Position: Professor in School of Pharmacy, Tongji Medical College
Phone: 15607185566
Email: wkpzcq@163.com
Research Interest:
Extraction, isolation and structure identification of natural polysaccharides
Pharmacological activity and relative mechanism of natural polysaccharides
Pharmacokinetics of natural polysaccharides
Specific targeting of natural polysaccharides and new drug formulations
Academic Degrees:
PhD in Tongji Medical College of Pharmacy, 2007, Wuhan, China.
Professional Experiences:
Professor (2010-present): Department of Pharmacy, HUST
Associate Professor (2002-2010): Department of Pharmacy, HUST
Lecture (1997-2002): Department of Pharmacy, HUST
Selected Publications:
1. Yu Zhang, Zheng Cui, Hao Mei, Jingya Xu, Tao Zhou, Fang Cheng, Kaiping Wang*: Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer. Carbohydrate Polymers 219 (2019): 143-154
2.Yu Zhang, Zihao He, Xiaocui Liu, Zehong Chen, Jinlu Sun,Zhijing Wu, Xiawen Yang, Xinting Chen, Zhuohong Tang*, Kaiping Wang*: Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition. Journal of Functional Foods 54 (2019): 361-370
3. Kaiping Wang, Jun Wu, Jingya Xu, Saisai Gu, Qiang Li, Peng Cao, Mingming Li, Yu Zhang, and Fang Zeng*: Correction of Anemia in Chronic Kidney Disease With Angelica sinensis Polysaccharide via Restoring EPO Production and Improving Iron Availability. Front Pharmacol. 2018; 9: 803.
4. Yu Zhang, Ziming Zheng, Xiawen Yang, Xianglin Pan, Lianglan Yin, Xiao Huang, Qiang Li, Yamin Shu, Qilin Zhang, Kaiping Wang*: A sensitive and rapid radiolabelling method for the in vivo pharmacokinetic study of lentinan. Food Funct., 2018, 9, 3114-3125
5. Weiyong Li, Jinglin Wang, Huiping Hu, Qiang Li, Ying Liu, Kaiping Wang*: Functional polysaccharide Lentinan suppresses human breast cancer growth via inducing autophagy and caspase-7-mediated apoptosis. Journal of Functional Foods. June 2018, 75–85
6. Peng Cao, Jinlu Sun, Mitchell A. Sullivan, Xiao Huang, Hanxiang Wang, Yu Zhang, Na Wang*, Kaiping Wang*: Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules .2018 May;111:1133-1139
7. Kaiping Wang, Hanxiang Wang, Yage Liu, Weizhi Shui, Junfeng Wang, Peng Cao, Hongjing Wang, Ruxu You*, Yu Zhang*: Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism. Journal of Functional Foods. January 2018, Pages 261-271
8. Yu Zhang, Tao Zhou, Li Luo, Zheng Cui, Na Wang, Yamin Shu, Kaiping Wang*: Pharmacokinetics, biodistribution and receptor mediated endocytosis of a natural Angelica sinensis polysaccharide. Artificial Cells, Nanomedicine, and Biotechnology.2017: 1-10.
9. Kaiping Wang, Fang Cheng, Xianglin Pan, Tao Zhou, Xiqiu Liu, Ziming Zheng, Li Luo*, Yu Zhang*: Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo. Drug Delivery. 2017 Nov;24(1):1360-1371.
10.Kaiping Wang, Jun Wu, Fang Cheng, Xiao Huang, Fang Zeng, Yu Zhang*: Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation, Oxidative Medicine and Cellular Longevit, Volume 2017,13 pages.
11. Xiao Huang, Jun Wu, Qiang Li, Saisai Gu, Zehong Chen, Kaiping Wang*: Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression. RSC Adv.2017,7,50378–50388
12 Jinglin Wang, Weiyong Li, Xiao Huang, Ying Liu, Qiang Li, Ziming Zheng, Kaiping Wang*: A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice, oncotarget. 2017 Jan 3; 8(1): 610–623
13. Kaiping Wang, Zhuohong Tang, Ziming Zheng, Peng Cao, Weizhi Shui, Qiang Li and Yu Zhang*: Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocininduced type 2 diabetic BALB/c mice, Food &Function. 2016,7, 4889-4897
14. Kaiping Wang, Peng Cao, Hanxiang Wang, Zhuohong Tang, Na Wang, Jinglin Wang & Yu Zhang*: Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice, Sci. Rep. 2016,6:26229
15. Yu Zhang, Qiang Li, Junfeng Wang, Fang Cheng, Xiao Huang, Yao Cheng, Kaiping Wang*: Polysaccharide from Lentinus edodes combined with oxaliplatin possesses the synergy and attenuation effect in hepatocellular carcinoma, cancer letters. 2016,377:117-125
16. Yu Zhang, Tao Zhou, Hongjing Wang, Zheng Cui, Fang Cheng, Kai-ping Wang*: Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydrate Polymers. 2016,147:401-408
17. Yao Cheng, Jiali Zhou, Qiang Li, Ying Liu, Kaiping Wang*, Yu Zhang*: The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice. Food & Function. 2016,7:1033-1039
18. Kaiping Wang, Zhizhen Song, Hongjing Wang, Qiang Li, Zheng Cui, Yu Zhang*: Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice. International Immunopharmacology. 2016,31:140-148
19. Yu Zhang, Qiang Li, Yamin Shu, Hongjing Wang, Ziming Zheng, Jinglin Wang, Kaiping Wang*: Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway. Journal of functional foods. 2015,15:151-159.
20. Kaiping Wang, Peng Cao, Wezhi Shui, Qiuxiang Yang, Zhuohong Tang, Yu Zhang*: Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors. Food & Function. 2015,6:902-909.
21. Yu Zhang, Yao Cheng, Na Wang, Qilin Zhang, Kaiping Wang*: The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia. Food & Function,2014,5:1381-1388.
22. Kaiping Wang, Jun Wang, Qiang Li, Qilin Zhang, Ruxu You, Yao Cheng, Li Luo, Yu Zhang*: Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus Edodes. Food Research International, 2014,62:223-232.
23. Ruxu You, Jinyu Liu, Shijun Li, Liu Wang, Kaiping Wang*, Yu Zhang*: Alkali-Soluble Polysaccharide, Isolated from Lentinus edodes, Induces Apoptosis and G2/M Cell Cycle Arrest in H22 Cells Through Microtubule Depolymerization. Phytotherapy Research,2014,12:1837-1845
Awards and Honors:
2002 Second prize of excellent teaching quality of Huazhong university of science and technology
2006 The first top ten charm teachers of Huazhong university of science and technology
2006 "Three educations" award of Huazhong university of science and technology
2006 Outstanding young teacher of Huazhong university of science and technology
2008 Excellent female faculty and staff of Huazhong university of science and technology
2010 Second prize of science and technology progress of Hubei province (the first person in charge)
2011 Outstanding foreign science and technology workers of Huazhong university of science and technology
2013 Advanced female faculty and staff in Hubei education system
2014 Excellent communist party member of Huazhong university of science and technology
2015 "Intimate mentor" of Huazhong university of science and technology
Courses Taught: Physical Chemistry
Centers/Programs:
1. Molecular mechanism of Angelica Sinensis Polysaccharide as an inhibitor of hepcidin involved in iron metabolism (NSFC 81274151,2013-2016).
2. Molecular mechanism of Angelica Sinensis Polysaccharide specific liver targeting (NSFC 81073133, 2010-2013).
3. Molecular mechanism of Angelica Sinensis Polysaccharide inhibiting the expression of hepcidin (NSFC 30973910, 2009-2010).
4. Study on the structure-antitumor activity relationship of Lentinan and its molecular mechanism on inducing apoptosis of tumor cells (NSFC 81373300, 2014-2017).
5. Study on the extraction technology of Chinese herbal compound polysaccharides, the hypoglycemic and hypolipidemic effects and the key technology of new dosage forms (Technology Innovation of Hubei Province 2016ACA147, 2016-2018)
6. Study on the technology of the green extraction method, structural identification and new formulations on medicinal plant polysaccharides (Science and Technology Support Project in Hubei Province 2014BKB088, 2014-2015)
7. Study on molecular mechanism of Angelica Sinensis Polysaccharide regulating glycolipid metabolism (Science and Technology Project of Wuhan 2016060101010059, 2016-2018).
8. Molecular mechanism of Lentinan non-immune pathways on antitumor activity (Science and Technology Project of Wuhan 0216514063, 2013-2014)
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