Name: WANG Xiaoli

         Phone: 027-83692651

Email:  wangxiaoli@hust.edu.cn

Job title：Associate Professor

Academic Areas

Reproductive Medicine

Research Interests

     Genetic and epigenetic regulation in spermatogenesis，Gene editing

Academic Degrees

Ph.D in Medical molecular genetics, Successive master-doctor program, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai

Professional Experience

Lecturer, Master's Supervisor, June 2016 – present

Institute of Reproductive Health, Tongji Medical College of HUST, Wuhan

Visiting scholar, November 2016-December 2016

Cancer Science Institute of Singapore, National University of Singapore (NUS)

Postdoctoral Fellow, October 2012 – May 2016

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University, Wuhan

Selected Publications

1. Xiaoli Wang, Yujiao Wen, Juan Dong, Congcong Cao, Shuiqiao Yuan. Systematic in-depth proteomic analysis of mitochondria-associated endoplasmic reticulum membranes (MAM) in mouse and human testes. Proteomics. 2018 May 21: e1700478. doi: 10.1002/pmic.201700478.

2. Xiaoli Wang，Han Li，Guolong Fu，Yunfu Wang, Shiming Du, Long Yu, Youheng Wei, Shi Chen，Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76, Sci Rep, 2016, 6: 22861.

3. Xiaoli Wang, Youheng Wei, Guolong Fu, Hexige Saiyin, Gang Lin, Zhugang Wang, Shi Chen, Long Yu, Tssk4 is essential for maintaining the structural integrity of sperm flagellum, Mol Hum Reprod, 2015, 21(2): 136-145.

4. Xiao-li Wang, You-heng Wei, Guo-long Fu, Long Yu, Testis specific serine/threonine protein kinase 4 (TSSK4) leads to cell apoptosis relying on its kinase activity, J Huazhong Univ Sci Technolog Med Sci, 2015, 35(2): 235-240.

5. Na Fang, Congcong Cao, Yujiao Wen, Xiaoli Wang, Shuiqiao Yuan, Xunbin Huang. MicroRNA profile comparison of testicular tissues derived from successful and unsuccessful microdissection testicular sperm extraction retrieval in non-obstructive azoospermia patients. Reprod Fertil Dev. 2019 Apr;31(4):671-682. doi: 10.1071/RD17423.

6. Congcong Cao, Yujiao Wen, Juan Dong, Xiaoli Wang, Weibing Qin, Xunbin Huang, Shuiqiao Yuan. Maternally expressed miR-379/miR-544 cluster is dispensable for testicular development and spermatogenesis in mice. Mol Reprod Dev. 2018 Mar;85(3):175-177. DOI:10.1002/mrd.22957.

7. Congcong Cao, Yujiao Wen, Xiaoli Wang, Na Fang, Shuiqiao Yuan, Xunbin Huang. Testicular piRNA profile comparison between successful and unsuccessful micro-TESE retrieval in NOA patients. J Assist Reprod Genet. 2018 May;35(5):801-808.DOI:10.1007/s10815-018-1134-4.

8. Guolong Fu, Youheng Wei, Xiaoli Wang, Long Yu, Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117, Biosci Biotechnol Biochem, 2016, 80(6): 1088-1094.

9. Shuo Liu, Yali Gao, Cheng Zhang, Han Li, Shiyi Pan, Xiaoli Wang, Shiming Du, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen, SAMM50 affects mitochondrial morphology through the association of Drp1 in mammalian cells, FEBS Lett, 2016, 590(9): 1313-1323.

10. Youheng Wei, Xiaoli Wang, Guolong Fu, Long Yu, Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197, Mol Biol Rep, 2013, 40(1): 439-447.

Grants

National Nature Science Foundation, 31801237, The function and molecular mechanism research of RNA binding protein hnRNPH1 in spermatogenesis, 2019/01~2021/12, under research.