Name：WANG Fengli 

  PhD, Associate Professor, Master/Doctoral Supervisor

 Research Interests: Biology of Reproduction

 Phone Number: 13121200790

 E-mail: wangfengli@hust.edu.cn

 Contact Address: No. 13 Hangkong Road, Qiaokou District, Wuhan City, Hubei Province, China.

Institute of Reproductive Health, Tongji Medical College

Huazhong University of Science and Technology

Academic experience:

From 2011 to 2015, I studied in Institute of Zoology, Chinese Academy of Sciences as a PhD candidate. During this period, my project mainly focused on epigenetic modifications in neurological diseases such as Huntington’s disease to get insight into the pathogenic mechanisms underlying this disease.

During Sep. 2015 to Oct. 2018, I did research work in the Institute of Zoology, Chinese Academy of Sciences as postdoctoral fellow under the supervision of professor Tang tieshan. My work focused on the abnormal DNA damage repair mechanisms in nervous system, especially explored the function of pathogenic proteins of RTT syndrome and ALS (amyotrophic lateral sclerosis) in DNA damage repair.

Academic achievements:

I have undertaken one project of the China Postdoctoral Fundation and participated in three projects of the National Natural Science Foundation of China. At present, I have published 13 SCI papers, of which 7 papers have been published as the first/co-first authors, mainly on acdemic journals such as Nucleic Acids Research, Human Molecular Genetics, Epigenomics, Cellular Signaling, Molecular Biology Reports and so on.

Research fields:

1. The role of DNA damage repair pathway in gametogenesis

2. Abnormal DNA damage repair response and the occurrence of female reproductive system cancers (ovarian, cervical and endometrial cancers)

3. DNA damage response during reproductive system aging

Awards and Honors:

Second Prize of the Third “Hengyuanxiang Talent” Award, 2014

Chinese Society of Neuroscience-Sanofi Excellent Conference Paper Award, 2013

National scholarship for doctoral students, 2013

"Merit Student" of University of Chinese Academy of Sciences, 2013

Excellent Master's Thesis of Huazhong Agricultural University, 2011

Projects undertaken or participated:

China Postdoctoral Fundation; The Fundamental Research Funds for the Central Universities’, HUST

Participate in 3 projects of the National Natural Science Foundation of China.

Selected publications:

1. Wang F.L., Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS. Genome-wide loss of 5-hmC is a novel genetic feature of Huntington's diseases. Hum Genet 22: 3641-53, 2013. (DOI: 10.1093/hmg/ddt214. IF₂₀₁₃= 6.677)

2. Wang F.L., Fischhaber PL, Guo C, Tang TS. Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics 6:287-97, 2014. (DOI: 10.2217/epi.14.19. IF₂₀₁₃ = 5.215)

3. Gong J., Huang M., Wang F.L., Ma X., Liu H., Tu Y., Xing L., Zhu X., Zheng H., Fang J., Li X., Wang Q., Wang J., Sun Z., Wang X., Wang Y., Guo C. and Tang T.S. "RBM45 s with HDAC1 for binding to FUS in response to DNA damage." Nucleic competencies, 2017. (IF₂₀₁₆ = 10.16, co-first author)

4. Wang F.L., Wang H, Wu H, Qiu H, Zeng C, Sun L, Liu B. TEAD1 controls C2C12 cell proliferation and differentiation and regulates three novel target genes. Cell Signal 25:674-81, 2013. (DOI: 10.1016/j. cellsig. 2012.11.027. IF₂₀₁₃ = 4.471)

5. Wang F.L., Qiu H, Zhang Q, Peng Z, Liu B. Association of two porcine reproductive and respiratory syndrome virus (PRRSV) receptor genes, CD163 and SN with immune traits. Mol Biol Rep 39:3971-6, 2012. (DOI: 10.1007/s 11033-011-1177-4. IF₂₀₁₂ = 2.506)

6. Yang Y., Liu Z., Wang F.L., Temviriyanukul P., Ma X., Tu Y., Lv L., L in Y.F., Huang M., Zhang T., Pei H., Chen B.P., Jansen J.G., de Wind N., Fischhaber P.L., Friedberg E.C., Tang T.S. and Guo C. "FANCD2 and REV1 in the protection of strands in DNA replication" Nucleic Acids Res 43 (17): 8325-8339, 2015. (IF₂₀₁₅ = 9.2, co-first author)

7. Wu H., Wang F.L., Hu S., Yin C., Li X., Zhao S., Wang J., Yan X. MiR-20a and Mi-106 B negatively regulated autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts. Cell Signal 24: 2179-86, 2012. (DOI: 10.1016/j. cell sig. 2012.07.001. IF₂₀₁₂= 4.304, co-first author)

Students who interested in reproductive medicine, reproductive biology and cancer development are welcome to apply for Master's and Doctor's degrees and join our research group.