DU Zhifeng

Author: Source: Date:September 4, 2019 Cilk Times:[]

Position: Associate Professor in School of Pharmacy, Tongji Medical College

Email: duzhifeng@hust.edu.cn

Academic areas: Pharmaceutic analysis

General Introduction:

I am interested in the application of proteomics and metabolomics for mechanism study of disease and therapy.

Academic Degrees

2009. 7 B.S. (Pharmacy) Wuhan University, Wuhan, Hubei province, PR China

2014. 7 Ph.D. (Analytical Chemistry) Institute of Chemistry, Chinese Academy of Sciences. Beijing, PR China

Professional Experiences

2014.9-2016.12 Postdoc, Virginia Commonwealth University, Richmond, VA state, USA

Selected Publications

1. Du, Z.; Luo, Q.; Yang, L.; Bing, T.; Li, X.; Guo, W.; Wu, K.; Zhao, Y.; Xiong, S.; Shangguan, D.; Wang, F.*, Mass spectrometric proteomics reveals that nuclear protein positive cofactor PC4 selectively binds to cross-linked DNA by a trans-platinum anticancer complex. J Am Chem Soc 2014, 136 (8), 2948-2951.

2. Du, Z.; de Paiva, R. E. F.; Nelson, K.; Farrell, N. P.*, Diversity in Gold Finger Structure Elucidated by Traveling-Wave Ion Mobility Mass Spectrometry. Angewandte Chemie 2017, 129 (16), 4535-4538.

3. Du, Z.; de Paiva, R. E. F.; Qu, Y.; Farrell, N.*, Tuning the reactivity of Sp1 zinc fingers with platinum complexes. Dalton Transactions 2016, 45 (21), 8712-8716.

4. Wang, Y.; Du, Z.*; Zheng, W.; Wu, K.; Xu, D.; Luo, Q.; Zhao, Y.; Han, J.; Liu, Y.; Wang, F.*, Deciphering of interactions between platinated DNA and HMGB1 by hydrogen/deuterium exchange mass spectrometry. Dalton Trans 2017, 46 (19), 6187-6195.

5. Jia S, Wang R, Wu K, Jiang H, Du Z*. Elucidation of the Mechanism of Action for Metal Based Anticancer Drugs by Mass Spectrometry-Based Quantitative Proteomics. Molecules. 2019;24(3):581.

6. Li A#, Du Z#, Liao M, Feng Y, Ruan H*, Jiang H.* Discovery and characterisation of lycorine-type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC-QTOF-MS. Phytochemical Analysis. 2019;30(3):268-277.

7. Li, S.; Jin, S.; Song, C.; Jia, S.; Zhang, Y.; Feng, Y.; Du, Z.*; Jiang, H.*, The strategy for establishment of the multiple reaction monitoring based characteristic chemical profile of triterpenes in Alismatis rhizoma using two combined tandem mass spectrometers. Journal of Chromatography A 2017, 1524, 121-134.

8. Yan, Y.#; Du, Z.#; Chen, C.; Li, J.; Xiong, X.; Zhang, Y.*; Jiang, H.*, Lysophospholipid profiles of apolipoprotein E-deficient mice reveal potential lipid biomarkers associated with atherosclerosis progression using validated UPLC-QTRAP-MS/MS-based lipidomics approach. Journal of Pharmaceutical and Biomedical Analysis 2019, 171, 148-157.

Courses Taught: Pharmaceutic analysis, analytical chemistry, advanced pharmaceutic analysis technique


HUST initiation funding

Company program from Jiuzhoutong

Address:  Hangkong Road 13, Wuhan, China
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Tongji Medical College Huazhong University of Science and Technology