Job title: Associate professor
Research Interests
Oocyte maturation in vitro; oocyte and embryo quality assessment; cell-free mitochondrial DNA
Academic Areas
Reproductive medicine
Brief introduction
Ling Zhang was born in 1975. She received her B.S. in 1998 from Tongji Medical University and Ph.D in 2009 from Huazhong University of Science and Technology. She is an visiting scholar in UC San Francisco from 2016 to 2017. Since 2015, she became an associate professor, and her research interests are oocyte and embryo quality assessment and oocyte maturation in vitro. She has published over 20 papers in Chinese journals and international journals.
Academic Degrees
Ph. D in Obstetrics & Gynecology, 2009. Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China;
M. S in Obstetrics & Gynecology, 2004. Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China;
B. A in Maternal and Children Health,1998.Tongji Medical University. Wuhan, China.
Professional Experience
Associate professor (2015-current), Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China;
Assistant professor (2006-2014), Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China;
Teaching Assistant (2004-2005), Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China;
Teaching Assistant (1998-2001), Department of maternal and children health, Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China
Selected Publications
Shen Q, Liu Y, Li H, Zhang L*.Effect of mitophagy in oocytes and granulosa cells on oocyte quality. Biol Reprod.2020 Oct 20;ioaa194. doi: 10.1093/biolre/ioaa194.
Liu Y, Shen Q, Li H, Xiang W, Zhang L*. Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse, Reproductive Toxicology. 2020, 98:278-285.
Liu Y, Shen Q, Zhang L*, Xiang W*. Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases. Front Cell Dev Biol. 2020 Sep 17;8:577084. doi: 10.3389/fcell.2020.577084. eCollection 2020.
Shen Q, Chen M, Zhao X, Liu Y, Ren X, Zhang L*.Versican expression level in cumulus cells is associated with human oocyte developmental competence. Syst Biol Reprod Med. 2020 Jun;66(3):176-184.
Liu Y, Shen Q, Zhao X, Zou M, Shao S, Li J, Ren X, Zhang L*.Cell-free mitochondrial DNA in human follicular fluid: a promising bio-marker of blastocyst developmental potential in women undergoing assisted reproductive technology. Reprod Biol Endocrinol. 2019 Jul 10;17(1):54. doi: 10.1186/s12958-019-0495-6.
Belli M#, Zhang L#, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA*, Macchiarelli G*, Rinaudo P*. Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos.Hum Reprod. 2019 Apr 1;34(4):601-611. doi: 10.1093/humrep/dez011.
Rao M#, Zhou F#, Tang L, Zeng Z, Hu S, Wang Y, Ke D, Cheng G, Xia W*, Zhang L*, Zhu C. Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study. Reprod Biomed Online.2019 Jan;38(1):108-117.
Awards and Honors
1. The third prize of the 14th Excellent Academic Paper Award in natural science in Hubei province, 2012.
2. The nomination of Young Faculty “Top ten” Award, Tongji Medical College, Huazhong University of Science and Technology. Wuhan, China, 2011
3. Public welfare prize, Huazhong University of Science and Technology. Wuhan, China, 2008.
4. Excellent Student Award, Tongji Medical University. Wuhan, China,1994-1997.
Courses Taught
Contraception
Centers/Programs
1. The role of cell-free genomic-DNA in embryo culture media in the analysis of embryo genetic information. the Fundamental Research Funds for the Central Universities, China. 2015-2016.
2. “Role of cumulus cells glycolytic activity in the evaluation of oocyte developmental potential.” National Natural Science Foundation of China, 81000274 ,2011-2013.
3. “Role of brain-deried neurotrophic factor in the evaluation of oocyte developmental potential.” Wuhan city youth science and technology fund “the morning program”.China, 2010-2012.
4.“The effect of brain-deried neurotrophic factor on murine immature oocytes.” The School funds of HUST, China,2006-2008.
Chinese
