Name:  YUAN Shuiqiao

        Phone:  +8615527507840

        Email:  shuiqiaoyuan@hust.edu.cn

        Job title:  Professor of Reproductive Medicine

Academic Areas

       Reproductive Medicine

Research Interests

       Genetic and epigenetic regulation in germ cell，Mechanism of spermatogenesis and oogeness，Genome editing

Brief introduction

        Broadly, my research field lies in aspects of human genetics and reproductive biology with the keen focus on investigating the genetic architecture of human infertility and the function of microRNAs in germ cells source of fertility. During my Ph.D. and Post-doctoral tenures, I greatly enhanced the understanding of the complex infertility genetic causes and focused on the testis and ovary specific expressed gene datasets in an attempt to dissect the genetic architecture of human infertility. During these years, my primary responsibilities included both the design and implementation of the experiments, as well as daily oversight of laboratory technicians. I worked with both graduate and undergraduate students in the laboratory in an advisory capacity on their projects. I have also been an integral part of the analysis teams for numerous past and ongoing projects. My research field focused on the molecular structure, genetic defect, and related small non-coding RNAs in germ cells. I have an extensive track record in human reproductive biology and have developed an international reputation among peers. In the last 10 years of my research experience, I have published numerous high-impact papers on male and female genetic infertility discoveries and their regulations in the most prestigious scientific journals such as PNAS, EMBO J, Development, Scientific Reports, PLoS One, Biology of Reproduction, and Molecular Reproduction and Development etc.

Academic Degrees

         Ph.D. in Zoology, 2013, China Medical University, Shenyang, China

        Master in Animal genetic and reproduction, 2006, Shenyang Agricultural University, Shenyang, China

Professional Experience

        Professor, 2016-present, Tongji Medical College at Huazhong University of Science and Technology, Wuhan, China

        Post-doc fellow, 2013-2016, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, USA

        Research associate, 2010-2013, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, USA

        Associated director, 2006-2009, Laboratory of Assisted Reproductive Technology Medicine center, Shenyang 204 Hospital, China

Selected Publications

1.  Yanagimachi R, Harumi T, Matsubara H, Yan W, Yuan S, Hirohashi N, Iida T, Yamaha E, Arai K, Matsubara T, Andoh T, Vines C, Cherr GN. Chemical and physical guidance of fish spermatozoa into the egg through the micropyle. Biol Reprod. 2017 Apr 1;96(4):780-799.(IF=3.46)

2.  Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW.MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398.(IF=9.79)

3.  Shuiqiao Yuan, Andrew Schuster, Chong Tang, Tian Yu, Nicole Ortogero, Jianqiang Bao, Huili Zheng, Wei Yan. Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development. Development, 2016, 143(4):635-47. (IF=6.46)

4.   Daniel Oliver, Shuqiao Yuan, Hayden Mcswiggin, Wei Yan. Pervasive genotypic mosaicism in founder mice derived from genome editing through pronuclear injection. PLoS One, 2015, Jun 8;10(6):e0129457. (IF=3.53)

5.  Shuiqiao Yuan, Hayden Mcswiggin, Huili Zheng and Wei Yan. A Testis-specific Gene, Ubqlnl, Is Dispensable for Mouse Embryonic Development and Spermatogenesis. Molecular Reproduction and Development, 2015, Jun;82(6):408-9. (IF=2.68)

6.  Shuiqiao Yuan, Daniel Oliver, Andrew Schuster, Huili Zheng and Wei Yan. Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice. Scientific Reports, 2015, Mar:18; 5:9266. (IF=5.58)

7.  Shuiqiao Yuan, Weibing Qin, Connor R. Riordan, Hayden Mcswiggin, Huili Zheng and Wei Yan. Ubqln3, a testis specific gene, is dispensable for embryonic development and spermatogenesis in mice. Molecular Reproduction and Development, 2015, 82(4):266-7. (IF=2.68).

8.  Shuiqiao Yuan, Clifford J. Stratton, Jianqiang Bao, Huili Zheng,Bhupal P. Bhetwal, Ryuzo Yanagimachi, Wei Yan. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proc Natl Acad Sci U S A, 2015, Feb 3;112(5):E430-9. (IF=9.81)

9.  Shuiqiao Yuan, Chong Tang, Ying Zhang, Jingwen Wu, Jianqiang Bao, Huili Zheng, Chen Xu, Wei Yan. mir--34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice. Biol Open, 2015, Jan 23;4(2):212-23. (IF=2.41)

10.  Jianqiang Bao, Chong Tang, Shuiqiao Yuan, Bo T Porse, Wei Yan. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development, 2015, Jan 15; 142(2):352-62. (IF=6.46)

11.  Shuiqiao Yuan, Nicole Ortogero, Qiuxia Wu, Huili Zheng, Wei Yan. Murine follicular development requires oocyte DICER, but not DROSHA. Biology of Reproduction, 2014 Aug; 91(2):39. (IF=4.1)

12.  Jingwen Wu, Jianqiang Bao*, Minkyung Kim*, Shuiqiao Yuan*, Chong Tang, Huili Zheng, Grant S. Mastick, Chen Xu, Wei Yan.(*equal contribution). Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A, 2014, 111 (28), E2851-E2857. (IF=9.81)

13.  Jianqiang Bao, Shuiqiao Yuan, Ashley Maestas, Bhupal P Bhetwal, Andrew Schuster, Wei Yan. Stk31 is dispensable for embryonic development and spermatogenesis in mice. Molecular Reproduction and Development, 2013, 80(16):786. (IF=2.68)

14.  Shuiqiao Yuan, Huili Zheng, Zhihong Zheng, Wei Yan. Proteomic Analyses Reveal a Role of Cytoplasmic Droplets as an Energy Source during Epididymal Sperm Maturation. PLoS ONE, 2013, 8(10):e77466. (IF=3.53)

15.  Hui Xu*, Shui-Qiao Yuan*, Zhi-Hong Zheng, Wei Yan. (*Co-first author) The Cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis. Asian Journal of Andrology, 2013, 15 (6), 799-805. (IF=2.53)

Awards and Honors

        Larry Ewing Memorial Trainee Travel Fund (LEMTTF) in June of 2015 at 48th Annual Meeting of the Society for the Study of Reproduction.

Grants

1. The role and mechanism of mitofusin 2 on spermatogenesis （NSFC, 31671551）

2. The function of sperm non-coding RNA modification in male infertility (HUST, 2016JCTD119)

In The Media

        Lab website: www.sqyuan-lab.com