576 Mice.MolNeurobiol. 2013 Jun;47(3):883-91.

8. Wang X^#, Wang ZH^#, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway. MolNeurobiol. 2013 Feb;47(1):373-81.

9. Peng CX^#, Hu J^#, Liu D, Hong XP, Wu YY, Zhu LQ*, Wang JZ*. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging. 2013 Jun;34(6):1555-63.

10. Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ*, Zhu LQ*. Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components. J Alzheimers Dis. 2013;37(3):515-27.

11. Wang SH^#, Liao XM^#, Liu D, Hu J, Yin YY, Wang JZ*, Zhu LQ*. NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012 Nov;63(6):1085-92.

12. Yang Y^#, Shu X^#, Liu D^#, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation.Neuron. 2012 Feb 23;73(4):774-88.

13. Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN. 2010 Sep;46(8):702-7.

14. Zhu LQ^#, Liu D^#, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010 Mar 10;30(10):3624-33.

15. Zhu LQ^#, Zheng HY^#, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010 Mar 10;30(10):3839-48.

16. Zhu LQ^#, Wang SH^#, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007 Nov 7;27(45):12211-20.

Courses Taught

1001122Medical Genetics (undergraduate)

1001121 Medical Genetics (graduate)

510.543Advances in Medical Genetics (graduate)

510.805Advanced Medical Genetics (Ph.D)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease(Ph.D)

Project

1.Development of a polyhedral structure high performance molecular imaging instrument for brain science study and clinical diagnosis.Natural Science Foundation of China, 2017-2021

2. Role of GSK-3 in dendritic spine plasticity and underlying mechanisms.Natural Science Foundation of China, 2013-2015

3. Role of melatonin receptor 2 in synaptic plasticity and the underlying mechanism.New Investigator Initiate Grant of Huazhong University of Science and Technology, 2015-2016

4. Role of GSK-3 in AD-like synaptic disorder and the underlying mechanism. New Investigator Initiate Grant of Huazhong University of Science and Technology, 2012-2013