SI Luqin

Author: Source: Date:September 6, 2019 Cilk Times:[]

Associate Professor

Phone: 027-83692745


Academic Areas:pharmaceutics, biopharmaceutics and pharmacokinetics

Research Interests:advanced dosage forms, application of biopharmaceutics and pharmacokinetics to study drug absorption, distribution, metabolism and excretion.

Academic Degrees

PhD Pharmacology, 2006, Huazhong Univ Sci Tech, Wuhan, China;


MS Pharmaceutics, 2001, Hangzhou, China;

BA pharmacy, 1998, Tongji medical college, Wuhan, China.

Professional Experience

Associate Professor (2009- present), Department of pharmaceutics, HUST

Visiting scholar (2011-2012), Leslie dan faculty of pharmacy, Univ of Toronto

Lecture (2003-2009), Department of pharmaceutics, HUST

Teaching assistant (2001-2003), Department of pharmaceutics, HUST

Selected Publications

  • Yan Xingjin#, Zhao Shouwei#, Zhu Wenwen,      Rao Jing, Kang Lli, Xu Jiaqiang, Li Dan, Qin Lihui, Qiu Lixia, Li Gao,      Huang Jiangeng, Si Luqin*.LC-MS/MS assay of ropinirole in rat      biological matrices: elimination of lysoglycerophospho-cholines-based      matrix effect.Bioanalysis. 2016;8(17):1823-35.

  • Xue Kewen, Li Gao, Sun Xiao, Hu Ying, Hu      Lei, Huang Jiangeng*, Si Luqin*.Simultaneous quantification of fosinopril      and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS:      Application of formic acid in the stabilization of an ester-containing      drug.J Chromatogr B Analyt Technol Biomed Life      Sci. 2015;990:141-9.

  • Hu Lei, Lv Zhenhua, Li Gao, Xu Xiaolong,      Zhang Chenghao, Cao Peng, Huang Jiangeng*, Si Luqin*.Study      of the in vitro metabolism of TJ0711 using ultra high performance liquid      chromatography with quadrupole time-of-flight and ultra fast liquid      chromatography with quadrupole linear ion trap mass spectrometry.J Sep      Sci. 2015;38(11):1837-49.

  • Guo Weilin, Li Gao, Yang Yanxia, Yang      Conglian, Si Luqin*, Huang Jiangeng*. LC-MS/MS analysis of pramipexole in      mouse plasma and tissues: elimination of lipid matrix effects using weak      cation exchange mode based solid-phase extraction.J Chromatogr B Analyt      Technol Biomed Life Sci. 2015;988:157-65.

  • Yang QJ#, Si Luqin#, Tang Hui, Sveigaard      HH, Chow EC, Pang KS*.PBPK modeling to unravel nonlinear      pharmacokinetics of verapamil to estimate the fractional clearance for      verapamil N-demethylation in the recirculating rat liver preparation.Drug      Metab Dispos. 2015;43(4):631-45.

  • Gang Zhao, Jiangeng Huang, Kewen Xue,      Luqin Si*, Gao Li. Enhanced intestinal absorption of      etoposide by self-microemulsifying drug delivery systems: roles of      P-glycoprotein and cytochrome P450 3A inhibition. Eur J Pharm Sci,      50(3-4):429-39, 2013.

  • Jiangeng Huang, Lei Hu, Li Xu, Minghui      Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitro      enantioselective metabolism of TJ0711 hydrochloride by human liver      microsomes using a novel chiral liquid chromatography-tandem mass      spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci,      891-892:98-101,2012.

  • Minghui Sun, Xuezhen Zhai, Kewen Xue, Lei      Hu, Xiangliang Yang, Gao Li, Luqin Si*. Intestinal absorption and intestinal      lymphatic transport of sirolimus from self-microemulsifying drug delivery      systems assessed using the single-pass intestinal perfusion (SPIP)      technique and a chylomicron flow blocking approach: linear correlation      with oral bioavailabilities in rats. Eur J Pharm Sci, 43(3):132-40,2011.

Courses Taught

Pharmaceutics, Biopharmaceutics & Pharmacokinetics, Clinical Pharmacokinetics, Nano-Pharmaceutics


·1. Effects of excipiects on the function of intestinal PepT1 (NSFC 30901860, 2010-2012).

·2. Intervention of polymeric micelle nanocarriers on the function of liver transporters/CYP450 enzymes and regulation mechanisms (NSFC 81473170 , 2015-2018).

Address:  Hangkong Road 13, Wuhan, China
Tel: +86 87542457(Admission Office)  Tel: +86 83692919(International Cooperation) Office)
Tongji Medical College Huazhong University of Science and Technology