Associate Professor

Phone: 027-83692745

Email: 183446033@qq.com

Academic Areas:Biocatalytic synthesis of carbohydrates and glycoconjugates

Research Interests:Focus on the enzyme/cell-mediated synthesis of functional oligosaccharides, glycosylation of natural products, and development of carbohydrate-based anti-infective or cancer-targeted drugs.

Academic Degrees

1.Ph.D. Microbiology in State Key Lab of Microbial Technology, Shandong University, Jinan, China, 2007;

2.B.S. Biology in School of Biology, Hubei Nomal University, Huangshi, China, 2002

Professional Experience

1. Associate Professor (2016.12- present): School of Pharmaceutical Science, Tongji Medical College, HUST, China;

2. Associate Professor (2010.12-2016.11): National Glycoengineering Research Center, Shandong University, China;

3. Visiting Scholar (2013.7-2014.9): Chemistry of Wayne State University, USA;

4. Postdoctor (2007.10-2009.12): School of Pharmaceutical Science, Shandong University, China;

5. Lecturer (2007.7-2010.11): National Glycoengineering Research Center, Shandong University, China.

Selected Publications

1. 1.Xiaodi Chen, Li Xu, Lan Jin, Bin Sun,  Guofeng Gu, Lili Lu^*, Min Xiao^*. Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652.

2. 2.Wei Gong, Li Xu, Guofeng Gu, Lili Lu^*, Min Xiao^*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis.  Appl Microbiol Biotechnol. 2016, 100(15):6693-6702.

3. 3.Lijuan Xu, Tingting Qi, Li Xu, Lili Lu^*, Min Xiao^*. Recent progress in the enzymatic glycosylation      of phenolic compounds. J Carbohyd Chem. 2016,  35(1):1-23.

4. 4.Jie Zhang ^#, Lili Lu ^#, Li Lu, Yang Zhao, Liping Kang, Xu Pang,      Jingyuan Liu, Tengchuan Jiang, Min Xiao^*, Baiping Ma^*. Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3.  Glycoconj J. 2016, 33(1):53-62.

5. 5.Lili Lu^#, Jian Gao^#, Zhongwu Guo^*. Labeling cell surface GPIs and GPI-anchored proteins through metabolic engineering with artificial inositol derivatives. Angew Chem Int Ed. 2015,      54(33): 9679-9682.

6. 6.Lili Lu^#, Qian Liu^#, Lan Jan, Zhenghao Yin, Li Xu, Min Xiao^*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One.  2015, 10(10):e0140531.

7. 7.Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao^*. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3. PLoS One. 2015, 10(3):e0121445.

8. 8.Lili Zhang^#, Lili Lu^# Shuquan Fan^#, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao^*. One-step synthesis of α-Gal epitope and      globotriose derivatives by an engineered α-galactosidase, RSC      Adv. 2015, 5, 22361-22364.

9. 9.Lili Lu, Feng Fu, Renfei Zhao, Lan Jin,      Chunjuan He, Min Xiao^*. A recombinant levansucrase from Bacillus licheniformis 8-37-0-1  catalyzes versatile transfructosylation reactions.      Process Biochem. 2014, 49: 1503-1510.

10. 10.Lili Lu, Jian Wu, Deyong Song, Han      Zhao, Yuchuan Guo, Guofeng Gu, Nan Jin, Min Xiao^*. Purification of fructooligosaccharides by immobilized yeast cells and identification of a novel glycoside formed      during the process. Bioresour Technol. 2013, 132:      365-369.

11. 11.Lili Lu, Shuze Xu, Renfei Zhao, Dayu      Zhang, Zhengyi Li, Yumei Li, Min Xiao^*. Synthesis of galactooligosaccharides by CBD fusion β-galactosidase immobilized on cellulose.      Bioresource Technol. 2012, 116:327-33.

12. 12.Lili Lu, Shuze Xu, Lan Jin, Dayu Zhang, Yumei Li, Min Xiao^*. Synthesis of galactosyl sucralose by β-galactosidase from Lactobacillus bulgaricus L3. Food Chem. 2012, 134(1):      269-275.

13. 13.Qian Liu^#, Lili Lu^#, Min Xiao^*. Cell surface engineering of  α-L-rhamnosidase for naringin hydrolysis. Bioresource Technol. 2012, 123: 144–149.

14. 14.Lili Lu^#, Guofeng Gu^#, Min Xiao^*, Fengshan Wang. Separation and structure analysis of trisaccharide isomers produced from lactose by Lactobacillus bulgaricus L3 β-galactosidase. Food Chem.      2010, 121(4):1283-1288.

15. 15.Lili Lu, Xiaodong Xu, Min Xiao^*, Fengshan Wang. Synthesis of novel  galactose-containing chemicals by β-galactosidase from Enterobacter cloacae B5. Bioresource Technol. 2010, 101(17):      6868-6872.

16. 16.Yumei Li^#, Lili Lu^#, Hongmei Wang, Xiaodong Xu, Min Xiao^*. Cell-surface engineering of a β-galactosidase for galactooligosaccharide synthesis. Appl Environ Microbiol. 2009, 75(18): 5938-5942.

17. 17.Lili Lu, Min xiao^*, Zhengyi Li, Yumei Li, Fengshan wang. A novel transglycosylating β-galactosidase from Enterobacter cloacae B5. Process Biochem. 2009, 44 (2): 232-236.

18. 18.Lili Lu, Min Xiao^*, Han Zhao, Xiaodong Xu, Fengshan Wang.  Pharmacological chaperones: novel therapeutic strategies to rescue defective protein folding and trafficking. Prog Biochem Biophys.      2008, 35(8): 875-885.

19. 19.Lili Lu, Min Xiao^*, Xiaodong Xu, Zhengyi Li, Yumei Li. A  novel β-galactosidase capable of glycosyl transfer from      Enterobacter agglomerans B1. Biochem Biophys Res Commun.      2007, 356 (1): 78-84.

20. 20.Lili Lu, Min Xiao^*, Han Zhao, Peng Wang, Xinmin Qian.  1-Glycosyl fluorides in carbohydrate synthesis by chemoenzymatic methods. Chinese  J Org chem. 2006, 26 (12): 1631-1639.

21. 21.Lili Lu, Min Xiao^*, Han Zhao, Peng Wang, Xinmin Qian.  Glycosynthases: a novel efficient synthetic tool for oligosaccharides. Prog Biochem Biophys. 2006, 33 (4): 310-320.

Awards and Honors

1. Lili Lu, Min Xiao, Yuchuan Guo. A method  for preparation of catechol galactoside. Patent number: ZL 2013 1      0255797.5, 08/05/2015

2. Lili Lu, Min Xiao, Yuchuan Guo. Caffeic acid glycosides and their preparation. Patent number: ZL 2013 1 0257383.6,      06/10/2015

3. Lili Lu, Min Xiao, Yuchuan Guo.  m-Trihydroxybenzene glycosides and their preparation. Patent number: ZL      2013 1 0256401.9, 09/17/2014

4. Lili Lu, Min Xiao, Yuchuan Guo. A method for preparation of resveratrol galactoside. Patent number: ZL 2013 1      0257340.8, 08/27/2014

Awards and Honors

1. Lili Lu, Min Xiao, Yuchuan Guo. A method for preparation of catechol galactoside. Patent number: ZL 2013 1      0255797.5, 08/05/2015

2. Lili Lu, Min Xiao, Yuchuan Guo. Caffeic  acid glycosides and their preparation. Patent number: ZL 2013 1 0257383.6,  06/10/2015

3. Lili Lu, Min Xiao, Yuchuan Guo. m-Trihydroxybenzene glycosides and their preparation. Patent number: ZL   2013 10256401.9, 09/17/2014

4. Lili Lu, Min Xiao, Yuchuan Guo. A method for preparation of resveratrol galactoside. Patent number: ZL 2013 10257340.8, 08/27/2014

Courses Taught

Microbial Detection Technology, Microbe and Human, Glycobiology

Project

1. 2015-2017   Glycosidase-mediated synthesis of anti-infective oligosaccharide drugs against enterohemorrhagic Escherichia coli. Key Development Project of Shandong Province   (2015GSF121004).

2. 2012-2015 Large scale production of      burdock fructooligosaccharide and development of galactosidases. Sub-project of National High Technology Research and Development Program      (863) of China (2012AA021501).

3. 2012-2014 Synthesis of globotriose by  α-galactosidase. Independent Innovation Foundation of Shandong University  (2012TS014).

4. 2011-2013 Broadening acceptor selectivity for transglycosylation by molecular modification of β-galactosidase. National Natural Science Foundation of China (31000035).

5. 2011-2012 Glycosylation of phenolic chemicals by β-galactosidases. Science and Technology Development Project  of Shandong Province (2011GSF12104).

6. 2009-2011 Molecular evolution of glycosidase to broaden the acceptor selectivity for transglycosylation.  Research Fund for the Doctoral Program of Higher Education of China  (200804221016).

7. 2008-2009 Widening the acceptor selectivity for transglycosylation by glycosidase engineering. China Postdoctoral Science Foundation (20080431187).

8. 2008-2009 Structure and bioactivity of  galactooligosaccharide produced by probiotics. Special Funds for Postdoctoral Innovative Projects of Shandong Province (200802025).