Name: ZHOU Liquan

   Phone: 13554302039

   Email: zhouliquan@hust.edu.cn

   Job title: Professor of Reproductive Biology

Research Interests

Transcriptional and Epigenetic Regulation in Mammalian Reproduction

Brief introduction

Dr. Li-quan Zhou studied eukaryotic gene regulation in Peking Union Medical College during his PhD period, using human primary hematopoietic progenitor cells as the model system. After that, Dr. Zhou went to National Institutes of Health and used mouse genetics to study how chromatin structure is reorganized during gametogenesis and early embryogenesis. Dr. Zhou came to Tongji Medical College to establish his own lab, and his major research interest is transcriptional and epigenetic regulation in mammalian reproduction.

Academic Degrees

M.S., Biochemistry & Molecular Biology, 2006, Xi'an Jiaotong University, Xi'an, China;

    Ph.D., Medical Molecular Biology, 2010, Peking Union Medical College, Beijing, China.

Professional Experience

    Postdoctoral Fellow (2010 - 2016); NIDDK, National Institutes of Health (NIH), Bethesda, MD

    Professor (2017 - present); Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Selected Publications

(For full publication list, see: http://orcid.org/0000-0002-9332-9408)

1. Li, Z., Zhang, X., Xie, S., Liu, X., Fei, C., Huang, X., Tang, Y., Zhou, L.Q. (2022) H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis. Nucleic Acids Res. 50(12):6786-800.

2. Tian, Q, Zhou, L.Q. (2022) Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells. Cells. 11(3):548.

3. Wang, X.F., Xie, S.M., Guo, S.M., Su, P., Zhou, L.Q. (2020) Dynamic pattern of histone H3 core acetylation in human early embryos. Cell Cycle. 19:2226-2234.

4. Zhou, L.Q., Canagarajah, B., Zhao, Y.G., Baibakov, B., Maric, D., Dean, J. (2017) BTBD18 licenses piRNA-generating loci through transcription elongation in mice. Dev Cell. 40, 453-466.

5. Zhou, L.Q., Baibakov, B., Canagarajah, B., Xiong, B., and Dean, J. (2017) Genetic mosaics and time-lapse imaging identify functions of H3.3 residues in oocyte-to-embryo transition. Development. 144, 519-528.

6. Zhou, L.Q., Dean, J. (2015) Reprogramming the genome to totipotency in mouse embryos. Trends Cell Biol. 25, 82-91.

7. Wu, J., Zhou, L.Q., Yu, W., Zhao, Z.G., Xie, X.M., Wang, W.T., Xiong, J., Li, M., Xue, Z., Wang, X., Zhang, P., Mao, BB., Hao, D.L., Lv, X., Liu, D.P. (2014). PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Blood. 123, 261-270.

Awards and Honors

2012: Nancy Nossal Fellowship Award, NIH, Bethesda, MD

Centers/Programs

     1. Transcriptional regulation of zygotic genome activation

    2. Epigenetic regulation during maternal-to-embryonic transition

    3. Cell fate decision in mammalian preimplantation embryos

(Updated: Sep 2022)